1,783,509 research outputs found
miR-451-Supplemental.pdf
No full textSupplemental data set for the paper which is showing the involvement of mir-451 in asthmatic inflammatio
Parameters used in the miR-451-AMPK-mTOR model.
No full textParameters used in the miR-451-AMPK-mTOR model.</p
Proposed models of the miR-451-AMPK-mTOR-cell cycle signaling pathway.
No full text(A) Proposed role of miR-451 in the regulation of LKB1/AMPK-mTOR signaling in response to high and low glucose levels. miR-451 levels determine glioma cell migration or proliferation in response to glucose (triangle on the left) via the AMPK-mTOR network [1]. Glucose withdrawal reduces miR-451 levels, resulting in up-regulation of AMPK activity and down-regulation of mTOR. This leads to reduced cell proliferation and enhanced cell motility. Normal glucose levels up-regulate miR-451, which leads to down-regulation of AMPK activity. In turn, down-regulated AMPK levels induce up-regulation of mTOR, which leads to increased proliferation and decreased cell migration. (B) Schematic components of miR-451, CAB39/LKB1/AMPK complex, and mTOR are represented by modules ‘M’ (dotted box on the left), ‘A’ (box with solid line in the middle), and ‘R’ (dotted box on the right), respectively, in our theoretical framework. (C) Detailed schematic of cellular decision of cell proliferation and migration in glioblastoma via signaling networks including miR-451, AMPK, mTOR, and players in the cell cycle module (CycB, Cdh1, p55cdcT, p55cdcA, Plk1) [22].</p
Participant 451 Community Conversations Interview
No full textIn this interview, Participant 451 shares that the biggest change in their life since the pandemic was the switch to remote learning. The participant also discusses challenges with not seeing family members who live in another state. The participant shares that one of their fears is that the pandemic will get worse instead of better. They share that they have been volunteering at a COVID-19 vaccine mega-site, and found that may people might not be knowledgeable about the vaccine.New Jersey Department of Healt
A Fahrenheit 451 című irodalmi mű és filmes adaptációjának elemzése
No full textA mai modern világban már számos bestseller könyvnek van filmes adaptációja. Gondoljunk csak a széles körben kedvelt J. K. Rowling által megalkotott Harry Potter-világra és annak szintén népszerűvé vált filmes feldolgozására. Ezen adaptációk révén sokszor felmerülhet bennünk az a kérdés, hogy melyiket preferáljuk jobban: a könyvet vagy a filmet. Előfordulhat, hogy vannak, akik a Harry Potter könyves változatát kedvelik, de vannak, akik számára csak a film tudta megteremteni a mára már jól ismert és közkedvelt varázslók világát. Ennek egyik oka, hogy másképp ábrázol az írott irodalmi nyelv, és másképp a filmnyelv. Vajon a könyvek és filmek világa közelebb hozható-e egymáshoz? Kiegészítik egymást vagy éppen ennek az ellentéte történik? A későbbiekben részletesebben is tárgyalom, hogy ez a kérdés a filmtörténet kezdeteihez nyúlik vissza és nem pedig kortárs jelenség. Dolgozatom központi témája pedig a Ray Bradbury által írt Fahrenheit 451 című mű és annak filmes adaptációja.Manyar nyelv és irodalom - történelem és állampolgári ismeretek tanáraegységes, osztatla
microRNA-451 protects neurons against ischemia/reperfusion injury-induced cell death by targeting CELF2
No full textQian Liu,1 Yaguang Hu,2 Min Zhang,3 Yousheng Yan,4 Hongmei Yu,1 Li Ge1 1Department of Neurological Rehabilitation, Gansu Provincial Hospital, Gansu 730000, China; 2Department of Pharmacy, Gansu Provincial Maternity and Child-Care Hospital, Gansu 730050, China; 3Department of Pathology, Gansu Provincial Hospital, Gansu 730000, China; 4National Centre for Human Genetic Resources, National Research Institute for Health and Family Planning, Beijing 100089, China Objectives: miRNAs are a family of non-coding RNAs that affect cell growth, migration and apoptosis. However, little is known on the behavior of miRNAs in neurons. Hence, this work aimed to investigate the functions and roles of miRNA-451 in neurons induced by ischemia/reperfusion injury.Materials and methods: In this study, we established a 12- or 24-hour oxygen and glucose deprivation/reoxygenation (OGD/R) cell model. miR-451 mimic, si-CUGBP Elav-like family member 2 (siCELF2), oeCELF2 and the corresponding negative controls were transfected into the 24-hour OGD/R cells. The transfection efficiency and the relative expression of miR-451 and CELF2 were measured using quantitative reverse transcription PCR and Western blot analysis. Cell viability, apoptosis, oxidative stress and cleaved-caspase-3 expression were assessed using Cell Counting Kit-8, LDH, SOD, malondialdehyde, ROS assays, flow cytometry and Western blot analysis upon miR-451 overexpression, CELF2 silencing or overexpression of both. Bioinformatics analysis and the dual-luciferase reporter assay were used to examine the relationship between CELF2 and miR-451 in the OGD/R cells.Results: The results showed that miR-451 was downregulated in the OGD/R cells. The overexpression of miR-451 increased cell viability and SOD activity, but decreased apoptosis rate, levels of LDH, MDA, ROS and cleaved caspase-3 expression. CELF2 silencing inhibited apoptosis and oxidative stress. The results suggested that CELF2 was a target of miR-451, and that CELF2 overexpression alleviated the inhibitory effect of miR-451 on apoptosis and oxidative stress of the OGD/R cells.Conclusion: The results demonstrated that miR-451 could protect cells against OGD/R-induced apoptosis and oxidative stress by targeting CELF2. Keywords: miR-451, CELF2, I/R injury, neuron, oxidative stress, apoptosi
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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