1,724,368 research outputs found
Colebeck, William George Frederick, 4620
This record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/377978Surname: COLEBECK
Given Name(s) or Initials: WILLIAM GEORGE FREDERICK
Military Service Number or Last Known Location: 4620
Missing, Wounded and Prisoner of War Enquiry Card Index Number: 25500191791
Item: [2016.0049.10272] "Colebeck, William George Frederick, 4620
Begonnen mit Zugangs-Nr. F 4620 am 28.2.56
BEGONNEN MIT ZUGANGS-NR. F 4620 AM 28.2.56
Zugangs- und Abgangsverzeichnis der Abteilung F (-)
Begonnen mit Zugangs-Nr. F 4620 am 28.2.56 (8) ( - )
Cover ( - )
F 4620 bis F 4699 (2)
F 4700 bis F 4799 (12)
F 4800 bis F 4899 (26)
F 4900 bis F 4999 (40)
F 5000 bis F 5099 (54)
F 5100 bis F 5170 (69
Block Card 4620 Commonwealth Avenue
This image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling (Toledo, Ohio) | Tudor Cottage style | Homeville Subdivision (Toledo, Ohio) | Willys Park area (Toledo, Ohio) | West Toledo (Toledo, Ohio) | 4620 Commonwealth Avenue (Toledo, Ohio
Block Card 4620 Vermaas Avenue
This image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: dwelling | 4620 Vermaas Avenue (Toledo, Ohio) | Williamsburg Style | North Toledo (Toledo, Ohio) | Willys Park area (Toledo, Ohio) | Alfred Bailey Addition (Toledo, Ohio
Linked collectors and determiners for: Colección de cucarachas (Insecta: Blattodea) del Centro de Colecciones Biológicas de la Universidad del Magdalena.
Natural history specimen data linked to collectors and determiners held within, "Colección de cucarachas (Insecta: Blattodea) del Centro de Colecciones Biológicas de la Universidad del Magdalena". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/cb48f2fc-ca9a-4620-b00b-483494022d86">https://bionomia.net/dataset/cb48f2fc-ca9a-4620-b00b-483494022d86</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/cb48f2fc-ca9a-4620-b00b-483494022d86">https://gbif.org/dataset/cb48f2fc-ca9a-4620-b00b-483494022d86</a>. Formatted as a Frictionless Data package
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Abstract 4620: Exploring the role of GHRH antagonist MIA-602 in overcoming doxorubicin resistance in acute myeloid leukemia
Abstract Acute Myeloid Leukemia (AML) is characterized by the uncontrolled proliferation of immature hematopoietic progenitors, often associated with a poor prognosis. Conventional therapies involve chemotherapy and bone marrow stem cell transplantation. The growth hormone releasing hormone receptor (GHRH-R) antagonist MIA-602 has exhibited inhibitory effects on the growth of various human cancer cell lines, including AML cells. This study aimed to investigate the impact of MIA-602 alone and in combination with doxorubicin on three doxorubicin-resistant AML cell lines, K-562, U-937, and KG-1A. Initial examinations confirmed the presence of GHRH receptors in both wild-type and doxorubicin-resistant cell lines through western blot analysis. Doxorubicin was administered at concentrations of 0.005, 0.01, and 0.05 μg/ml, while MIA-602 was used at 5 μmol/L. Subsequent experiments involved culturing both wild-type and doxorubicin-resistant clones with MIA-602 at concentrations ranging from 0.05 μmol/L to 5 μmol/L for 24 and 48 hours. The results revealed a significant, dose- and time-dependent reduction in cell proliferation across all six cell lines. Both wild-type and doxorubicin-resistant clones exhibited a comparable decrease in cell proliferation when exposed to MIA-602 at concentrations greater than 0.05 μmol/L (p < 0.05) after 24 and 48 hours. In conclusion, our study demonstrates that these three AML cell lines and their doxorubicin-resistant clones remain susceptible to GHRH antagonist MIA-602. These findings may pave the way for the development of novel therapies or drug combinations using GHRH antagonists such as MIA-602 for treating AML. This is of particular interest for those who are resistant to conventional chemotherapy, further broadening the spectrum of treatment options available. Additional investigations are warranted to progress these findings to in vivo xenograft models. Citation Format: Simonetta I. Gaumond, Joel Costoya, Andrew V. Schally, Joaquin J. Jimenez. Exploring the role of GHRH antagonist MIA-602 in overcoming doxorubicin resistance in acute myeloid leukemia [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 4620
Linked collectors and determiners for: Aphyllophorales Fennoscandiae orientalis.
Natural history specimen data linked to collectors and determiners held within, "Aphyllophorales Fennoscandiae orientalis". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/0786c87e-0e18-4620-9633-d3a358e1ed2c">https://bionomia.net/dataset/0786c87e-0e18-4620-9633-d3a358e1ed2c</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/0786c87e-0e18-4620-9633-d3a358e1ed2c">https://gbif.org/dataset/0786c87e-0e18-4620-9633-d3a358e1ed2c</a>. Formatted as a Frictionless Data package
Going Beyond Counting First Authors in Author Co-citation Analysis
The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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