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Система управления температурой камеры ПК-5005
Get PDFОдин из этапов производства интегральных микросхем – измерение при крайних температурах. Камера ПК-5005
предназначена для обеспечения определѐнного времени выдержки интегральных микросхем в условиях положительных и
отрицательных температур, с последующей подачей микросхемы на позицию контактирования с измерительным
оборудованием. В процессе испытаний при крайних температурах выявляют бракованные микросхемы, параметры которых не
соответствуют требованиям конструкторской документации. В докладе рассматриваются вопросы, связанные с разработкой
системы управления температурой для камеры ПК-5005
Block Card 5005 Cranston Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Split-Level Style | attached garage | Dwelling | Worthington Place Addition (Toledo, Ohio) | Reynolds Corners Area (Toledo, Ohio) | 5005 Cranston Drive (Toledo, Ohio
Block Card 5005 Wissman Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Cape Cod Style | 5005 Wissman Drive (Toledo, Ohio) | Dwelling | Reynolds Place Addition (Toledo, Ohio) | Reynolds Corners Area (Toledo, Ohio
Block Card 5005 Norwich Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | Dwelling | Westgate Addition (Toledo, Ohio) | South Toledo Area (Toledo, Ohio) | 5005 Norwich Road (Toledo, Ohio
Block Card 5005 Brandon Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: 5005 Brandon Road (Toledo, Ohio) | Dwelling | Westhaven First Addition (Toledo, Ohio) | Reynolds Corners Area (Toledo, Ohio) | Modern Colonial Styl
Investigate the mechanism of action of a Novel Anti-Staphylococcal Agent, SC-5005
No full text抗甲氧苯青黴素金黃色葡萄球菌因其具有對抗大多數抗生素治療的能力，使其成為全球性的健康議題。現今的處境更加凸顯發展新穎抗金黃色葡萄球菌藥物的迫切性。在我們先前的研究中篩選出一個化合物稱為SC-5005，它是抗癌藥物蕾莎瓦(Nexavar；sorafenib)的衍生物。SC-5005具有高度抗菌能力同時保持較低的細胞毒性，但其選擇性(最低抑菌濃度/細胞毒性)經計算後約39.4，與一般開發藥物所求選擇性需100稍有差距。因此我們透過修飾SC-5005的結構得到一系列的化合物，試著從這些化合物中找到更好的化合物進行開發，另一方面我們也積極尋找更適合SC-5005的藥物載體。在我們的篩選結果中找到SC-5035，但SC-5035在動物感染模式中無法表現其抗菌能力去治療小鼠的感染症而宣告失敗。而在藥物載體方面，我們找到1,2-丙二醇可以替換原本使用的藥物載體PEG-400，不會影響其藥效且可配製成較高濃度的藥劑，並減緩原載體對小鼠產生的副作用。另外我們也發現HRCA這個化合物可以大幅提升SC-5005的抗菌效果，因此更新藥物載體後將SC-5005結合HRCA進行動物實驗，結果顯示此藥物組合的確大幅提升小鼠存活率。此外我們實驗室先前的研究結果中顯示SC-5005可能藉由破壞細菌細胞膜達到抗菌的效果。在本篇研究接續發現SC-5005與SC-5035確實破壞細菌細胞膜而使得大分子螢光染劑可進入細菌體內，且藥物處理可造成金黃色葡萄球菌細胞內ATP大量流失，並在穿透是穿透式電顯實驗結果中亦明確觀察到細菌細胞膜上有孔洞產生，而SC-5005在細菌細胞膜上穿孔經Calcein leakage assay初步判定並非直接與膜上脂肪作用達成。總和實驗結果，SC-5005確可以透過修改化合物的結構得到更具開發性的藥物與合併HRCA去提升其抗菌能力並提升受MRSA感染小鼠存活率。而SC-5005以目前實驗結果推測的確會使金黃色葡萄球菌的細胞膜產生孔洞而達到抑菌的效果。Methicillin-resistant Staphylococcus aureus (MRSA) causes serious health problems worldwide due to its’ resistance to most antibiotic. This situation highlights the urgent need of developing novel anti-Staphylococcus agent. In our previous study, we identified a compound called SC-5005, a derivative of anti-cancer drug sorafenib (Nexavar). SC-5005 exhibited high antibacterial activity and low cytotoxicity. However, the selective ratio (antiproliferative activity / antibacterial activity) of SC-5005 is 39.4 only, which is lower than the ideal selective ratio value, 100. Thus, an in-house synthesized compound library of SC-5005 derivatives was screened to identify a better compound. Meanwhile, we keep optimizing the drug vehicle. During the screening, SC-5035 was identified to exhibit higher potency, but it is a pity that SC-5035 failed in in vivo assay. For the drug vehicle optimization, we found SC-5005 has higher solubility in 1,2-Propanediol which could replace our original PEG-400 based vehicle without affecting the antibacterial activity of SC-5005 and avoid PEG-400 induced inflammatory response. .Moreover, we also found a chemical called HRCA that can significantly enhance the antibacterial activity of SC-5005. On the other hand, we also try to figure out how SC-5005 act on S. aureus. Previously, our lab members found that SC-5005 might act on bacterial cell membrane. So we utilized fluorescent Live/Dead staining to