1,724,766 research outputs found
Daly, Augustine Joseph, 4353
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/380385Surname: DALY
Given Name(s) or Initials: AUGUSTINE JOSEPH
Military Service Number or Last Known Location: 4353
Missing, Wounded and Prisoner of War Enquiry Card Index Number: 26662194197
Item: [2016.0049.12678] "Daly, Augustine Joseph, 4353
Abstract 4353: Stroma drive metabolic reprogramming and induces stemness properties in pancreatic cancer cells
No full textAbstract Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most devastating human malignancies with poor survival rate owing to chemoresistance and relapse. Small population of Tumor Initiating Cells (TIC) are considered major players driving these traits. Recent literature has demonstrated the importance of microenvironment “niche” in enrichment of these TIC populations. The desmoplastic stroma in pancreatic cancer comprising of stromal cells and immune cells are instrumental in pathogenesis and progression of PDAC. Among many cytokines, IL-6 a pro-inflammatory cytokine plays a major role in it. In this study, we show that stromal cell secreted IL6 altered metabolic reprogramming and increased cancer stemness in PDAC cells. PDAC cells cultured with pancreatic stellate cells condition media (PSC-CM) or recombinant IL6 and stem ness markers expression were investigated. Cytometry Bead Array (CBA) were used for cytokine profiling. Metabolic alteration along with TIC gene expression were measured using flow cytometry and Seahorse. PDAC cells when cultured with PSC-CM exhibited increase glucose uptake along with an enrichment of CD133+ population. An analysis of the conditioned media using CBA reveled that PSC-CM is enriched with cytokine IL-6 and TNF-α. Treatment of PDAC cells with recombinant IL-6 increased expression of self-renewal genes SOX2, OCT4, Nanog along with biochemical marker ALDH. In addition, TIC marker CD133 and invasion marker gene MMP7 expression also increased upon IL6 induction. Moreover, IL6 treatment increased glucose uptake and lactate secretion. Small molecule inhibitor Stattic (inhibitor of STAT3) inhibit glucose uptake and stemness gene expression.Our study shows that stromal IL6 altered metabolic reprogramming in cancer cells as well as increased cancer stemness and invasion. In future, the underlying mechanisms of IL-6 driven metabolic alteration and its impact on stemness and metastasis will be investigated. Citation Format: Kousik K. Kesh, Vineet K. Gupta, Nikita Sharma, Roey Hadad, Vikas Dudeja, Ashok Saluja, Sulagna Banerjee. Stroma drive metabolic reprogramming and induces stemness properties in pancreatic cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4353
Block Card 4353 East Way
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling (Toledo, Ohio) | Colonial Revival Style | Homeville Subdivision (Toledo, Ohio) | Willys Park area (Toledo, Ohio) | West Toledo (Toledo, Ohio) | 4353 East Way (Toledo, Ohio
Block Card 4353 Rose Garden Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: dwelling | 4353 Rose Garden Drive (Toledo, Ohio) | Split-Level Style | Nopper Garden Estates Plat 2 | Franklin Park Area (Toledo, Ohio) | West Toledo (Toledo, Ohio
Southern Pacific (SP) 4353 & 4437 on "San Joaquin Daylight"
No full textA photograph postcard showing the Southern Pacific (SP) 4353 (4-8-2) & 4437 (4-8-4), on passenger train No. 51, "San Joaquin Daylight", near Lang, CA, 14 cars, 30 mph
Linked collectors and determiners for: Diversidad de Hemiptera: Heteroptera de Baja California e islas del Golfo de California.
No full textNatural history specimen data linked to collectors and determiners held within, "Diversidad de Hemiptera: Heteroptera de Baja California e islas del Golfo de California". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/08a2981f-1e9e-4353-8599-65c448bac864">https://bionomia.net/dataset/08a2981f-1e9e-4353-8599-65c448bac864</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/08a2981f-1e9e-4353-8599-65c448bac864">https://gbif.org/dataset/08a2981f-1e9e-4353-8599-65c448bac864</a>. Formatted as a Frictionless Data package
Southern Pacific (SP) 4353 & 4352 on "San Joaquin Daylight"
No full textA photograph postcard showing the Southern Pacific (SP) 4353 (4-8-2) & 4352 (4-8-2), on passenger train No. 52, "San Joaquin Daylight", easttbound on the Tehachapi Loop near Bakersfield, CA
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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