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Southern (SOU) 4821
No full textA photograph print showing the Southern (SOU) 4821, 2-8-2 (class Ms-4), Charlotte, NC
Block Card 4821 Brott Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling | 4821 Brott Road (Toledo, Ohio) | Ranch houses | Garrison Place (Toledo, Ohio) | Deveaux Area (Toledo, Ohio) | West Toledo area (Toledo, Ohio
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Abstract 4821: Exploring the role of a solid-like condensate in breast and prostate cancer
No full textAbstract Cancer cells are exposed to harsh environmental conditions, which they adapt to by engaging various stress response pathways. A common cellular response to these stressors is the assembly of membraneless compartments known as biomolecular condensates. Our lab discovered one such pathway where exposure to environmental stressors reversibly converts nucleoli into solid-like condensates known as Amyloid bodies (A-bodies). A-bodies induce a state of cellular dormancy by sequestering in an amyloid-like state key proteins involved in processes such as DNA replication and cell cycle progression. In vitro experiments showed that suppressing A-body formation in cancer cell lines accelerates tumorigenesis, suggesting that system-wide amyloidogenesis is a mechanism of tumor suppression. The goal of this project was to investigate how A-bodies correlate with tumorigenesis in the context of human tissues. Using formalin-fixed paraffin embedded (FFPE) sections of breast invasive ductal carcinoma and prostate adenocarcinoma, we first confirmed the presence of A-bodies in tumors by staining with the amyloidophilic dye Amylo-glo. In agreement with in vitro data in breast and prostate cancer cell lines, immunohistochemical staining further showed these condensates contain known A-body constituent proteins. Co-staining tissues with Amylo-glo and the proliferation marker Ki67 revealed a negative correlation between A-bodies and cell proliferation, supporting the hypothesis that A-bodies suppress cell growth. Finally, tissue staining comparing primary tumors with distant metastases suggests that A-body biogenesis is reduced in the progression to metastatic disease. Together, our preliminary data presents a biomolecular condensate which can be visualized in human tissues and inversely correlates with cell proliferation. Future directions include examining additional tumor types for the presence of A-bodies and testing the correlation between A-bodies and other markers of proliferation, cell cycle arrest, and environmental stress. Citation Format: Alexander Grunfeld, Michael Bokros, Chloe Kirk, Stephen Lee. Exploring the role of a solid-like condensate in breast and prostate cancer. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 4821
Block Card 4821 Bowser Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling | 4821 Bowser Drive (Toledo, Ohio) | Bungalow Style | Craftsman Style | Deveaux Area (Toledo, Ohio) | West Toledo area (Toledo, Ohio
[Veto of H. 4821, R-430]
No full textThis veto message from Governor Mark Sanford vetoes H. 4821, R-430, a bill containing various sections relating to licensure requirements for optometrists, licensure requirements for hair braiders, and registration requirements for cardiovascular invasive specialists
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
4821. Marin Sanudo, dit le jeune, Diarii
No full text4821. Marin Sanudo, dit le jeune, Diarii. In: Molinier Auguste. Les Sources de l'histoire de France - Des origines aux guerres d'Italie (1494). V. Introduction générale - Les Valois (suite), Louis XI et Charles VIII (1461-1494) Paris : A. Picard et fils, 1904. p. 64
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