1,779,740 research outputs found
Trykk 501
No full text501 ; 501a ; 501.1 ; 501.2 ; 501.3 ; 501.4 med tittel: Instrukser for tjenestemenn i elektrotjenesten ; for elektromestere ; for maskinsjef ; for elektrokontrollør i stillverkstjenesten ; for sikkerhetsman
Participant 501 Community Conversations Poetry
No full textIn this poetry submission, Participant 501 shares their experience with job loss, isolation, and medical problems during the COVID-19 pandemic. The participant shares that they are afraid they will fall behind bills and questions whether they will become homeless. They express frustration with the pandemic and how much it has impacted their life.New Jersey Department of Healt
Additional file 1: of Macrophage-derived exosomal microRNA-501-3p promotes progression of pancreatic ductal adenocarcinoma through the TGFBR3-mediated TGF-β signaling pathway
No full textFigure S1. Expression of miR-501-3p and TGFBR3. A. expression of miR-501-3p in pancreatic cancer cell lines after miR-501-3p mimic and miR-501-3p inhibitor treatment detected by RT-qPCR. B. the expression of TGFBR3 in pancreatic cancer cell lines after miR-501-3p mimic and miR-501-3p inhibitor treatment detected by RT-qPCR. (EPS 398 kb
Resolución UNRN N° 501/2009. Otorga equivalencia. No otorgar equivalencia.
No full textFil: Universidad Nacional de Río Negro (U). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución UNRN N° 501/2009. Otorga equivalencia. No otorgar equivalencia.fals
MiR-501-5p alleviates cardiac dysfunction in septic patients through targeting NR4A3 to prevent its binding with Bcl-2
No full textSepsis-induced myocardial dysfunction is a common complication in septic patients. To date, a limited number of biomarkers that could predict cardiomyocyte apoptosis have been explored. In this study, we successfully established a cecal ligation and puncture (CLP)-induced septic model, and it was found that miR-501-5p expression was down-regulated in peripheral blood samples of septic patients with cardiac dysfunction, lipopolysaccharide (LPS)-induced cardiomyocytes, and the myocardium and peripheral blood in the septic model. Moreover, it was revealed that miR-501-5p overexpression could increase left ventricular diastolic pressure (LVDP), fractional shortening (FS), ejection fraction (EF), and maximum rate of the rise of left ventricular pressure (+dp/dt) in vivo, while it decreased the levels of myocardial injury-related indicators. In addition, LPS induction accelerated apoptosis and elevated the inflammation in HL-1 and HCM cells, which could be reversed by miR-501-5p overexpression. Mechanistically, we considered nuclear receptor subfamily 4 group A member 3 (NR4A3) as the target of miR-501-5p, and it was found that miR-501-5p prevented the binding between NR4A3 and Bcl-2. It was found that miR-501-5p exerted an inhibitory effect on cardiomyocyte apoptosis and inflammation in a NR4A3-dependent manner. Overall, our results may provide evidence for consideration of miR-501-5p in the therapy of sepsis.</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Additional file 2: Figure S2. of Upregulation of miR-501-5p activates the wnt/β-catenin signaling pathway and enhances stem cell-like phenotype in gastric cancer
No full textHoechst 33342 dye exclusion assay showing that overexpressing miR-501-5p promoted, whereas inhibition of miR-501-5p attenuated, the side-population cells in gastric cancer cells. (TIF 193 kb
Additional file 2: Table S1. of Serum microRNA miR-501-3p as a potential biomarker related to the progression of Alzheimerâs disease
No full textTop 20 deregulated serum miRNAs that were identified by NGS in the ROW discovery set after adjusting for age, sex, APOE genotype, and hemolysis ratio. Table S2. Significantly deregulated miRNAs that were identified by NGS in the temporal cortex of the ROW discovery set. Table S3. Significantly deregulated miRNAs that were identified by NGS in the temporal cortex of the ROW discovery set after adjusting for age, sex, APOE genotype, and RIN. Table S4. Significantly differentially expressed genes that were identified by NGS in hsa-miR-501-3p overexpression in cultured cells. Table S5. Gene Ontology enrichment analysis on the significantly downregulated genes in hsa-miR-501-3p overexpression in cultured cells. Table S6. Gene Ontology enrichment analysis on the significantly upregulated genes in hsa-miR-501-3p overexpression in cultured cells. (XLS 172 kb
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