1,724,033 research outputs found
Linked collectors and determiners for: NCSM Vertebrate Paleontology Collection.
No full textNatural history specimen data linked to collectors and determiners held within, "NCSM Vertebrate Paleontology Collection". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/5f1568db-5d5b-4597-9c66-dfbd0d7ddd7b">https://bionomia.net/dataset/5f1568db-5d5b-4597-9c66-dfbd0d7ddd7b</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/5f1568db-5d5b-4597-9c66-dfbd0d7ddd7b">https://gbif.org/dataset/5f1568db-5d5b-4597-9c66-dfbd0d7ddd7b</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: Contribution à la connaissance des Tetrigidae (Orthoptera) de Guyane.
No full textNatural history specimen data linked to collectors and determiners held within, "Contribution à la connaissance des Tetrigidae (Orthoptera) de Guyane". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/df1d8aa9-6374-4597-9fc1-ab9633094cff">https://bionomia.net/dataset/df1d8aa9-6374-4597-9fc1-ab9633094cff</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/df1d8aa9-6374-4597-9fc1-ab9633094cff">https://gbif.org/dataset/df1d8aa9-6374-4597-9fc1-ab9633094cff</a>. Formatted as a Frictionless Data package
Kulturális adatelemzés – bevezetés és önéletrajz
No full textLev Manovich. Cultural analytics. Cambridge, Massachussetts–London, England: The MIT Press, 2020.https://doi.org/10.7551/mitpress/11214.001.0001. 318 oldal. ISBN 9780262037105, e-ISBN 9780262360647</jats:p
QA catalogue Release v0.5.0
No full textThere are two main things in this release: the British Library and KBR, the national library of Belgium started to use this tool, and both of them and Gent University Library sent important feedback, bug report and feature requests the underlying Java version has been changed to Java 11, and several other technical changes has been implemented In the future we will issue releases more frequently. The list of important changes: #94 Change to Java 11 #89 Check definitins against MARC updates Update No. 24 (May 2017) Update No. 25 (December 2017) Update No. 26 (April 2018) Update No. 27 (November 2018) Update No. 28 (May 2019) Update No. 29 (November 2019) Update No. 30 (May 2020) Update No. 31 (December 2020) Catalogue versions #124 KBR MARC version #99 B3Kat version #95 MARC21NO version #75 British Library version Avram schema files related developments #127 Include version specific subfields to the JSON schema representation and completeness #109 Add solr fields of control fields into the JSON schema #118 Provide alternative Avram versions, and make them transparently available Completeness #106 include indicators #86 display indicators #83 include control fields #81 use IDs for package info #80 count package by doctype #79 create a reusable FieldInfo class for completeness #78 Add package other/unknwon to the package statistics General parameters #105 Add defaultEncoding parameter #101 Read gzipped MARC files #100 Creating a replacement for # in control field from Alma output #126 Skip records without errors from issue-details.csv #125 ignorableFields should not be mentioned in undefined fields #116 Create an INSTALL.md file with installation instructions #113 Reading MARCMaker format #107 Reorganize scripts directory. Right now there is a <code>catalogue</code> directory for the catalogue specific configuration files, and a <code>scripts</code> directory with some subdirectories for the analyse
Abstract 4597: MAPK-mediated gene expression in ER-negative breast cancer: Role of miRNAs and Ago2
No full textAbstract
Background: We have previously shown that the ERα-negative phenotype in breast cancer can be driven by hyperactive MAPK signaling resulting from up-regulation of ErbB family members. We generated a hyperactive MAPK gene signature that is indicative of ERα negativity, contains many genes related to invasion, motility, metastasis, and EMT, and that shows inverse regulation of many genes known to be estrogen dependent. Recent studies have identified differential micro-RNA (miRNA) expression and activity between ERα+ and ERα- breast tumors, implying that miRNAs and their protein targets may play critical roles in both the development and maintenance of these breast cancers. Argonaute-2 (Ago2, EIF2C2), a member of the Argonaute family of proteins, associates with other proteins and miRNAs to form the RNA Induced Silencing Complex (RISC). It is also known that MAPK signaling enhances the expression and stability of Ago2, and in the absence of MAPK signaling Ago2 levels are depleted.
Objective: In this study, we sought to confirm the role of MAPK signaling in Ago2 expression and stability, to determine the role of miRNAs in MAPK mediated down-regulation of ERα expression, to identify MAPK-regulated miRNAs and miRNAs whose activity is mediated through Ago2, and to investigate the roles of these miRNAs in the expression of genes in the hyperactive MAPK gene signature.
Results: Inhibiting MAPK signaling in our hyperactive MAPK cell lines using the MEK inhibitor U0126 resulted in significantly decreased Ago2 expression. Conversely, hyperactivation of MAPK signaling significantly increased Ago2 expression. Using an ERα, 3′UTR-luc reporter containing the sequence known to be targeted by several miRNAs upregulated in ERα- vs ERα+ breast cancer, we determined that hyperactive MAPK drives miRNA targeting of ERα. We then generated an miRNA profile associated with hyperactive MAPK. Notably among the miRNAs whose expression is increased by MAPK are miRNA 221/222, which have been previously shown to be upregulated in ERα- breast cancer and target ERα directly. Using our MAPK gene signature, we determined the miRNAs predicted to regulate those genes, and the activities of these miRNAs in the presence and absence of hyperactive MAPK signaling. Similarly, we are establishing the subset of miRNAs whose activity is altered upon siRNA knockdown of Ago2, indicating that their activities are mediated specifically through Ago2, and then correlating these miRNAs with those predicted to target the MAPK gene signature.
Conclusions: Hyperactive MAPK signaling is directly involved in the generation and maintenance of the ERα negative phenotype. We have shown that specific miRNAs play an important role in this biological process. Ultimately, we will determine if Ago2 plays an important role as a direct mediator of signal transduction events and global gene expression through its integral role in the biological activity of these specific miRNAs.
Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4597.</jats:p
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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