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Sisustusmateriaalien savunmuodostus:Savukammiomenetelmä SFS 4878
No full textTutkittiin 20 kotimaisen sisustuskankaan ja 16 pehmusteen savunmuodostusta standardin SFS 4878 (yhtäpitävä standardin ASTM E-662 kanssa) mukaisella menetelmällä. Tulosten mukaan pinta-alaltaan tai tilavuudeltaan samankokoisten kappaleiden savunmuodostukseen vaikuttaa merkittävästi palavan materiaalin massa (neliömassa tai tiheys). Puuvillan palosuojauksilla (Flamentin, Pyrovatex CP ja Proban) voitiin todeta olevan edullinen vaikutus savunmuodostukseen standardin mukaisessa ulkoisessa lämpörasituksessa, joka vastaa lieskahdusta (huonetilan yleissyttymistä) välittömästi edeltävää tasoa tulipalon alkuvaiheessa. Tämän perusteella ei voida kuitenkaan päätellä, minkälainen vaikutus mainituilla palosuojauksilla on ankarammissa täyden palon vaihetta vastaavissa lämpörasituksissa. 15 mm:n paksuiset pehmeät vaahtomuovit tuottavat yleensä enemmän savua kuin kankaat pinta-alayksikköä kohden. Enemmistö tutkituista kankaista ja pehmusteista täyttää FAA:n (Federal Aviation Administration) ehdottamat vaatimukset lentokoneiden sisustusmateriaalien savunmuodostuksen suhteen. Useiden materiaalien savunmuodostusominaisuudet eivät ole yhteydessä palamistuottaiden myrkyllisyyteen. Tulosten perusteella voidaan päätellä, että tavallisilla sisustusmateriaaleilla jo pienenkin kappaleen palaessa voi huone tai huoneisto täyttyä savulla ja näkyvyys huonontua ratkaisevasti. Näyttää siltä, että useassa tapauksessa savuntiheys saavuttaa kriittisen tason nopeammin kuin myrkyllisten kaasujen pitoisuudet
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Abstract 4878: Transcriptional response to rocaglate translation inhibitors in lymphoma shows cellular adaptation through induction of stress and survival pathways
No full textAbstract Background: 40% of diffuse large B-cell lymphoma (DLBCL) patients do not achieve cure in response to the standard immunochemotherapy. Relapsed and refractory tumors respond poorly to targeted signaling inhibitors due to pathway redundancies in this genetically heterogenous disease. Pharmacologic disruption of the cap-initiation complex eIF4F is an emerging clinical treatment strategy to bypass resistance. In preclinical experiments, B-lymphomas show high susceptibility to rocaglates, natural and synthetic cap-dependent translation inhibitors. Among these compounds, eFT226 (zotatifin), is currently in phase I/II clinical evaluation for solid tumors. Rocaglate mechanisms remain incompletely defined for use in B-cell lymphoma. Recent findings in our laboratory revealed translationally mediated adaptation that increased synthesis of many targets. Proteins (i.e.CD98hc) that paradoxically increase in production contribute to persistence of cells that survive treatment. By contrast, transcriptional responses to rocaglates remain minimally studied. Here we sought to fill this gap through unbiased transcriptomics. Method: RNA sequencing (RNA-seq) was performed on zotatifin treated DLBCL cells (SU-DHL10) vs DMSO controls. Genes with a false discovery rate p-value (FDR) ≤0.05, logarithm of counts per million reads (logCPM) ≥ 0 and P value ≤0.05 were considered differentially expressed. Log2 fold change (FC) ≥ +/-2-fold for a specific gene was considered significantly differentially expressed between the two groups. Pathway analysis was performed using Gene Set Enrichment Analysis (GSEA). Results: We found 4450 differentially expressed genes, 12 significantly upregulated, and 42 significantly downregulated in response to zotatifin (FC ≥ 2). Further pathways analyses showed 4/25 gene sets significantly upregulated, and 3/22 gene sets significantly downregulated (FDR <0.25). We found significantly upregulated genes related to mechanisms stress and survival pathways including NF-kB induction by TNF signaling (normalized enriched score (NES)=2.28; p-value <0.0001), genes induced in response to hypoxia translational stress responses (NES=1.85; nominal p-value=0.008). Conclusions: These results implicate induction of specific survival pathways that induce transcriptionally mediated adaptation to the stress of rocaglate therapy, but it is unclear if these responses can result in altered protein production in the context of eIF4A inhibition. Parallel assessment of the translatome currently under analysis will provide a more complete picture of overall adaptation and provide rational combination targets for rocaglates in lymphoma as clinical development progresses. Citation Format: Paola Manara, Tyler Andrew Cunningham, Jr Jyun David Ho, Olivia B. Lightfuss, Abdessamad Youssfi Alaoui, Jonathan Harry Schatz. Transcriptional response to rocaglate translation inhibitors in lymphoma shows cellular adaptation through induction of stress and survival pathways. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 4878
Linked collectors and determiners for: Revision of Hesione Savigny in Lamarck, 1818 (Annelida, Errantia, Hesionidae).
No full textNatural history specimen data linked to collectors and determiners held within, "Revision of Hesione Savigny in Lamarck, 1818 (Annelida, Errantia, Hesionidae)". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/6c3d39df-7484-4878-8952-9c6a0d926465">https://bionomia.net/dataset/6c3d39df-7484-4878-8952-9c6a0d926465</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/6c3d39df-7484-4878-8952-9c6a0d926465">https://gbif.org/dataset/6c3d39df-7484-4878-8952-9c6a0d926465</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: HUFABC - Herbário da UFABC.
No full textNatural history specimen data linked to collectors and determiners held within, "HUFABC - Herbário da UFABC". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/a5e26562-5429-4878-a0d4-5cef3d5cc923">https://bionomia.net/dataset/a5e26562-5429-4878-a0d4-5cef3d5cc923</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/a5e26562-5429-4878-a0d4-5cef3d5cc923">https://gbif.org/dataset/a5e26562-5429-4878-a0d4-5cef3d5cc923</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: Begonia elachista Moonlight & Tebbitt sp. nov., an enigmatic new species and a new section of Begonia (Begoniaceae) from Peru.
No full textNatural history specimen data linked to collectors and determiners held within, "Begonia elachista Moonlight & Tebbitt sp. nov., an enigmatic new species and a new section of Begonia (Begoniaceae) from Peru". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/71d88e93-f830-4878-832e-3e10e3e80f61">https://bionomia.net/dataset/71d88e93-f830-4878-832e-3e10e3e80f61</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/71d88e93-f830-4878-832e-3e10e3e80f61">https://gbif.org/dataset/71d88e93-f830-4878-832e-3e10e3e80f61</a>. Formatted as a Frictionless Data package
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Linked collectors and determiners for: Begonia elachista Moonlight & Tebbitt sp. nov., an enigmatic new species and a new section of Begonia (Begoniaceae) from Peru.
No full textNatural history specimen data linked to collectors and determiners held within, "Begonia elachista Moonlight & Tebbitt sp. nov., an enigmatic new species and a new section of Begonia (Begoniaceae) from Peru". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/71d88e93-f830-4878-832e-3e10e3e80f61">https://bionomia.net/dataset/71d88e93-f830-4878-832e-3e10e3e80f61</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/71d88e93-f830-4878-832e-3e10e3e80f61">https://gbif.org/dataset/71d88e93-f830-4878-832e-3e10e3e80f61</a>. Formatted as a Frictionless Data package
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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