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[Butler Brothers, Sketch No. 5199]
No full textThis engine drawing card was created for Butler Brothers, Class 6-28 D. Section N-6 D. Sketch 5199. Copy Spec. B. 3446
Abstract 5199: A novel role for BAP1 in development and tumor suppression
No full textAbstract Uveal melanoma (UM) is the second most common form of melanoma and one of the most deadly types of cancer. Recent discoveries in our laboratory and others have led to a deeper understanding of the driver mutations UM. The initiating mutation that is present in virtually all UM occurs in one of four genes in the Gaq signaling pathway (the “Gaq” mutations) and result in sustained activation of proliferative signals. A second mutation occurs later in one of three genes – BAP1, SF3B1 or EIF1AX (the “BSE” mutations), which determines metastatic risk – BAP1 (high risk), SF3B1 (intermediate risk) or EIF1AX (low risk). Surprisingly, we recently discovered that the Gaq mutation and the subsequent BSE mutation occur very close in molecular time. This work suggests that Gaq mutations may cause epigenetic changes that predispose to BSE mutations. We have shown that BAP1-mutant UMs exhibit a de-differentiation and stem-cell like phenotype, suggesting that BAP1 may normally regulate differentiation programs during embryonic development. Consistent with this possibility, BAP1 loss in mouse is embryonic lethal. To study the role of BAP1 in early vertebrate development, therefore, we chose Xenopus laevis (African clawed frog), a widely used model for studying gene function during development. We found that targeted depletion of the Xenopus BAP1 protein (xBap1) causes a striking developmental phenotype affecting multiple germ layers, and that this phenotype is associated with disruption of super enhancers around differentiation genes that are normally maintained by BAP1. Taken together, these studies suggest that loss of BAP1 promotes tumor progression and metastasis, at least in part, by disrupting tightly controlled differentiation programs that govern cell identity. These findings may nominate new therapeutic targets in BAP1-mutant cancers. Citation Format: Dawn A. Owens, Jeffim N. Kuznetsov, Stefan Kurtenbach, Tristan Agüero, Mary Lou King, J. William Harbour. A novel role for BAP1 in development and tumor suppression [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5199
Collection d’anatomie comparée de l'UMR 5199 PACEA
No full textLa salle François Prat du Laboratoire PACEA (UMR 5199), Université de Bordeaux, contient une riche collection d’anatomie comparée. Cette collection est utilisée par les chercheurs et les étudiants pour déterminer les vestiges animaux provenant des sites archéologiques et paléontologiques. Elle vise à documenter la faune actuelle et passée du territoire national, DOM et TOM inclus. Elle est accessible aux personnes qui en font la demande, dans le cadre d’une action de recherche. La collectio..
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Présentation de Mathilde Lequin: Chargée de recherche CNRS à PACEA (UMR 5199, Université de Bordeaux)
No full textPortrait vidéo de Mathilde Lequin, chargée de recherche CNRS à PACEA (UMR 5199, Université de Bordeaux)Mathilde Lequin est chargée de recherche CNRS à PACEA (UMR 5199, Université de Bordeaux).Philosophe des sciences, elle est spécialiste d’épistémologie de la paléoanthropologie.Ses travaux portent sur les critères d’interprétation des fossiles et sur les critères de définition de l’humain à différents niveaux taxinomiques, à travers un questionnement sur la diversité humaine du passé, au croisement de la philosophie de la biologie et de l’anthropologie philosophique.Elle a notamment publié "Bipédie et origines de l’humanité" (Hermann, 2019)
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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