1,724,512 research outputs found
Lowe, Mr William And Mrs Elah, 4408
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/400151Surname: LOWE. Given Name(s) or Initials: MR WILLIAM AND MRS ELAH. Military Service Number or Last Known Location: 4408. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 47609.218422
Item: [2016.0049.32444] "Lowe, Mr William And Mrs Elah, 4408
Block Card 4408 East Way
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling (Toledo, Ohio) | Colonial Revival Style | Homeville Subdivision (Toledo, Ohio) | Willys Park area (Toledo, Ohio) | West Toledo (Toledo, Ohio) | 4408 East Way (Toledo, Ohio
Block Card 4408 Foxglove Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | Dwelling | Harvest Lane Home Sites (Toledo, Ohio) | Franklin Park Area (Toledo, Ohio) | Trilby Area (Toledo, Ohio)) | 4408 Foxglove Road (Toledo, Ohio
Abstract 4408: A functional genomics approach for identification of sirolimus sensitizer genes regulated by HDAC inhibitors.
No full textAbstract
The molecular pathogenesis of many cancer types, including multiple myeloma (MM), involves alterations in the PI3K/Akt/mTOR and cyclin/CDK/CDKI/Rb (Rb) pathways. We have shown the combination of a Class I-specific HDAC inhibitor (entinostat, MS-275) with the mTOR inhibitor sirolimus to be synergistic in a large panel of B cell tumor cell lines including multiple myeloma, mantle cell and Burkitt's lymphoma. While tumor outgrowth occurred in both single agent arms, the combination effectively controlled in vivo tumor growth in long-term preclinical studies. The combination was also highly effective in a tumor-cell specific bioluminescence assay where myeloma cells are co-cultured with bone marrow stromal cells to mimic the protective effects of the tumor microenvironment. We found the combination antagonized the oncogenic activation of the AKT pathway associated with single-agent rapamycin treatment, inhibited the ERK/MAPK pathway, decreased pro-survival signaling, and increased growth inhibitory signals to a much greater extent than either single agent alone. To further understand the molecular mechanisms contributing to the synergy of this combination, a functional genomics approach utilizing high-throughput RNAi screening and gene expression profiling was taken. Several cell cycle-specific kinases were identified that upon inhibition enhance the activity of sirolimus and are significantly down-regulated by entinostat. Thus far, we have confirmed by western blot that PLK1 and AURKB are decreased in a dose-dependent manner by entinostat. Specific inhibition of these targets synergizes with sirolimus. Additionally, we found very low (<EC20) entinostat/sirolimus combination doses to hyper-sensitize tumor cells to a number of cell cycle inhibitors. These findings are further supported by increased cell cycle arrest seen in the combination treatment compared to either drug alone, as well as marked reduction in the cell cycle progression marker phospho-Histone H3. Taken together, our findings indicate the anti-tumor synergy of combined HDAC/mTOR inhibition is the result of multiple cooperative effects.
Citation Format: Benjamin J. Gamache, John Simmons, Jyoti Patel, Lihui Ou, Aleksandra Michalowski, Patrick Sullivan, Bih-Rong Wei, R. Mark Simpson, Shuling Zhang, Ke Zhang, W. Michael Kuehl, Ola Landgren, Natasha Caplen, Beverly Mock. A functional genomics approach for identification of sirolimus sensitizer genes regulated by HDAC inhibitors. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4408. doi:10.1158/1538-7445.AM2013-440
Photograph of Exterior Mural on Bldg. 4408
No full textPhotograph of mural on Bldg. 4408, Col. Durham Street between 6th Avenue and Parker Flats cut-off, south exterior wall, 48.75 wide x 224 high. 67th Ordnance Battalion. Motto on mural Strength Through Support. Unit was originally referred to as Mechanical Repair Shop No. 305 when it was organized at Fort Bliss Texas in October 1917.https://digitalcommons.csumb.edu/fortord_images/1066/thumbnail.jp
Linked collectors and determiners for: Moniliophyta del Herbario BAB (Instituto de Recursos Biológicos CIRN-INTA).
No full textNatural history specimen data linked to collectors and determiners held within, "Moniliophyta del Herbario BAB (Instituto de Recursos Biológicos CIRN-INTA)". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/4c992c6f-4a3f-4408-9fa1-1d01ef49fa1d">https://bionomia.net/dataset/4c992c6f-4a3f-4408-9fa1-1d01ef49fa1d</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/4c992c6f-4a3f-4408-9fa1-1d01ef49fa1d">https://gbif.org/dataset/4c992c6f-4a3f-4408-9fa1-1d01ef49fa1d</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: A monograph of the genus Maladera Mulsant & Rey, 1871 of China (Coleoptera: Scarabaeidae: Melolonthinae: Sericini).
No full textNatural history specimen data linked to collectors and determiners held within, "A monograph of the genus Maladera Mulsant & Rey, 1871 of China (Coleoptera: Scarabaeidae: Melolonthinae: Sericini)". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/188411de-569c-4408-a016-1a04b858c142">https://bionomia.net/dataset/188411de-569c-4408-a016-1a04b858c142</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/188411de-569c-4408-a016-1a04b858c142">https://gbif.org/dataset/188411de-569c-4408-a016-1a04b858c142</a>. Formatted as a Frictionless Data package
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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