1,724,640 research outputs found
Block Card 5007 Stengel Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: 5007 Stengel Avenue (Toledo, Ohio) | Dwelling | Ogontz Subdivision (Toledo, Ohio) | South Toledo Area (Toledo, Ohio) | Shotgun house
Chicago, Rock Island & Pacific (RI) 5007
No full textA photograph print showing the Chicago, Rock Island & Pacific (CRIP, RI, or ROCK) 5007, 4-8-4, Kansas City, KS
Block Card 5007 Kitchener Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Gable front houses | Folk House Style | Dwelling | Crestview Subdivision (Toledo, Ohio) | 5007 Kitchener Drive (Toledo, Ohio
Block Card 5007 Golden Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 5007 Golden Road (Toledo, Ohio) | Dwelling | Westhaven First Addition (Toledo, Ohio) | Reynolds Corners Area (Toledo, Ohio
Accelerating positive change in electronic records management: headline findings from a major research project
No full textThis article outlines 10 headline findings from a three-year multidisciplinary project, funded by the UK Arts and Humanities Research Council, on electronic records management (ERM). It also presents examples of solutions to try, or to avoid, grounded in experience. A range of strategies and tactics exist and, although their relevance and success is very contextualised, they could be adopted or adapted in many scenarios. The findings highlight the complexity of the ERM challenge, the interrelationship of people, processes and systems/technology, and the predominant and powerful role of people in accelerating positive change, or not. Two strategic conclusions are drawn which are particularly important for records professionals to address: (1) the need to articulate a vision of successful ERM and (2) the need to reinterpret records management principles in the electronic environment
Abstract 5007: WT1 promotes tumor growth and vascularization by regulating matrix metalloproteinase 9 in Ewing's sarcoma xenografts
No full textAbstract
WT1, a zinc-finger transcription factor, is expressed in tumors of varied origins including sarcomas. High level WT1 expression often correlates with poor patient survival. The role of WT1 in sarcoma biology and the mechanism by which high WT1 expression confers a poor prognosis are both unclear. The aim of this study is to investigate the effect of WT1 expression on sarcoma growth and angiogenesis. We transfected the WT1-null Ewing's sarcoma cell line SK-ES-1 with one of two major WT1 isoforms, and used shRNA to silence WT1 expression in the WT1-positive Ewing's sarcoma cell line MHH-ES. Cells were injected into the flanks of immune deficient mice and tumor growth was monitored. Tumors arising fromWT1-expressing SK-ES-1 cells grew faster than control, while tumors arising from WT1-silenced MHH-ES cells grew more slowly than control. Because our laboratory and others have shown that WT1 regulates VEGF expression, we evaluated tumor vascularity using the endothelial cell marker CD31 and the pericyte marker αSMA. In xenografted SK-ES-1 cells, quantification of CD31 positive area in WT1 expressing tumors showed 60 -70 % more compared to the controls. In contrast, CD31 expression is abolished in tumors arising from WT1-silenced MHH-ES cells. To investigate the mechanism by which WT1 affects tumor growth and vascularity, we performed a gene expression profiling in SK-ES-1 cells expressing different isoforms of WT1. We identified a number of genes up- or downregulated by WT1, including matrix metalloproteinase-9 (MMP9). Luciferase reporter assays showed that WT1 can upregulate MMP9 promoter activity in transiently transfected NIH3T3 cells. Also, immunohistochemical analysis showed increased MMP9 expression in WT1-expressing tumors. Finally, imunohistochemical analysis of primary Ewing's sarcoma samples showed correlated expression of WT1, VEGF, and MMP9. Taken together, our data suggest that WT1 promotes tumor growth and angiogenesis, perhaps via upregulation of MMP9. Increased tumor angiogenesis may lead to more aggressive tumors and a worse outcome for patients, explaining the effect of WT1 on prognosis.
Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5007. doi:10.1158/1538-7445.AM2011-500
Relationship between the [O III] lambda 5007 line and 5 GHz radio emission
No full textI have compiled observations of [O III] lambda 5007 line and 5 GHz radio emission for a large sample of GPS, CSS and FR sources. Several properties were studied and compared. The most relevant findings are that the FWHM and the luminosity of the [O III] A 5007 line are correlated with the size of the radio source. I present the data and discuss the correlations, with special focus on jet-host interaction, triggering and enhancing of [O III] A 5007 emission. (C) 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinhei
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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