1,724,922 research outputs found
AUTOUR ÉPOQUE 1 : Autour du Lycée, roman d'Ines Orchani
No full textISSN : 2739-4689 ISBN : 978-2-490780-19-
AROUND AGE 1 : Around the High School, a novel, by Ines Orchani
No full textISSN : 2739-4689 ISBN : 978-2-490780-19-
Linked collectors and determiners for: Notogaster, a new genus of Microgastrinae (Hymenoptera: Braconidae) from New Zealand.
No full textNatural history specimen data linked to collectors and determiners held within, "Notogaster, a new genus of Microgastrinae (Hymenoptera: Braconidae) from New Zealand". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/8706a322-fb1f-4689-873a-e03bf02c5a50">https://bionomia.net/dataset/8706a322-fb1f-4689-873a-e03bf02c5a50</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/8706a322-fb1f-4689-873a-e03bf02c5a50">https://gbif.org/dataset/8706a322-fb1f-4689-873a-e03bf02c5a50</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: A new genus, new species and taxonomic notes on American Cerambycinae (Coleoptera, Cerambycidae).
No full textNatural history specimen data linked to collectors and determiners held within, "A new genus, new species and taxonomic notes on American Cerambycinae (Coleoptera, Cerambycidae)". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/14ec68a3-1d9a-4689-9eb4-fc1d3fce4e54">https://bionomia.net/dataset/14ec68a3-1d9a-4689-9eb4-fc1d3fce4e54</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/14ec68a3-1d9a-4689-9eb4-fc1d3fce4e54">https://gbif.org/dataset/14ec68a3-1d9a-4689-9eb4-fc1d3fce4e54</a>. Formatted as a Frictionless Data package
Concurrent Targeting of KRAS and AKT by MiR-4689 Is a Novel Treatment Against Mutant KRAS Colorectal Cancer
No full textKRAS mutations are a major cause of drug resistance to molecular-targeted therapies. Aberrant epidermal growth factor receptor (EGFR) signaling may cause dysregulation of microRNA (miRNA) and gene regulatory networks, which leads to cancer initiation and progression. To address the functional relevance of miRNAs in mutant KRAS cancers, we transfected exogenous KRASG12V into human embryonic kidney 293 and MRC5 cells with wild-type KRAS and BRAF genes, and we comprehensively profiled the dysregulated miRNAs. The result showed that mature miRNA oligonucleotide (miR)-4689, one of the significantly down-regulated miRNAs in KRASG12V overexpressed cells, was found to exhibit a potent growth-inhibitory and proapoptotic effect both in vitro and in vivo. miR-4689 expression was significantly down-regulated in cancer tissues compared to normal mucosa, and it was particularly decreased in mutant KRAS CRC tissues. miR-4689 directly targets v-ki-ras2 kirsten rat sarcoma viral oncogene homolog (KRAS) and v-akt murine thymoma viral oncogene homolog 1(AKT1), key components of two major branches in EGFR pathway, suggesting KRAS overdrives this signaling pathway through inhibition of miR-4689. Overall, this study provided additional evidence that mutant KRAS functions as a broad regulator of the EGFR signaling cascade by inhibiting miR-4689, which negatively regulates both RAS/mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/AKT pathways. These activities indicated that miR-4689 may be a promising therapeutic agent in mutant KRAS CRC
Additional file 2 of CircPTPN22 modulates T-cell activation by sponging miR-4689 to regulate S1PR1 expression in patients with systemic lupus erythematosus
No full textAdditional file 2: Supplementary Figure 2. The relationship between miR-4689 expression and SLEDAI score in SLE patients. A. SLEDAI score and miR-4689 expression in SLE patients. B. Correlation analysis of miR-4689 expression and SLEDAI score. SLEDAI, Systemic Lupus Erythematosus Disease Activity Index; SLE, systemic lupus erythematosus; ****P< 0.0001
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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