1,765,723 research outputs found
Pharmacokinetics, pharmacodynamics and safety of CKD-519, a CETP inhibitor, in healthy subjects
No full textChoon Ok Kim,1 Eun Sil Oh,2 Chungam Choi,1 Yeonjoo Kim,3 Sera Lee,4 Semi Kim,4 Min Soo Park1,5 1Department of Clinical Pharmacology, Severance Hospital, Yonsei University College of Medicine, Seoul, 2Department of Pharmaceutical Medicines and Regulatory Science, Colleges of Medicine and Pharmacy, Yonsei University, Incheon, 3Chong Kun Dang Clinical Research, Chong Kun Dang Pharmaceutical Corp., 4Chong Kun Dang Research Institute, Chong Kun Dang Pharmaceutical Corp., 5Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea Abstract: CKD-519 is a selective and potent cholesteryl ester transfer protein (CETP) inhibitor being developed for the treatment of dyslipidemia to raise high-density lipoprotein cholesterol. We investigated the safety, tolerability, pharmacokinetics, and pharmacodynamics of single doses of CKD-519 in healthy adult subjects. A randomized, double-blinded, placebo-controlled, single ascending dose study was performed. Eight healthy subjects were enrolled in each CKD-519 dose group (25, 50, 100, 200, or 400 mg) and randomized to CKD-519 (n=6) or matching placebo (n=2). CKD-519 reached the maximum plasma concentration (Cmax) at 5–6 h post-dose, and had a long terminal half-life ranging between 40–70 h. The area under the plasma concentration–time curve (AUC) and Cmax increased with the dose, however, Cmax and AUC normalized by dose decreased with each incremental dose. CETP activity decreased with dose, and the maximum decrease (63%–83%) was observed at 6–8 h post-dose. A sigmoid Emax model best described the relationship between CKD-519 plasma concentrations and CETP activity with an EC50 of 17.3 ng/mL. Overall, 11 adverse events (AEs) were observed. All AEs were mild or moderate in intensity, and resolved without any complications. There were no clinically significant effects on blood pressure. In conclusion, single doses of CKD-519 up to 400 mg were well tolerated and showed potent inhibition of CETP activity. Keywords: cholesteryl ester transfer protein inhibitor, CKD-519, pharmacokinetics, pharma­codynamic
Resolución UNRN N° 519/2009. Aprobar la re-asignación del personal docente universitario
No full textFil: Universidad Nacional de Río Negro (U). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución UNRN N° 519/2009. Aprobar la re-asignación del personal docente universitariofals
ALVIN 519 A Dive 519 Reel 2
No full textALVIN 519 A Dive 519 Reel 2The runtime for this video is 31m 53s.Alvin dive 519 took place on July 01, 1974 during voyage LU-70. The Chief Scientist was J. Heirtzler in the operating area of Mid-Atlantic Ridge. The purposewas described as 'FAMOUS GEOLOGY' and the sponsor as 'NOAA'.The items in this collection are embargoed in the system in keeping with copyright requirements. However, they are available to users upon request. Please contact the MBLWHOI Library to access the items at [email protected] of this material was supported by a Recordings at Risk grant from the Council on Library and Information Resources (CLIR). The grant program is made possible by funding from The Andrew W. Mellon Foundation. CLIR is an independent, nonprofit organization that forges strategies to enhance research, teaching, and learning environments in collaboration with libraries, cultural institutions, and communities of higher learning. To learn more, visit www.clir.org and follow CLIR on Facebook and Twitter.2200-01-0
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Band 5, 519 (Sammlung Friedlaender)
No full textBAND 5, 519 (SAMMLUNG FRIEDLAENDER)
Band 5, 519 (Sammlung Friedlaender) (Public Domain) (1
Band 3, 519 (Sammlung Friedlaender)
No full textBAND 3, 519 (SAMMLUNG FRIEDLAENDER)
Band 3, 519 (Sammlung Friedlaender) (Public Domain) (1
Band 2, 519 (Sammlung Friedlaender)
No full textBAND 2, 519 (SAMMLUNG FRIEDLAENDER)
Band 2, 519 (Sammlung Friedlaender) (Public Domain) (1
Band 6, 519 (Sammlung Friedlaender)
No full textBAND 6, 519 (SAMMLUNG FRIEDLAENDER)
Band 6, 519 (Sammlung Friedlaender) (Public Domain) (1
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