1,726,493 research outputs found
Long non-coding RNAs PGM5-AS1 upregulates Decorin (DCN) to inhibit cervical cancer progression by sponging miR-4284
No full textLong non-coding RNAs (lncRNAs) have been widely studied and play crucial roles in cervical cancer (CC) progression. Here, we investigated the function and mechanism of lncRNA PGM5-AS1 action in CC cells. Using real-time quantitative polymerase chain reaction or western blotting, PGM5-AS1 and decorin (DCN) were downregulated in CC tissues and cells, whereas miR-4284 was upregulated. Luciferase assay, RNA pull-down assay, and western blotting showed that PGM5-AS1 could sponge miR-4284 to upregulate DCN expression in CC cells. Additionally, cell functional experiments showed that PGM5-AS1 overexpression led to decreased proliferation, migration, and invasion of CC cells. However, the inhibitory effect of PGM5-AS1 overexpression on CC cells was partly relieved by DCN knockdown because of the targeting interaction between PGM5-AS1, miR-4284, and DCN. In summary, this study identified that PGM5-AS1 negatively regulates CC cell malignancy by targeting miR-4284/DCN.</p
Linked collectors and determiners for: UWIZM Scarabaeidae Beetles.
No full textNatural history specimen data linked to collectors and determiners held within, "UWIZM Scarabaeidae Beetles". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/643006ae-90d9-4284-8ed6-499e75fba0c8">https://bionomia.net/dataset/643006ae-90d9-4284-8ed6-499e75fba0c8</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/643006ae-90d9-4284-8ed6-499e75fba0c8">https://gbif.org/dataset/643006ae-90d9-4284-8ed6-499e75fba0c8</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: Odonata de Veracruz.
No full textNatural history specimen data linked to collectors and determiners held within, "Odonata de Veracruz". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/ac62357d-eaf9-4284-9720-7d327f5f5c99">https://bionomia.net/dataset/ac62357d-eaf9-4284-9720-7d327f5f5c99</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/ac62357d-eaf9-4284-9720-7d327f5f5c99">https://gbif.org/dataset/ac62357d-eaf9-4284-9720-7d327f5f5c99</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: UWIZM Scarabaeidae Beetles.
No full textNatural history specimen data linked to collectors and determiners held within, "UWIZM Scarabaeidae Beetles". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/643006ae-90d9-4284-8ed6-499e75fba0c8">https://bionomia.net/dataset/643006ae-90d9-4284-8ed6-499e75fba0c8</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/643006ae-90d9-4284-8ed6-499e75fba0c8">https://gbif.org/dataset/643006ae-90d9-4284-8ed6-499e75fba0c8</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: KwaZulu-Natal Museum-Arachnida-Collection.
No full textNatural history specimen data linked to collectors and determiners held within, "KwaZulu-Natal Museum-Arachnida-Collection". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/d90727f8-cb15-4284-8197-1d43f80bcec6">https://bionomia.net/dataset/d90727f8-cb15-4284-8197-1d43f80bcec6</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/d90727f8-cb15-4284-8197-1d43f80bcec6">https://gbif.org/dataset/d90727f8-cb15-4284-8197-1d43f80bcec6</a>. Formatted as a Frictionless Data package
Long non-coding RNAs PGM5-AS1 upregulates Decorin (DCN) to inhibit cervical cancer progression by sponging miR-4284
Get PDFLong non-coding RNAs (lncRNAs) have been widely studied and play crucial roles in cervical cancer (CC) progression. Here, we investigated the function and mechanism of lncRNA PGM5-AS1 action in CC cells. Using real-time quantitative polymerase chain reaction or western blotting, PGM5-AS1 and decorin (DCN) were downregulated in CC tissues and cells, whereas miR-4284 was upregulated. Luciferase assay, RNA pull-down assay, and western blotting showed that PGM5-AS1 could sponge miR-4284 to upregulate DCN expression in CC cells. Additionally, cell functional experiments showed that PGM5-AS1 overexpression led to decreased proliferation, migration, and invasion of CC cells. However, the inhibitory effect of PGM5-AS1 overexpression on CC cells was partly relieved by DCN knockdown because of the targeting interaction between PGM5-AS1, miR-4284, and DCN. In summary, this study identified that PGM5-AS1 negatively regulates CC cell malignancy by targeting miR-4284/DCN
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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