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Single nucleotide polymorphism rs13079080 is associated with differential regulation of the succinate receptor 1 (SUCNR1) gene by miRNA-4470
No full textOxidative stress is a feature of many common diseases. It leads to excessive formation and subsequent release of the mitochondrial metabolite succinate, which acts as a signalling molecule through binding the succinate receptor (SUCNR1). Recently, a potential role for SUCNR1 was proposed in age-related macular degeneration (AMD), a common cause of vision loss in the elderly associated with increased oxidative stress. Here, we evaluated the potential effect of genetic variants in SUCNR1 on its expression through differential micro-RNA (miRNA) binding to target mRNA, and investigated the relevance of altered SUCNR1 expression in AMD pathogenesis. We analysed common SUCNR1 SNPs for potential miRNA binding sites and identified rs13079080, located in the 3ʹ-UTR and binding site for miRNA-4470. Both miRNA-4470 and SUCNR1 were found to be expressed in human retina. Moreover, using a luciferase reporter assay, a 60% decrease in activity was observed when miRNA-4470 was co-expressed with the C allele compared to the T allele of rs13079080. Finally, genotyping rs13079080 in an AMD case-control cohort revealed a protective effect of the TT genotype on AMD compared to the CC genotype (p = 0.007, odds ratio = 0.66). However, the association was not confirmed in the case-control study of the International AMD Genomics Consortium. Our study demonstrates that the T allele of rs13079080 in SUCNR1 disrupts a binding site for miRNA-4470, potentially increasing SUCNR1 expression and consequently increasing the capacity of sensing and dealing with oxidative stress. Therefore, it would be worthwhile assessing the relevance of rs13079080 in other oxidative stress-associated diseases in future studies.</p
Mcmillan, Daniel, 4470
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/404176Surname: MCMILLAN. Given Name(s) or Initials: DANIEL. Military Service Number or Last Known Location: 4470. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 33346.240423
Item: [2016.0049.36468] "Mcmillan, Daniel, 4470
A 4470-Point Scrabble Game
Get PDFIn the February 1981 issue of Word Ways we exhibited a theoretical solitaire Scrabble game where all 100 titles are used to achieve a score of 4454 points. With some slight adjustments to the setup and a few new words it is possible to add 16 more points, giving a new total of 4470. Asterisks (*) indicate the two blank tiles
[Veto of H. 4470, R-385]
No full textThis veto message from Governor Mark Sanford vetoes H. 4470, R-385 a bill that gives local governments the option of providing a property tax credit to property owners who install fire sprinklers equal to 25 percent of the cost of installation
Linked collectors and determiners for: Description of the first species of Glomeridesmida from Thailand (Diplopoda, Glomeridesmida, Glomeridesmidae).
No full textNatural history specimen data linked to collectors and determiners held within, "Description of the first species of Glomeridesmida from Thailand (Diplopoda, Glomeridesmida, Glomeridesmidae)". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/c542e28a-4470-4cd2-a945-a24f723f5253">https://bionomia.net/dataset/c542e28a-4470-4cd2-a945-a24f723f5253</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/c542e28a-4470-4cd2-a945-a24f723f5253">https://gbif.org/dataset/c542e28a-4470-4cd2-a945-a24f723f5253</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: On the taxonomy of Afrotropical Coleophoridae (IV). New or little known species from South Africa (Lepidoptera, Coleophoridae).
No full textNatural history specimen data linked to collectors and determiners held within, "On the taxonomy of Afrotropical Coleophoridae (IV). New or little known species from South Africa (Lepidoptera, Coleophoridae)". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/c35077ff-461c-4470-9158-8c096a1b45e0">https://bionomia.net/dataset/c35077ff-461c-4470-9158-8c096a1b45e0</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/c35077ff-461c-4470-9158-8c096a1b45e0">https://gbif.org/dataset/c35077ff-461c-4470-9158-8c096a1b45e0</a>. Formatted as a Frictionless Data package
The influence of culture conditions and serum lipids on interleukin-1 production by human monocytes
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4470.pdf (Publisher’s version ) (Open Access
Linked collectors and determiners for: BioGIS - Bryophytes - HUJ collections.
No full textNatural history specimen data linked to collectors and determiners held within, "BioGIS - Bryophytes - HUJ collections". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/0bf5686d-46dc-4470-8e3e-00904eb15e1e">https://bionomia.net/dataset/0bf5686d-46dc-4470-8e3e-00904eb15e1e</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/0bf5686d-46dc-4470-8e3e-00904eb15e1e">https://gbif.org/dataset/0bf5686d-46dc-4470-8e3e-00904eb15e1e</a>. Formatted as a Frictionless Data package
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