1,725,133 research outputs found
Efficient, Protecting Group Free Kilogram-Scale Synthesis of the JAK1 Inhibitor GDC-4379
No full textThe development of an improved kilogram-scale
synthesis of the
JAK1 inhibitor GDC-4379 for the treatment of asthma is
described. The new process is highlighted by a step-economical construction
of a 3-substituted-4-aminopyrazole employing a telescoped oximation
and hydrazine condensation of a 1,3-dielectrophile to generate nitrosopyrazole
and a novel copper-catalyzed NaBH4 reduction of the nitroso
group. The endgame process features an amidation of aminopyrazole
with acid chloride under Schotten–Baumann conditions to provide
access to the penultimate intermediate. A selective N-1 alkylation
of the pyrazole moiety was accomplished under phase-transfer conditions,
which delivered GDC-4379 with a defined particle-size
distribution suitable for micronization after recrystallization and
wet milling
4379. Campagne de Normandie et victoire de Formigny
No full text4379. Campagne de Normandie et victoire de Formigny. In: Molinier Auguste. Les Sources de l'histoire de France - Des origines aux guerres d'Italie (1494). IV. Les Valois, 1328-1461. Paris : A. Picard et fils, 1904. pp. 296-297
4379. Campagne de Normandie et victoire de Formigny
No full text4379. Campagne de Normandie et victoire de Formigny. In: Molinier Auguste. Les Sources de l'histoire de France - Des origines aux guerres d'Italie (1494). IV. Les Valois, 1328-1461. Paris : A. Picard et fils, 1904. pp. 296-297
Linked collectors and determiners for: Synonymy of Reikosiella Yoshimoto under Merostenus Walker (Hymenoptera: Chalcidoidea: Eupelmidae), with a checklist of world species and a revision of those species with brachypterous females.
No full textNatural history specimen data linked to collectors and determiners held within, "Synonymy of Reikosiella Yoshimoto under Merostenus Walker (Hymenoptera: Chalcidoidea: Eupelmidae), with a checklist of world species and a revision of those species with brachypterous females". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/4a65facc-ae9e-4379-a86f-0d8d34f58096">https://bionomia.net/dataset/4a65facc-ae9e-4379-a86f-0d8d34f58096</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/4a65facc-ae9e-4379-a86f-0d8d34f58096">https://gbif.org/dataset/4a65facc-ae9e-4379-a86f-0d8d34f58096</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: Apoyo a las colecciones biológicas de la Facultad de Ciencias de la UNAM: Fase 1 (Herpetológica).
No full textNatural history specimen data linked to collectors and determiners held within, "Apoyo a las colecciones biológicas de la Facultad de Ciencias de la UNAM: Fase 1 (Herpetológica)". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/749dd468-22d4-4379-893d-352606a6f2d7">https://bionomia.net/dataset/749dd468-22d4-4379-893d-352606a6f2d7</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/749dd468-22d4-4379-893d-352606a6f2d7">https://gbif.org/dataset/749dd468-22d4-4379-893d-352606a6f2d7</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: Alabama Museum of Natural History Paleontology specimens (Arctos).
No full textNatural history specimen data linked to collectors and determiners held within, "Alabama Museum of Natural History Paleontology specimens (Arctos)". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/c8ba2098-74e5-4379-82dc-e83804b59e3f">https://bionomia.net/dataset/c8ba2098-74e5-4379-82dc-e83804b59e3f</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/c8ba2098-74e5-4379-82dc-e83804b59e3f">https://gbif.org/dataset/c8ba2098-74e5-4379-82dc-e83804b59e3f</a>. Formatted as a Frictionless Data package
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Linked collectors and determiners for: USAC, CECON, Herbario USCG.
No full textNatural history specimen data linked to collectors and determiners held within, "USAC, CECON, Herbario USCG". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/d5ba665a-c07b-4379-85ff-15d7e3a9331a">https://bionomia.net/dataset/d5ba665a-c07b-4379-85ff-15d7e3a9331a</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/d5ba665a-c07b-4379-85ff-15d7e3a9331a">https://gbif.org/dataset/d5ba665a-c07b-4379-85ff-15d7e3a9331a</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: Synonymy of Reikosiella Yoshimoto under Merostenus Walker (Hymenoptera: Chalcidoidea: Eupelmidae), with a checklist of world species and a revision of those species with brachypterous females.
No full textNatural history specimen data linked to collectors and determiners held within, "Synonymy of Reikosiella Yoshimoto under Merostenus Walker (Hymenoptera: Chalcidoidea: Eupelmidae), with a checklist of world species and a revision of those species with brachypterous females". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/4a65facc-ae9e-4379-a86f-0d8d34f58096">https://bionomia.net/dataset/4a65facc-ae9e-4379-a86f-0d8d34f58096</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/4a65facc-ae9e-4379-a86f-0d8d34f58096">https://gbif.org/dataset/4a65facc-ae9e-4379-a86f-0d8d34f58096</a>. Formatted as a Frictionless Data package
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