1,727,371 research outputs found
Antisense noncoding mitochondrial RNA-2 gives rise to miR-4485-3p by Dicer processing in vitro
No full textAbstract Background The antisense noncoding mitochondrial RNAs (ASncmtRNAs) derive from the mitochondrial 16S gene. Knockdown of these transcripts with chemically-modified antisense oligonucleotides induces proliferative arrest, apoptosis and invasiveness reduction in tumor but not normal cells. One of these transcripts, ASncmtRNA-2, contains the complete and identical sequence of hsa-miR-4485-3p and, upon knockdown of this transcript, there is a strong increase in levels of this miRNA, suggesting ASncmtRNA-2 as a source for miR-4485-3p, which is supported by several evidences from our group and others, in the ex vivo setting. Results Here we show that incubation of in vitro-transcribed ASncmtRNA-2 with recombinant Dicer produces RNA fragments corresponding to hsa-miR-4485-3p, showing that Dicer binds to and processes ASncmtRNA-2, strongly supporting the hypothesis that ASncmtRNA-2 acts as a precursor for miR-4485-3p. Conclusion The in vitro results presented here strengthen the hypothesis that miR-4485-3p is derived from ASncmtRNA-2 by Dicer processing. Since miR-4485-3p is classified as a tumor suppressor miRNA, this evidence strengthens the application of ASncmtRNA knockdown for cancer therapy
Linked collectors and determiners for: Revision of the West-Palaearctic species of the tribe Cerioidini (Diptera, Syrphidae).
No full textNatural history specimen data linked to collectors and determiners held within, "Revision of the West-Palaearctic species of the tribe Cerioidini (Diptera, Syrphidae)". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/791720e1-fd69-4485-b49c-5b377412ecf1">https://bionomia.net/dataset/791720e1-fd69-4485-b49c-5b377412ecf1</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/791720e1-fd69-4485-b49c-5b377412ecf1">https://gbif.org/dataset/791720e1-fd69-4485-b49c-5b377412ecf1</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: Field Museum of Natural History (Botany) Pteridophyte Collection.
No full textNatural history specimen data linked to collectors and determiners held within, "Field Museum of Natural History (Botany) Pteridophyte Collection". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/9f747cff-839f-4485-83a1-f10317a92a82">https://bionomia.net/dataset/9f747cff-839f-4485-83a1-f10317a92a82</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/9f747cff-839f-4485-83a1-f10317a92a82">https://gbif.org/dataset/9f747cff-839f-4485-83a1-f10317a92a82</a>. Formatted as a Frictionless Data package
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Linked collectors and determiners for: Revision of the West-Palaearctic species of the tribe Cerioidini (Diptera, Syrphidae).
No full textNatural history specimen data linked to collectors and determiners held within, "Revision of the West-Palaearctic species of the tribe Cerioidini (Diptera, Syrphidae)". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/791720e1-fd69-4485-b49c-5b377412ecf1">https://bionomia.net/dataset/791720e1-fd69-4485-b49c-5b377412ecf1</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/791720e1-fd69-4485-b49c-5b377412ecf1">https://gbif.org/dataset/791720e1-fd69-4485-b49c-5b377412ecf1</a>. Formatted as a Frictionless Data package
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
X-ray and optical properties of ULXs in NGC 4490/4485
No full textTurkish Physical Society 33rd International Physics Congress, TPS 2017 --6 September 2017 through 10 September 2017 -- --The X-ray and optical properties of seven ultraluminous X-ray Sources (ULXs) in the interacting galaxies NGC 4490/4485 were examined in this study. The XMM-Newton and Chandra archival data were used for X-ray analyses. To study the optical counterparts of ULXs, the Hubble Space Telescope, (HST) archival data were used. After the relative astrometric correction between the Chandra and HST images, bright optical counterpart candidates were found for three ULXs (X-4, X-6 and X-7). © 2018 Author(s)
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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