1,725,271 research outputs found
Block Card 4166 Dorchester Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | Dwelling | Mount Vernon Subdivision (Toledo, Ohio) | Inverness Area (Toledo, Ohio) | 4166 Dorchester Road (Toledo, Ohio
A new hypoglycemic agent, A-4166, inhibits ATP-sensitive potassium channels in rat pancreatic beta-cells
No full textEffects of a new hypoglycemic drug, N-[trans-4-isopropylcyclohexy-carbonyl]-D-phenylalanine (A-4166), on membrane current were investigated using the patch-clamp technique in single pancreatic beta-cells isolated from rats. A-4166, at a concentration of 10 microM, depolarized membrane potential of beta-cells and evoked action potentials in the presence of 2.8 mM glucose. The single ATP-sensitive K+ channel (K-ATP channel) current recorded in cell-attached membrane patches was reversibly inhibited by A-4166 (> 0.1 microM) without a change in the single-channel conductance of the K-ATP channel. Both A-4166 and tolbutamide inhibited the whole cell K-ATP channel current with half-maximum inhibition (IC50) of 0.23 and 12.8 microM, respectively (Hill coefficient = 1). In inside-out membrane patches, the IC50 with A-4166 occurred at 4.5 nM, in contrast to 0.7 microM for tolbutamide. A-4166 did not affect L- and T-type Ca2+ channels or the time-dependent outward current. We conclude that A-4166 specifically blocks the K-ATP channel and that the blockade is more potent than that of tolbutamide. The action of A-4166 underlies the mechanism by which the drug stimulates insulin secretion from beta-cells.</jats:p
A lipopolysaccharide-specific bacteriophage for Aeromonas salmonicida
No full textCell wall lipopolysaccharide (LPS) was identified as the receptor for the A. salmonicida bacteriophage strain 55R-1. Mutants of A. salmonicida resistant to phage 55R-1 were unable to adsorb phage 55R-1 and were shown to be defective in LPS structure. Purified A. salmonicida LPS inactivated phage 55R-1, but the O-polysaccharide and the core oligosaccharide portions of the LPS were ineffective. These results suggest that lipid A was required for receptor activity. Antibodies directed against LPS also inhibited phage adsorption..RE: 16 ref.; SC: ZA; CA; VE; 0V; 0ISource type: Electronic(1) http://upei-resolver.asin-risa.ca?sid=SP:CABI&id=pmid:&id=&issn=0008-4166&isbn=&volume=29&issue=10&spage=1458&pages=1458-1461&date=1983&title=Canadian%20Journal%20of%20Microbiology&atitle=A%20lipopolysaccharide-specific%20bacteriophage%20for%20Aeromonas%20salmonicida.&aulast=Ishiguro&pid=%3Cauthor%3EIshiguro%2c%20E%20E%3bAinsworth%2c%20T%3bShaw%2c%20D%20H%3bKay%2c%20W%20W%3bTrust%2c%20T%20J%3C%2Fauthor%3E%3CAN%3E19842237525%3C%2FAN%3E%3CDT%3EJournal%20article%3C%2FDT%3
Dynamics of the cationic and secretory responses to A-4166 in perifused pancreatic islets
No full textThe dynamics of the cationic and secretory response to A-4166, a hypoglycemic meglitinide analogue, was investigated in rat islets prelabelled with either 86Rb or 45Ca and placed in a perifusion system. In the absence of D-glucose, A-4166 (10 μM) provoked an immediate, sustained and rapidly reversible inhibition of 86Rb outflow, this contrasting with a short-lived stimulation of insulin release. In the presence of 6 mM D-glucose, A-4166 provoked a rapid, sustained and rapidly reversible stimulation of both insulin release and 45Ca efflux. The latter cationic response was suppressed in the absence of extracellular Ca2+, in which case A-4166 even caused a modest decrease in effluent radioactivity.These findings support the view that A-4166 acts mainly in the islet B-cell by closing ATP-responsive K+ channels, leading to subsequent depolarization of the plasma membrane and gating of voltage-sensitive Ca2+ channels. Independently of the latter effect, A-4166 may also affect the intracellular distribution of Ca2+ ions. The present data further indicate that A-4166 belongs to those hypoglycemic agents that cause rapidly reversible changes in cationic and secretory events, at variance with highly potent sulfonylureas such as glibenclamide or glimepiride.SCOPUS: ar.jFLWINinfo:eu-repo/semantics/publishe
Linked collectors and determiners for: Colecciones históricas de México: E.K. Balls (1938). Donación del Herbario Kew.
No full textNatural history specimen data linked to collectors and determiners held within, "Colecciones históricas de México: E.K. Balls (1938). Donación del Herbario Kew". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/596c299b-fbeb-4166-b2db-09b5d078638e">https://bionomia.net/dataset/596c299b-fbeb-4166-b2db-09b5d078638e</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/596c299b-fbeb-4166-b2db-09b5d078638e">https://gbif.org/dataset/596c299b-fbeb-4166-b2db-09b5d078638e</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: University of Cincinnati, Margaret H. Fulford Herbarium - Fungi.
No full textNatural history specimen data linked to collectors and determiners held within, "University of Cincinnati, Margaret H. Fulford Herbarium - Fungi". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/c45bba0f-28ea-4166-b519-ae04673541f4">https://bionomia.net/dataset/c45bba0f-28ea-4166-b519-ae04673541f4</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/c45bba0f-28ea-4166-b519-ae04673541f4">https://gbif.org/dataset/c45bba0f-28ea-4166-b519-ae04673541f4</a>. Formatted as a Frictionless Data package
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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