1,724,141 research outputs found
Block Card 4840 Elm Place
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 4840 Elm Place (Toledo, Ohio) | Dwelling | Deveaux Area (Toledo, Ohio
John Deere 4840 Tractor Using GreenStar GPS Auto Guidance
No full textThis video, from Big Tractor Power, features a John Deere 4840 tractor using GreenStar GPS auto guidance. This video shows "... time [spent] out in the field with 180 pto hp John Deere 4840 tractor and 16 row 7200 MaxEmerge II planting seeding organic soybeans. This video shares specifications of the tractor and planter as well as climbing up in the 4840 cab to see the auto guidance GPS system at work." This video runs 13:39 minutes in length.&nbsp
Block Card 4840 Thobe Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: attached garage | Ranch houses | 4840 Thobe Road (Toledo, Ohio) | Dwelling | Edgewood Addition (Toledo, Ohio) | Reynolds Corners Area (Toledo, Ohio
Block Card 4840 Airport Highway
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Crestwood Realty (Toledo, Ohio) | Model houses | Ranch houses | 4840 Airport Highway (Toledo, Ohio) | Westgate Addition (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
HE 0557-4840 : Ultra-metal-poor and carbon-rich
No full textWe report the discovery and high-resolution, high-S/N spectroscopic analysis of the ultra-metal-poor red giant HE 0557-4840, which is the third most heavy-element-deficient star currently known. Its atmospheric parameters are Teff=4900 K, logg=2.2, and [Fe/H]=-4.75. This brings the number of stars with [Fe/H]<-4.0 to three, and the discovery of HE 0557-4840 suggests that the metallicity distribution function of the Galactic halo does not have a ``gap'' between [Fe/H]=-4.0, where several stars are known, and the two most metal-poor stars, at [Fe/H]~-5.3. HE 0557-4840 is carbon rich ([C/Fe]=+1.6), a property shared by all three objects with [Fe/H]<-4.0, suggesting that the well-known increase of carbon relative to iron with decreasing [Fe/H] reaches its logical conclusion (ubiquitous carbon richness) at lowest abundance. We also present abundances (nine) and limits (nine) for a further 18 elements. For species having well-measured abundances or strong upper limits, HE 0557-4840 is ``normal'' in comparison with the bulk of the stellar population at [Fe/H]~-4.0, with the possible exception of Co. We discuss the implications of these results for chemical enrichment at the earliest times, in the context of single- (``mixing and fallback'') and two-component enrichment models. While neither offers a clear solution, the latter appears closer to the mark. Further data are required to determine the oxygen abundance and improve that of Co, and hence more strongly constrain the origin of this object. Based on observations collected at ANU's 2.3 m telescope on Siding Spring Mountain, Australia, and European Southern Observatory, Paranal, Chile (proposal 276.D-5041).</p
[Veto of H. 4840, R-343]
No full textThis veto message from Governor Mark Sanford vetoes H. 4840, R-343, a bill that would allow corporations and individual to take a nonrefundable tax credit of 100 percent against state income taxes or insurance premium taxes for contributing to the newly created "Industry Partnership Fund" - a fund created to distribute dollars to each of the South Carolina Research Innovation Centers by the South Carolina Research Authority
Linked collectors and determiners for: Arizona State University Lois B. O'Brien Collection.
No full textNatural history specimen data linked to collectors and determiners held within, "Arizona State University Lois B. O'Brien Collection". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/78a151c6-19aa-4840-86a7-6fbd84acccce">https://bionomia.net/dataset/78a151c6-19aa-4840-86a7-6fbd84acccce</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/78a151c6-19aa-4840-86a7-6fbd84acccce">https://gbif.org/dataset/78a151c6-19aa-4840-86a7-6fbd84acccce</a>. Formatted as a Frictionless Data package
Abstract 4840: 2-Deoxy-D-glucose induces autophagy through endoplasmic reticulum stress rather than by lowering ATP
No full textAbstract
Based on emerging evidence that oncogenes direct increased glucose metabolism in tumor cells, the glycolytic inhibitor, 2-deoxy-D-glucose (2-DG) appears to be a promising drug to selectively target cancer cells. 2-DG however, not only blocks glycolysis and reduces cellular ATP production but also interferes with N-linked glycosylation, thereby inducing endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). Both bioenergetic challenge and ER stress/UPR have been shown to activate autophagy, a bulk cellular degradation process that plays either a pro- or anti-death role. This led us to investigate the following, 1) which pathway that 2-DG interferes with is responsible for stimulating autophagy, and 2) the role of autophagy in modulating 2-DG-induced cellular responses and toxicity. In four cancer cell lines (1420, MDA-MB-435, SKBR3 and T98G) we find that 2-DG upregulates autophagy (LC3B II), increases the ER stress/UPR markers, Grp78 and CHOP, and lowers ATP levels. Addition of exogenous mannose reverses 2-DG-induced autophagy and expression of GRP78 and CHOP but does not recover the lowered levels of ATP. Additionally, when autophagy is either blocked or enhanced by 3-methyladenine (3-MA) or rapamycin, respectively, 3-MA increases whereas rapamycin reduces cancer cell sensitivity to 2-DG. In support of these results, knock down of autophagy-related gene 7 (Atg7) with small interfering RNAs (siRNAs) increases sensitivity to 2-DG in 1420 cells, which correlates with increases in the ER stress/UPR markers as well as the apoptotic marker, cleaved caspase 3. Overall, these results indicate that the major mechanism by which 2-DG stimulates autophagy is through ER stress/UPR, and autophagy protects cells from 2-DG-induced toxicity through relief of ER stress. Thus, combining autophagy inhibitors with 2-DG may be useful clinically.
Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4840.</jats:p
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