1,726,581 research outputs found
Oncogenic microRNA-4534 regulates PTEN pathway in prostate cancer
Get PDFProstate carcinogenesis involves alterations in several signaling pathways, the most prominent being the PI3K/AKT pathway. This pathway is constitutively active and drives prostate cancer (PCa) progression to advanced metastatic disease. PTEN, a critical tumor and metastasis suppressor gene negatively regulates cell survival, proliferation, migration and angiogenesis via the PI3K/Akt pathway. PTEN is mutated, downregulated/dysfunctional in many cancers and its dysregulation correlates with poor prognosis in PCa. Here, we demonstrate that microRNA-4534 (miR-4534) is overexpressed in PCa and show that miR-4534 is hypermethylated in normal tissues and cell lines compared to PCa tissues/cells. miR-4534 exerts its oncogenic effects partly by downregulating the tumor suppressor PTEN gene. Knockdown of miR-4534 impaired cell proliferation, migration/invasion and induced G0/G1 cell cycle arrest and apoptosis in PCa. Suppression of miR-4534 and its effects on tumor growth was confirmed in a xenograft mouse model. We performed parallel experiments in non-cancer RWPE1 cells by overexpessing miR-4534 followed by functional assays. Overexpression of miR-4534 induced pro-cancerous characteristics in this non-cancer cell line. Statistical analyses revealed that miR-4534 has potential to independently distinguish malignant from normal tissues and positively correlated with poor overall and PSA recurrence free survival. Taken together, our results show that depletion of miR-4534 in PCa induces a tumor suppressor phenotype partly through induction of PTEN. These results have important implications for identifying and defining the role of new PTEN regulators such as microRNAs in prostate tumorigenesis. Understanding aberrantly overexpressed miR-4534 and its downregulation of PTEN will provide mechanistic insight and therapeutic targets for PCa therapy
Block Card 4534 Eddington Court
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Garrison Colonial Style | 4534 Eddington Court (Toledo, Ohio) | Dwelling | Corey Woods Addition (Toledo, Ohio) | Westgate Area (Toledo, Ohio
Block Card 4534 Granville Court
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Garrison Colonial Style | 4534 Granville Court (Toledo, Ohio) | Dwelling | Corey Woods Addition (Toledo, Ohio) | Westgate Area (Toledo, Ohio
Block Card 4534 Penridge Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Cape Cod Style | 4534 Penridge Road (Toledo, Ohio) | Dwelling | Corey Woods Addition (Toledo, Ohio) | Westgate Area (Toledo, Ohio
Block Card 4534 Wedgewood Court
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 4534 Wedgewood Court (Toledo, Ohio) | Dwelling | Corey Woods Addition (Toledo, Ohio) | Westgate Area (Toledo, Ohio
Block Card 4534 East Oakridge Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | Dwelling | 4534 East Oakridge Avenue (Toledo, Ohio) | Forest Grove Addition (Toledo, Ohio) | Trilby Area (Toledo, Ohio)) | West Toledo Area (Toledo, Ohio
4534. Origines lorraines ou champenoises de Jeanne d'Arc
No full text4534. Origines lorraines ou champenoises de Jeanne d'Arc. In: Molinier Auguste. Les Sources de l'histoire de France - Des origines aux guerres d'Italie (1494). IV. Les Valois, 1328-1461. Paris : A. Picard et fils, 1904. p. 329
Linked collectors and determiners for: Correctly mating: on the actual female of Hibana talmina Brescovit and the description of H. labonita sp. n. (Araneae, Anyphaenidae).
No full textNatural history specimen data linked to collectors and determiners held within, "Correctly mating: on the actual female of Hibana talmina Brescovit and the description of H. labonita sp. n. (Araneae, Anyphaenidae)". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/78c81fd2-99ee-4534-9776-40969214c3ce">https://bionomia.net/dataset/78c81fd2-99ee-4534-9776-40969214c3ce</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/78c81fd2-99ee-4534-9776-40969214c3ce">https://gbif.org/dataset/78c81fd2-99ee-4534-9776-40969214c3ce</a>. Formatted as a Frictionless Data package
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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