1,730,252 research outputs found
Union Pacific (UP) 4601
No full textA photograph print showing Union Pacific (UP) 4601, 0-6-0, switch engine, Topeka, KS
Pacific Electric Railway (PE) 1628 & 4601 Wreck
No full textA photograph print showing the Pacific Electric Railway wreck of 1628 electric switcher and 4601 electric motor coach, head-on collision in dense fog, killing the 4601 motoman and injuring 60 others. Occured in trahs dump of Athens, CA, 1945
Block Card 4601 Harbord Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 4601 Harboard Drive (Toledo, Ohio) | Dwelling | Monroe Acres (Toledo, Ohio) | Franklin Park Area (Toledo, Ohio) | Trilby Area (Toledo, Ohio)
Block Card 4601 Oakridge Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | Dwelling | 4601 Oakridge Drive (Toledo, Ohio) | Forest Grove Addition (Toledo, Ohio) | Trilby Area (Toledo, Ohio)) | West Toledo Area (Toledo, Ohio
Identification, characterization and potent antitumor activity of ECO-4601, a novel peripheral benzodiazepine receptor ligand.
No full textInternational audiencePURPOSE: ECO-4601 is a structurally novel farnesylated dibenzodiazepinone discovered through DECIPHER technology, Thallion's proprietary drug discovery platform. The compound was shown to have a broad cytotoxic activity in the low micromolar range when tested in the NCI 60 cell line panel. In the work presented here, ECO-4601 was further evaluated against brain tumor cell lines. Preliminary mechanistic studies as well as in vivo antitumor evaluation were performed. METHODS: Since ECO-4601 has a benzodiazepinone moiety, we first investigated if it binds the central and/or peripheral benzodiazepine receptors. ECO-4601 was tested in radioligand binding assays on benzodiazepine receptors obtained from rat hearts. The ability of ECO-4601 to inhibit the growth of CNS cancers was evaluated on a panel of mouse, rat and human glioma cell lines using a standard MTT assay. Antitumor efficacy studies were performed on gliomas (rat and human), human breast and human prostate mouse tumor xenografts. Antitumor activity and pharmacokinetic analysis of ECO-4601 was evaluated following intravenous (i.v.), subcutaneous (s.c.), and intraperitoneal (i.p.) bolus administrations. RESULTS: ECO-4601 was shown to bind the peripheral but not the central benzodiazepine receptor and inhibited the growth of CNS tumor cell lines. Bolus s.c. and i.p. administration gave rise to low but sustained drug exposure, and resulted in moderate to significant antitumor activity at doses that were well tolerated. In a rat glioma (C6) xenograft model, ECO-4601 produced up to 70% tumor growth inhibition (TGI) while in a human glioma (U-87MG) xenograft, TGI was 34%. Antitumor activity was highly significant in both human hormone-independent breast (MDA-MB-231) and prostate (PC-3) xenografts, resulting in TGI of 72 and 100%, respectively. On the other hand, i.v. dosing was followed by rapid elimination of the drug and was ineffective. CONCLUSIONS: Antitumor efficacy of ECO-4601 appears to be associated with the exposure parameter AUC and/or sustained drug levels rather than C (max). These in vivo data constitute a rationale for clinical studies testing prolonged continuous administration of ECO-4601
Block Card 4601 S. May Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: 4601 S. May Avenue (Toledo, Ohio) | Dwelling | Fuller's Springtime Addition (Toledo, Ohio) | South Toledo Area (Toledo, Ohio) | Colonial Styl
Experimental Investigations On Mechanical Wear And Corrosion Behaviour Of Sintered Atomet 4601 Based Hybrid Alloys
No full textPowder metallurgy enables the development of new materials to manufacture products for applications requiring unique properties. The present research initially investigates the mechanical and tribological behaviour of powder metallurgy alloys made from ATOMET 4601 prealloyed powder and varying amounts of elemental carbon (0, 0.5, and 1.0 wt%) as reinforcement. ATOMET 4601 is a high-strength, water-atomized prealloyed powder capable of being compressed to higher densities, with applications in producing near-net or net-shaped parts for the industrial field.
