1,724,685 research outputs found
Therapeutic Suppression of miR-4261 Attenuates Colorectal Cancer by Targeting MCC
No full textThe mutated in colorectal cancer (MCC) gene is an important colorectal tumor suppressor gene, although few studies have reported the microRNA(s) that could directly target MCC in colorectal cancer. Here, we used microRNA (miRNA) target prediction algorithms, and previously reported microarray data in human colorectal cancer found that only miR-4261 was predicted by all three databases to directly target MCC. Based on specimens from our own cohort of colorectal cancer patients, we further demonstrated that miR-4261 was overexpressed in colorectal cancer. Interestingly, overexpression of miR-4261 could enhance cell proliferation and G1/S phase transition of cell cycle, and promote cell migration in HCT116 and HT29 cells, while inhibition of miR-4261 had opposite effects. Luciferase reporter assay and western blot analysis confirmed MCC as a direct target of miR-4261. MCC small interfering RNA (siRNA) could abolish the suppressive effects of miR-4261 inhibitor on cell proliferation and migration in HCT116 and HT29 cell lines. Finally, we showed that therapeutic intervention with lentivirus-based miR-4261 sponge injection could effectively reduce tumor growth and inhibit cell proliferation in colorectal cancer xenograft. Collectively, our study is the first one to unravel the functional role of miR-4261, and it provides strong evidence that inhibition of miR-4261 through targeting of MCC might exert a therapeutic effect for colorectal cancer. Keywords: colorectal cancer, miR-4261, MC
Block Card 4261 Glendale Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: 4261 Glendale Avenue (Toledo, Ohio) | Dwelling | South Toledo Area (Toledo, Ohio) | American four and a half squar
Recommended from our members
NGC 4261 and NGC 4697: Rejuvenated Elliptical Galaxies
No full textChandra images present evidence of a nonuniform spatial distribution of discrete X-ray sources in the elliptical galaxy NGC 4261. This nonuniform distribution is inconsistent with the optical morphology of NGC 4261 at greater than a 99.9% confidence level. Similar evidence is seen in one more elliptical galaxy (NGC 4697; 98% confidence level) out of five cases we investigated. NGC 4261 and NGC 4697 have old stellar populations (9-15 Gyr) and fine-structure parameters of 1 and 0, respectively, suggesting that no recent merging activity occurred. On the basis of simulations of galaxy interactions, we propose that the X-ray sources responsible for the nonuniform distribution are associated with young stellar populations, related to the rejuvenating fallback of material in tidal tails onto a relaxed merger remnant or to shock-induced star formation along the tidal tails.Accepted Manuscrip
The radio jets and accretion disk in NGC 4261
Full text linkThe nearby (41 Mpc) FR-I radio galaxy NGC 4261 contains a pair of symmetric kpc-scale jets, emerging from the vicinity of a 5×108 M☉ black hole. We present new VLBA observations of NGC 4261 at 22 and 43 GHz which we combine with previous observations at 1.6 and 8.4 GHz. We find that the orientation of the radio jet axis is the same on pc and kpc scales, indicating that the spin axis of the inner accretion disk and black hole has remained unchanged for at least 106 (and more likely \u3e107) years. This suggests that a single merger event may be responsible for the supply of gas in the nucleus of NGC 4261. We also use our VLBA images to probe the structure of the accretion disk on sub-parsec scales through free-free absorption of synchrotron emission from the base of symmetric radio jets
Linked collectors and determiners for: A monograph of the Afrotropical Cassidinae (Coleoptera: Chrysomelidae). Part 4. Revision of the genus Chiridopsis Spaeth.
No full textNatural history specimen data linked to collectors and determiners held within, "A monograph of the Afrotropical Cassidinae (Coleoptera: Chrysomelidae). Part 4. Revision of the genus Chiridopsis Spaeth". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/508504a4-6365-4261-a0d7-e1a69ed91a85">https://bionomia.net/dataset/508504a4-6365-4261-a0d7-e1a69ed91a85</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/508504a4-6365-4261-a0d7-e1a69ed91a85">https://gbif.org/dataset/508504a4-6365-4261-a0d7-e1a69ed91a85</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: A monograph of the Afrotropical Cassidinae (Coleoptera: Chrysomelidae). Part 4. Revision of the genus Chiridopsis Spaeth.
No full textNatural history specimen data linked to collectors and determiners held within, "A monograph of the Afrotropical Cassidinae (Coleoptera: Chrysomelidae). Part 4. Revision of the genus Chiridopsis Spaeth". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/508504a4-6365-4261-a0d7-e1a69ed91a85">https://bionomia.net/dataset/508504a4-6365-4261-a0d7-e1a69ed91a85</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/508504a4-6365-4261-a0d7-e1a69ed91a85">https://gbif.org/dataset/508504a4-6365-4261-a0d7-e1a69ed91a85</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: Armas Järvelä's Lepidoptera Collection.
No full textNatural history specimen data linked to collectors and determiners held within, "Armas Järvelä's Lepidoptera Collection". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/5303c979-38da-4261-93c5-6297203833f4">https://bionomia.net/dataset/5303c979-38da-4261-93c5-6297203833f4</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/5303c979-38da-4261-93c5-6297203833f4">https://gbif.org/dataset/5303c979-38da-4261-93c5-6297203833f4</a>. Formatted as a Frictionless Data package
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
- …
