1,768,027 research outputs found
Participant 491 Community Conversations Interview
No full textIn this video interview, Participant 491 shares their experience with transitioning to remote learning in the daycare center they work in. The participant says delivering food to people who have hesitancy coming out of their homes is an act of kindness they gave to others. They also discuss their preference about receiving the COVID-19 vaccine.New Jersey Department of Healt
lncRNA H19 promotes glioblastoma multiforme development by activating autophagy by sponging miR-491-5p
No full textGlioblastoma multiforme (GBM) is a malignant cancer with severely poor survival, and the cells continue to thrive during hypoxia and toxic stress through autophagy. To validate the oncogenic role of long noncoding RNA H19 in GBM progression and examine whether autophagy and/or miR-491-5p participate in the process. The expression of H19 and autophagy-related genes in GBM and healthy control tissues was assessed via quantitative polymerase chain reaction. In addition, cell viability, proliferation, apoptosis and autophagy were respectively determined via cell counting kit-8 assay, clone formation assay, flow cytometry, western blotting and green fluorescent protein–microtubule-associated protein 1 light chain 3 alpha fluorescence analysis in vitro. Furthermore, a rescue assay was performed using rapamycin or miR-491-5p antagomir to examine the role of autophagy or miR-491-5p in H19-mediated regulation of proliferation and apoptosis. RNA pull-down and dual-luciferase reporter assays were employed to analyze the interaction between H19 and miR-491-5p. Additionally, tumor growth in a xenograft-bearing mouse model and autophagy in tumor mass were analyzed in vivo. The expression H19 was increased in GBM and was positively correlated with LC3 or Beclin-1. Silencing H19 inhibited growth and promoted apoptosis in GBM cells both in vitro and in vivo, and miR-491-5p was identified as one of the important mediators. H19 regulated the autophagy signaling pathway at least partly via miR-491-5p. Increased H19 expression in GBM exerts oncogenic effects by sponging miR-491-5p and enhancing autophagy. Therefore, H19 may be explored as a target for GBM therapy.</p
Resolución UNRN N° 491/2009. Contratación Directa N° 19/2009.
No full textFil: Universidad Nacional de Río Negro (U). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución UNRN N° 491/2009. Contratación Directa N° 19/2009.fals
Philosophy [491]
No full textPhilosophy.
This manuscript is now IO Islamic B54 in the India Office collections.
[metadata: Otto Loth, A Catalogue of the Arabic Manuscripts in the Library of the India Office, (volume 1), no. 491 here with further notations and hyperlinks].
491.
B 54. Size 81/4 in. by 6 in.; foll. 143. Fifteen and seventeen lines in a page.
The concluding portion of the same Glosses.
Begins:(قال) المص الفن الثانى فى الفلكيات اى في الاحوال المنسوبة الى الفلك الخ
(=fol. 115 of the preceding MS.).
Clearly written, the greater part in Nasta’lîk. The colophon runs as follows: تحرير هذا الكتاب المسمى
الاسرار1 في تاريخ اثني عشر من شهر شعبان المعظم سنة ١١٤٩من الهجرة المباركة (r.بزبدة) بريدة.
1 This title is wrong. It belongs to another work of the same author; see Ḥ. Kh. iii. 534
Philosophy [491]
No full textPhilosophy.
This manuscript is now IO Islamic B54 in the India Office collections.
[metadata: Otto Loth, A Catalogue of the Arabic Manuscripts in the Library of the India Office, (volume 1), no. 491 here with further notations and hyperlinks].
491.
B 54. Size 81/4 in. by 6 in.; foll. 143. Fifteen and seventeen lines in a page.
The concluding portion of the same Glosses.
Begins:(قال) المص الفن الثانى فى الفلكيات اى في الاحوال المنسوبة الى الفلك الخ
(=fol. 115 of the preceding MS.).
Clearly written, the greater part in Nasta’lîk. The colophon runs as follows: تحرير هذا الكتاب المسمى
الاسرار1 في تاريخ اثني عشر من شهر شعبان المعظم سنة ١١٤٩من الهجرة المباركة (r.بزبدة) بريدة.
1 This title is wrong. It belongs to another work of the same author; see Ḥ. Kh. iii. 534
miR-491-5p functions as a tumor suppressor by targeting IGF2 in colorectal cancer
No full textLei Lu,* Ming Cai,* Meixia Peng, Fei Wang, Xiaofeng Zhai Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, China *These authors contributed equally to this work Background: Dysregulation of miRNAs is critically implicated in tumorigenesis, and aberrant expression of miR-491-5p has been reported to play a key role in initiation and progression of various cancers. However, the biological function and underlying mechanism of miR-491-5p in colorectal cancer (CRC) remain elusive.Methods: Quantitative real-time PCR (qRT-PCR) was employed to evaluate the levels of miR-491-5p and IGF2 mRNA expression in CRC tissues, cell lines and plasma. Cell counting kit-8 and colony formation assays were used to detect the effects of miR-491-5p on CRC cell growth. Luciferase reporter assays were applied to confirm the miR-491-5p target gene. In vivo experiments were conducted in nude mice.Results: miR-491-5p was found to be obviously downregulated in CRC tissues and cell lines, and decreased miR-491-5p expression level was shown to be associated with differentiation, TNM stage and poor overall survival (OS). miR-491-5p overexpression suppressed CRC cell proliferation both in vitro and in vivo. Mechanically, insulin-like growth factor 2 (IGF2) was identified to be a direct target of miR-491-5p in CRC cells, and overexpression of IGF2 rescued the miR-491-5p-induced suppression of proliferation in CRC cells. Finally, we demonstrated that plasma miR-491-5p expression was decreased in CRC when compared to healthy controls and might be an effective diagnostic biomarker for CRC.Conclusion: These data showed that miR-491-5p functioned as a tumor suppressor by targeting IGF2 in CRC, and miR-491-5p could serve as a potential diagnostic and prognostic biomarker for CRC. Keywords: miR-491-5p, IGF2, colorectal cancer, proliferation, biomarke
Preliminary lipid analyses of two Quaternary sediments from DSDP Holes 66-487 and 66-491
No full textWe investigated the solvent-extractable hydrocarbons, ketones, alcohols, and carboxylic acids of two Quaternary sediments from the Middle America Trench (Sections 487-2-3 and 491-1-5). These lipids are derived from a mixed input of autochthonous and allochthonous materials, with minor contributions from thermally mature sources. Their compositions are typical of those of immature Quaternary marine sediments, and their lipid distributions show many similarities to those of Japan Trench sediments
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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