Mechanical behaviour studies on sinter-forged ATOMET 4601, ATOMET 4601+0.5C, and ATOMET 4601+1.0C alloy steels revealed increased hardness, tensile strength, and impact strength, with ATOMET 4601+1.0C having the highest strength. Fracture analysis of ATOMET 4601, ATOMET 4601+0.5C, and ATOMET 4601+1.0C tensile test specimens revealed ductile, quasi-static, and brittle fractures, respectively.
Subsequently, dry sliding wear studies were conducted on the above alloys which address the effect of load (15 to 50 N) and speed (300 to 1200 rpm) on wear behaviour using a pin-on-disc tribometer. ATOMET 4601+0.5C and ATOMET 4601+1.0C have exhibited a lesser wear rate due to their higher hardness and strength. A soft ferritic–pearlite phase matrix and lesser hardness could have caused a higher wear rate in the base alloy. Carbide and oxide formation caused a lower wear rate in both carbon-reinforced alloys. Both load and speed significantly affected the coefficient of friction in all three alloys.
Based on the mechanical and tribological test results, the research focus was narrowed down to develop and study the performance of ATOMET 4601+0.35C (Hybrid alloy 1) and ATOMET 4601+0.35C+0.25Mn+0.1Si+0.9Cr (Hybrid alloy 2) which can replace products made from conventional medium carbon steel (AISI 1035) and EN24 wrought steel respectively. The sintered preforms are considered to study the formability parameters like true lateral strain, true height strain, relative density, and hardness. The research on workability revealed that the hybrid alloy 2 test specimens have undergone lesser densification and deformation due to the work hardening mechanism caused by the addition of alloying elements.
Microstructures of the cold upset test specimens are correlated with the densification behaviour. Further, the study investigated the corrosion behaviour of sintered hybrid preforms with different densities in an 18% HCl corrosive solution for 25, 50, 75 and 100 hours. Results showed that hybrid alloy 2 had a lesser corrosion rate than hybrid alloy 1 due to the presence of different alloying elements. The XRD, optical, and SEM images of corroded surfaces of the test specimens were correlated with corrosion mechanisms.
After understanding the better strength and corrosion resistance of hybrid alloy 2, the wear test was conducted for hybrid alloy 2. Dry sliding wear studies on sintered hybrid alloy 2 revealed its lowest wear rate among all the alloys. Coefficient of friction is higher than the base alloy and lesser than ATOMET 4601+1.0C at the lowest load conditions. Finally, empirical relations were developed, and model adequacy was checked using ANOVA. Thus, the research provides insights to assist the powder metallurgy designer in developing the high performance materials for functional parts in engineering industries
Οι εταιρικοί μετασχηματισμοί υπό το Ν. 4601/2019 και τα ανακύπτοντα φορολογικά ζητήματα
Get PDFΔιπλωματική εργασία--Πανεπιστήμιο Μακεδονίας, Θεσσαλονίκη, 2020.Σκοπός της παρούσας διπλωματικής εργασίας είναι η προσέγγιση του νέου Ν. 4601/2019, ο οποίος εισάγει για πρώτη φορά στην ελληνική έννομη τάξη ένα ολοκληρωμένο πλέγμα ρυθμίσεων για τους μετασχηματισμούς των εμπορικών εταιριών. Αρχικά γίνεται μια απαραίτητη αναφορά στις βασικές μορφές μετασχηματισμού, ενώ αμέσως μετά εξετάζονται οι παθογένειες του προϊσχύσαντος δικαίου. Έπειτα, γίνεται μία ευσύνοπτη παρουσίαση των βασικών γνωρισμάτων του Ν. 4601/2019 και των αποτελεσμάτων αυτού. Ένα άλλο σημαντικό θέμα που εξετάζεται είναι η παρέμβαση του φορολογικού δικαίου στους εταιρικούς μετασχηματισμούς, ενόψει του άρθρου 4 του Ν. 4601/2019, ενώ συμπερασματικά καταδεικνύεται η ανάγκη μεταρρύθμισης του φορολογικού πλαισίου που διέπει τους μετασχηματισμούς με σκοπό την εναρμόνισή του με το Ν. 4601/2019
- …
