1,806,286 research outputs found
Resolución Rectoral Nº 380/2021. Aprobar el dictado de la "Diplomatura de Extensión Universitaria denominada "Cuidados Integrales en Salud".
No full textFil: Rector (R). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución Rectoral Nº 380/2021. Aprobar el dictado de la "Diplomatura de Extensión Universitaria denominada "Cuidados Integrales en Salud" , a desarrollarse durante el
ciclo lectivo 2021, con una carga horaria de 92 horas reloj, según la propuesta formativa y equipo docente.tru
PowerTAC 2015-04 Qualifying 376-380
No full text<p>Log and boot files of games 376 - 380</p>
N(6)-methyladenosine-mediated miR-380-3p maturation and upregulation promotes cancer aggressiveness in pancreatic cancer
No full textN(6)-methyladenosine (m6A)-modified microRNAs (miRNAs) are relevant to cancer progression. Also, although the involvement of miR-380-3p in regulating cancer progression in bladder cancer and neuroblastoma has been preliminarily explored, its role in other types of cancer, such as pancreatic cancer (PC), has not been studied. Thus, this study aimed to investigate the role of miR-380-3p in regulating PC progression. Here, through performing Real-Time qPCR, we evidenced that miR-380-3p was significantly upregulated in the clinical pancreatic cancer tissues and cells compared to their normal counterparts. Interestingly, miR-380-3p was enriched with m6A modifications, and elimination of m6A modifications by deleting METTL3 and METTL14 synergistically suppressed miR-380-3p expressions in PC cells. Next, the gain and loss-of-function experiments verified that knockdown of miR-380-3p suppressed cell proliferation, epithelial–mesenchymal transition (EMT), and tumorigenesis in PC cells in vitro and in vivo, whereas miR-380-3p overexpression had opposite effects. Furthermore, the underlying mechanisms were uncovered, and our data suggested that miR-380-3p targeted the 3’ untranslated regions (3ʹUTRs) of PTEN for its inhibition and degradation, resulting in the activation of the downstream Akt signal pathway. Moreover, the rescuing experiments validated that both PTEN overexpression and Akt pathway inhibitor LY294002 abrogated the promoting effects of miR-380-3p overexpression on cancer aggressiveness in PC cells. Collectively, this study firstly investigated the role of the m6A-associated miR-380-3p/PTEN/Akt pathway in regulating PC progression, which provided novel therapeutic and diagnostic biomarkers for this cancer.</p
Resolución UNRN N° 380/2009. Contratar personal temporario
No full textFil: Universidad Nacional de Río Negro (U). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución UNRN N° 380/2009. Contratar personal temporariofals
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Gemeindenachrichten Ottensheim 2016 / 380 (2016 / 380)
No full textGEMEINDENACHRICHTEN OTTENSHEIM 2016 / 380
Gemeindenachrichten Ottensheim (-)
Gemeindenachrichten Ottensheim 2016 / 380 (2016 / 380) ([1]
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Closing Remarks of the International Astronomical Union Symposium 380
No full textClosing remarks on the IAUS 380We are pleased to summarise the IAU Symposium 380, Cosmic Masers: Proper Motion toward the Next-Generation Large Projects held on March 2023 March 20-24 in Kagoshima City, Japan. It is the sixth symposium focusing on astrophysical masers broadly used in research of star formation and evolved stars, astrometric measurements of the Milky Way galaxy, as well as studies of extragalactic environments.The National Science Centre, Poland through grant 2021/43/B/ST9/02008
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