observe whether bacterial cell membrane was damage after SC-5005 and SC-5035 treatment. Our result showed that our compounds indeed damage bacterial cell membrane, resulting an orange-colored bacteria. We also tested ATP leakage of S. aureus and observed that intracellular ATP level dropped dramatically after SC-5005 and SC-5035 treatment. The transmission electron microscopy image showed the pore on S. aureus cell membrane after SC-5005 treatment, but the calcein leakage assay result pointed out that the pore formation ability of SC-5005 is not through directly acting on the membrane lipids. In summary, first, we can modify the structure of SC-5005 to enhance its antibacterial activity. Second, 1,2-Propanidiol is a better vehicle for SC-5005 without the side effects of PEG400. Third, SC-5005’s antibacterial activity is by forming pores on bacterial cell membrane
Alta Capacidad Intelectual: avances en investigación e intervención
No full text29SimposioAlta Capacidad Intelectual: avances en investigación eintervenciónCoordinador/a: Sylvia Sastre i RibaEs necesario transformar el paradigma sobre la naturaleza de la Alta CapacidadIntelectual (ACI) como manifestación diferencial de la inteligencia humanaacorde con los avances científicos interdisciplinares, aportando las derivacionesnecesarias para lograr un proceso diagnóstico multidimensional y fiable ajustadoa ella. Coherentemente, la educación para la ACI junto con los servicios ysistemas que la organizan y dan soporte, deben repensarse para convertirse enla guía óptima del desarrollo del alto potencial preservando el bienestar personalde quien lo posea, ofreciendo el acceso a las oportunidades y soporte necesariospara manifestarlo con plenitud. De esta manera se puede facilitar que cristaliceen logros eminentes en cualquiera de los campos necesarios para el progresocientífico, humanístico y social. El objetivo del simposio es presentar 5comunicaciones dentro del nuevo paradigma de la ACI, basadas en estudiosempíricos que muestran resultados interdisciplinares de algunos avancesconceptuales en la regulación cognitiva y emocional en la ACI (funcionesejecutivas frías y calientes), así como en la intervención educativa eficazmediante el enriquecimiento, desde una perspectiva comparativa internacional.La primera comunicación presenta resultados sobre un programa educativoinclusivo en Alemania (LemaS) de enriquecimiento curricular. La segundacomunicación presenta resultados empíricos y de intervención socioemocionalen escolares con ACI. La tercera comunicación muestra la fiabilidad diagnósticay cambios en escolares con ACI asistentes a los programas de la Consejería deEducación en el Gobierno de Murcia. La cuarta comunicación presenta losresultados sobre el efecto de programas de enriquecimiento en el contextointernacional. La quinta comunicación presenta un modelo de relación entrefunciones ejecutivas frías y calientes que inciden en la regulación cognitiva yemocional de los escolares y jóvenes con AC
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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Advanced development of the spectrum sciences Model 5005-TF, single-event test fixture
Get PDFThis report summarizes the advanced development of the Spectrum Sciences Model 5005-TF, Single-Event Test Fixture. The Model 5005-TF uses a Californium-252 (Cf-252) fission-fragment source to test integrated circuits and other devices for the effects of single-event phenomena. Particle identification methods commonly used in high-energy physics research and nuclear engineering have been incorporated into the Model 5005-TF for estimating the particle charge, mass, and energy parameters. All single-event phenomena observed in a device under test (DUT) are correlated with an identified fission fragment, and its linear energy transfer (LET) and range in the semiconductor material of the DUT
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