1,775,926 research outputs found
Trykk 424
No full text424 med tittel: Disponering av person- og konduktørvogner (unntatt motorvognmateriell
Bulletin No. 424 - Range Survey in Wyoming's Big Horn Basin
No full textBulletin No. 424 - Range Survey in Wyoming's Big Horn Basi
miR-424 targets AKT3 and PSAT1 and has a tumor-suppressive role in human colorectal cancer
No full textYifeng Fang,1 Xiao Liang,1 Junfen Xu,2 Xiujun Cai1 1Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China; 2Department of Gynecologic Oncology, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, China Background: Recent advances in cancer biology have uncovered critical roles for microRNAs in regulating tumor responses. This study is to elucidate the role of miR-424 in colorectal cancer development. Materials and methods: miR-424 expression was analyzed by qRT-PCR. The role of miR-424 was studied in cell lines and animal models. The downstream targets of miR-424 were determined by microarray analysis. Results: We found that miR-424 expression was downregulated in human colorectal cancer cell lines and patient biopsies. We demonstrated that miR-424 functioned as a tumor suppressor by suppressing colorectal cancer growth in vitro and in vivo and enhancing apoptosis. Using microarray screening, we subsequently presented evidence that miR-424 directly targeted the 3′ untranslated regions of the AKT serine/threonine kinase 3 (AKT3) and phosphoserine aminotransferase 1 (PSAT1) mRNAs via luciferase assay. Furthermore, AKT3 or PSAT1 silencing partially recapitulated the effects of miR-424. Conclusion: This newly identified miR-424/AKT3–SAT1 axis may represent a novel therapeutic strategy for future treatment of colorectal cancer. Keywords: miR-424, AKT3, PSAT1, colorectal cance
Hypoxic bone marrow mesenchymal stem cell exosomes promote angiogenesis and enhance endometrial injury repair through the miR-424-5p-mediated DLL4/Notch signaling pathway.
No full textThere are large amounts of data and raw images, including the characterization of BMSC-exo, promotion of cell proliferation and angiogenesis by hypoxic BMSC-exo through miR-424-5p, targeting DLL4 expression by miR-424-5p, promotion of angiogenesis by hypoxic exosomes through miR-424p-mediated DLL5/Notch signaling pathway, promotion of intrauterine adhesion (IUA) angiogenesis by BMSC exosomes, and promotion of IUA angiogenesis through miR-424-5p-mediated DLL4/Notch signaling.</p
<b>The impact of miR-424-5p in bladder cancer</b>
No full textWe focused on miR-424-5p, which was down-regulated in cisplatin-resistant bladder cancer, and found that CCNE1 expression was up-regulated in cisplatin-resistant bladder cancers, and explored therapeutic strategies in CCNE1-highly expressing bladder cancer.</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Journal of the sessions of the House of Representatives 1839
No full textEsta imagen contiene una noticia sobre el debate en torno a las licencias para predicar y confesar. Durante la discusión, Ospina propuso un control más estricto del clero, lo que le valió críticas por no ser considerado un liberal. Esta noticia fue publicada en Quijano 424 en 1839, en las páginas 299 a 304.This image contains a news item about the debate surrounding licenses to preach and confess. During the discussion, Ospina proposed stricter control of the clergy, which earned him criticism for not being considered a liberal. This news item was published in Quijano 424 in 1839, on pages 299 to 304
Sedimentology, mineralogy, and geochemistry of hydrothermal deposits at DSDP Site 54-424
No full textOn Leg 54 of the Deep Sea Drilling Project, four holes were drilled at Site 424, about 20 km south of the Galapagos Spreading Center (GSC). The holes were situated less than 300 meters from each other on a north-south line in water about 2700 meters deep, near 0°35'N and 86°07'W. The age of the basaltic basement here is about 0.60 to 0.62 m.y. (Hekinian et al., 1978). This particular site was chosen because a major sea-floor hydrothermal system, with associated sediments, occurs in this area (Klitgord and Mudie, 1974; Lonsdale, 1977).
The sampling area is characterized by small mounds, 5 to 20 meters high, parallel to the axis of the GSC, and is associated with heat flow (Williams et al., 1974; Crane and Normark, 1977). The mounds are arrayed above faults in the basaltic basement (Lonsdale, 1977). The regional sedimentary blanket is about 30 meters thick. Bottom photographs made of the mounds by Corliss et al. (1978) show that they consist of black crusts with light brown and orange patches and that some are partially covered by organisms (e.g., bivalves). Holes 424 and 424A were located as precisely as possible on two mounds. The sediments are respectively 31 and 34 meters thick. Hole 424B is sampled about 300 meters north of Hole 424 in an area between two mounds. The sedimentary thickness is 38 meters. Finally, Hole 424C, also away from any mounds, was only partially sampled; only 7 meters of sediments in the topmost core was recovered. The sedimentary thickness is 30.5 meters
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