1,727,555 research outputs found
Long intergenic non-protein coding RNA 02570 promotes nasopharyngeal carcinoma progression by adsorbing microRNA miR-4649-3p thereby upregulating both sterol regulatory element binding protein 1, and fatty acid synthase
No full textOur previous studies have elucidated a possible connection between long intergenic non-protein coding RNA 2570 (LINC02570) and nasopharyngeal carcinoma (NPC). However, the precise mechanism by which LINC02570 promotes NPC remains unknown. We used quantitative polymerase chain reaction (qPCR) to detect LINC02570 expression in nasopharyngeal cell lines, NPC tissues, and chronic rhinitis tissues. Subcellular LINC02570 localization was confirmed by fluorescence in situ hybridization (FISH). The effects of LINC02570 stable knockdown and overexpression on viabillity, proliferation, migration, and invasion were analyzed using 3-(4,5-Dimethyl-2-Thiazolyl)-2,5-Diphenyl-2-H-Tetrazolium bromide (MTT), a colorimetric focus-formation assay, a wound healing assay, and transwell assays. RNA crosstalk analysis in silico predicted microRNA-4649-3p (miR-4649-3p) binding to LINC02570 or sterol regulatory element binding transcription factor 1 (SREBF1). A dual luciferase reporter assay was used to confirm potential interactions. Sterol regulatory element binding protein 1 (SREBP1) and fatty acid synthase (FASN) expression were detected by western blotting. The results suggest that LINC02570 is upregulated in late clinical stage NPC patients, and promotes NPC progression by adsorbing miR-4649-3p to up-regulate SREBP1 and FASN. This study elucidates a potential chemotherapeutic target involved in lipid metabolism in NPC.</p
Stellar Population Synthesis of the Elliptical Galaxy NGC 4649
No full textWe investigated population of the elliptical galaxy NGC 4649 using the spectral synthesis technique based on the linear program in the spectral regions between 3160Å to 10800Å. We used the spectral data of stars obtained by Gunn & Stryker (1983), and the integrated spectrum of NGC 4649 observed by Bertola et al. (1982). Among four models with different main sequence turn-off points, G8-K0V main sequence turn-off model is best fitted to the integrated spectrum of NGC 4649. We also found that super metal rich K giants are needed to describe the absorption lines in the long wavelength regions of integrated spectrum of NGC 4649. The mass to absolute light ratio obtained from the spectral synthesis is ~20 similar to those calculated dynamically
Block Card 4649 Clover Lane
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 4649 Clover Lane (Toledo, Ohio) | Dwelling | Greenbush Knolls Addition (Toledo, Ohio) | Trilby Area (Toledo, Ohio)
Block Card 4649 Ryan Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 4649 Ryan Road (Toledo, Ohio) | Dwelling | Orchard Dale Estates (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
AGN-Induced Cavities in NGC 1399 and NGC 4649
Get PDFABSTRACT We present an analysis of archival Chandra and VLA observations of the E0 galaxy NGC 1399 and the E2 galaxy NGC 4649 in which we investigate cavities in the surrounding X-ray emitting medium caused by the central AGN. We calculate the jet power required for the AGN to evacuate these cavities and find values of ∼ 8 × 10 41 erg s −1 and ∼ 14 × 10 41 erg s −1 for the lobes of NGC 1399 and ∼ 7 × 10 41 erg s −1 and ∼ 6 × 10 41 erg s −1 for those of NGC 4649. We also calculate the k/f values for each cavity, where k is the ratio of the total particle energy to that of electrons radiating in the range of 10 MHz to 10 GHz, and f is the volume filling factor of the plasma in the cavity. We find that the values of k/f for the lobes of NGC 1399 are ∼ 93 and ∼ 190, and those of the lobes of NGC 4649 are ∼ 15000 and ∼ 12000. We conclude that the assumed spectrum describes the electron distribution in the lobes of NGC 1399 reasonably well, and that there are few entrained particles. For NGC 4649, either there are many entrained particles or the model spectrum does not accurately describe the population of electrons
Block Card 4649 N. May Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 4649 N. May Avenue (Toledo, Ohio) | Dwelling | Fuller's Springtime Addition (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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