1,724,748 research outputs found

    Block Card 4735 Ryan Court

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    This image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Split-Level Style | 4735 Ryan Court (Toledo, Ohio) | Dwelling | Orchard Dale Estates (Toledo, Ohio) | South Toledo Area (Toledo, Ohio

    MicroRNA-4735-3p Facilitates Ferroptosis in Clear Cell Renal Cell Carcinoma by Targeting SLC40A1

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    OBJECTIVE: Clear cell renal cell carcinoma (ccRCC) is the major histopathological subtype of renal cancer, and ferroptosis is implicated in the pathogenesis of ccRCC. The present study was aimed at investigating the role and underlying mechanisms of microRNA-4735-3p (miR-4735-3p) in ccRCC. METHODS: Human ccRCC cell lines were transfected with the miR-4735-3p mimic or inhibitor to manipulate the expression of miR-4735-3p. Cell proliferation, colony formation, cell migration, cell invasion, cell death, oxidative stress, lipid peroxidation, and iron metabolism were determined. To validate the necessity of solute carrier family 40 member 1 (SLC40A1), human ccRCC cell lines were overexpressed with SLC40A1 using adenoviral vectors. RESULTS: miR-4735-3p expression was reduced in human ccRCC tissues and cell lines but elevated upon ferroptotic stimulation. The miR-4735-3p mimic increased, while the miR-4735-3p inhibitor decreased oxidative stress, lipid peroxidation, iron overload, and ferroptosis of human ccRCC cell lines. Mechanistic studies identified SLC40A1 as a direct target of miR-4735-3p, and SLC40A1 overexpression significantly attenuated iron overload and ferroptosis in the miR-4735-3p mimic-treated human ccRCC cell lines. CONCLUSION: miR-4735-3p facilitates ferroptosis and tumor suppression in ccRCC by targeting SLC40A1

    Block Card 4735 Vogel Drive

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    This image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Split-Level Style | Dwelling | 4735 Vogel Drive (Toledo, Ohio) | Elmhurst Park Addition (Toledo, Ohio) | Deveaux Area (Toledo, Ohio) | West Toledo (Toledo, Ohio

    Block Card 4735 Harbord Drive

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    This image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling | 4735 Harboard Drive (Toledo, Ohio) | Ranch houses | Monroe Acres (Toledo, Ohio) | Franklin Park Area (Toledo, Ohio) | West Toledo Area (Toledo, Ohio

    Block Card 4735 285th Street

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    This image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling | 4735 285th Street (Toledo, Ohio) | Parkview Addition (Toledo, Ohio) | Point Place (Toledo, Ohio) | North Toledo Area (Toledo, Ohio) | Folk House Styl

    Block Card 4735 Oak Glen Drive

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    This image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch Style | Dwelling | 4735 Oak Glen (Toledo, Ohio) | Elmhurst Park Addition (Toledo, Ohio) | Deveaux Area (Toledo, Ohio) | West Toledo (Toledo, Ohio

    Linked collectors and determiners for: Museu Darder de Banyoles.

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    Natural history specimen data linked to collectors and determiners held within, "Museu Darder de Banyoles". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/8670893a-08ad-4735-8c18-eb088443ccd6">https://bionomia.net/dataset/8670893a-08ad-4735-8c18-eb088443ccd6</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/8670893a-08ad-4735-8c18-eb088443ccd6">https://gbif.org/dataset/8670893a-08ad-4735-8c18-eb088443ccd6</a>. Formatted as a Frictionless Data package

    Linked collectors and determiners for: Museu Darder de Banyoles.

    No full text
    Natural history specimen data linked to collectors and determiners held within, "Museu Darder de Banyoles". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/8670893a-08ad-4735-8c18-eb088443ccd6">https://bionomia.net/dataset/8670893a-08ad-4735-8c18-eb088443ccd6</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/8670893a-08ad-4735-8c18-eb088443ccd6">https://gbif.org/dataset/8670893a-08ad-4735-8c18-eb088443ccd6</a>. Formatted as a Frictionless Data package

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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