1,724,865 research outputs found
Clinical characteristics of participants (n = 4124).
No full text<p>Clinical characteristics of participants (n = 4124).</p
PROBING CIRCUMSTELLAR MOLECULAR GAS IN THE STAR-FORMING REGION
No full textAuthor Institution: Astronomy Department, University of Illinois at Urbana-ChampaignAs a well known cluster system that has simultaneous low and high-mass star formation, the region can provide an interesting laboratory for star formation studies. The cluster associated with , a Herbig Be star at a distance of 1 kpc, includes two other optically visible young stars, V 1686 Cygni and V1318 Cygni, and several embedded IR sources. We present the BIMA interferometric images of CS , and to probe the molecular gas distribution and morphology and derive the gas column density and molecular mass. By comparsion with near infrared observations, we identify more embedded sources showing ongoing star-forming activities and study the formation mechanism and interaction between the high mass star and low mass companions. Finally, the impact to general star formation will be discussed
Block Card 4124 Lewis Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling | 4124 Lewis Avenue (Toledo, Ohio) | Willys Park Area (Toledo, Ohio) | West Toledo Area (Toledo, Ohio) | Cross gabled | Folk House Styl
Block Card 4124 Peak Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Bungalow Style | Dwelling | 4124 Peak Avenue (Toledo, Ohio) | Willys Park Area (Toledo, Ohio) | West Toledo Area (Toledo, Ohio
Linked collectors and determiners for: Herbarium specimens of Société des Sciences Naturelles et Mathématiques de Cherbourg (CHE).
No full textNatural history specimen data linked to collectors and determiners held within, "Herbarium specimens of Société des Sciences Naturelles et Mathématiques de Cherbourg (CHE)". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/646858f7-8620-4124-9405-279539aec76c">https://bionomia.net/dataset/646858f7-8620-4124-9405-279539aec76c</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/646858f7-8620-4124-9405-279539aec76c">https://gbif.org/dataset/646858f7-8620-4124-9405-279539aec76c</a>. Formatted as a Frictionless Data package
CDB-4124, a Progesterone Receptor Modulator, Inhibits Mammary Carcinogenesis by Suppressing Cell Proliferation and Inducing Apoptosis
No full textAbstract
CDB-4124 (Proellex or telapristone acetate) is a modulator of progesterone receptor (PR) signaling, which is currently employed in preclinical studies for prevention and treatment of breast cancer and has been used in clinical studies for treatment of uterine fibroids and endometriosis. Here we provide evidence for its action on steroid hormone-signaling, cell cycle–regulated genes and in vivo on mammary carcinogenesis. When CDB-4124 is given to rats at 200 mg/kg for 24 months, it prevents the development of spontaneous mammary hyperplastic and premalignant lesions. Also, CDB-4124 given as subcutaneous pellets at two different doses suppressed, dose dependently, N-methyl-N-nitrosourea (MNU)-induced mammary carcinogenesis. The high dose (30 mg, over 84 days) increased tumor latency from 66 ± 24 days to 87 ± 20 days (P &lt; 0.02), decreased incidence from 85% to 35% (P &lt; 0.001), and reduced multiplicity from 3.0 to 1.1 tumors/animal (P &lt; 0.001). Tumor burden decreased from 2.6 g/animal to 0.26 g/animal (P &lt; 0.01). CDB-4124 inhibited cell proliferation and induced apoptosis in MNU-induced mammary tumors, which correlated with a decreased proportion of PR+ tumor cells and with decreased serum progesterone. CDB-4124 did not affect serum estradiol. In a mechanistic study employing T47D cells we found that CDB-4124 suppressed G1/G0–S transition by inhibiting CDK2 and CDK4 expressions, which correlated with inhibition of estrogen receptor (ER) expression. Taken together, these data indicate that CDB-4124 can suppress the development of precancerous lesions and carcinogen-induced ER+ mammary tumors in rats, and may have implications for prevention and treatment of human breast cancer. Cancer Prev Res; 4(3); 414–24. ©2011 AACR.</jats:p
Linked collectors and determiners for: Herbarium specimens of Société des Sciences Naturelles et Mathématiques de Cherbourg (CHE).
No full textNatural history specimen data linked to collectors and determiners held within, "Herbarium specimens of Société des Sciences Naturelles et Mathématiques de Cherbourg (CHE)". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/646858f7-8620-4124-9405-279539aec76c">https://bionomia.net/dataset/646858f7-8620-4124-9405-279539aec76c</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/646858f7-8620-4124-9405-279539aec76c">https://gbif.org/dataset/646858f7-8620-4124-9405-279539aec76c</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: A revision of the genus Eutetrapha Bates (Coleoptera: Cerambycidae: Lamiinae: Saperdini).
No full textNatural history specimen data linked to collectors and determiners held within, "A revision of the genus Eutetrapha Bates (Coleoptera: Cerambycidae: Lamiinae: Saperdini)". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/56cec7e4-4124-47a3-8434-da195642f91d">https://bionomia.net/dataset/56cec7e4-4124-47a3-8434-da195642f91d</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/56cec7e4-4124-47a3-8434-da195642f91d">https://gbif.org/dataset/56cec7e4-4124-47a3-8434-da195642f91d</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: A revision of the genus Eutetrapha Bates (Coleoptera: Cerambycidae: Lamiinae: Saperdini).
No full textNatural history specimen data linked to collectors and determiners held within, "A revision of the genus Eutetrapha Bates (Coleoptera: Cerambycidae: Lamiinae: Saperdini)". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/56cec7e4-4124-47a3-8434-da195642f91d">https://bionomia.net/dataset/56cec7e4-4124-47a3-8434-da195642f91d</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/56cec7e4-4124-47a3-8434-da195642f91d">https://gbif.org/dataset/56cec7e4-4124-47a3-8434-da195642f91d</a>. Formatted as a Frictionless Data package
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