1,725,132 research outputs found
MicroRNA-3666 Regulates Thyroid Carcinoma Cell Proliferation via MET
No full textBackground/Aims: Thyroid carcinoma (TC) is a highly lethal malignant cancer and its carcinogenesis remains undetermined. Dysregulation of microRNAs (miRNAs) is well known to be involved in the development of various cancers, including TC, whereas a role of miR-3666 in the pathogenesis of TC has not been appreciated. Methods: We analyzed the levels of MET and miR-3666 in TC tissue and the relationship of miR-3666 levels with patients' prognosis. We then overexpressed miR-3666 by miRNA mimics transfection and inhibited miR-3666 by miRNA antisense transfection in TC cells. Cell survival and growth were analyzed by CCK-8 assay and MTT assay, respectively. Cell apoptosis and proliferation were analyzed by flow cytometry. Bioinformatics analyses were applied to predict miR-3666 targets, which was then confirmed using luciferase reporter assay. Results: We detected significantly higher levels of MET, and significantly lower levels of miR-3666 in TC tissue, compared to the adjacent non-tumor tissue. Moreover, the low miR-3666 levels were associated with poor survival of the patients. Overexpression of miR-3666 significantly inhibited cell growth, while depletion of miR-3666 increased cell growth in TC cells. Moreover, the effects of miR-3666 on cell growth appeared to result from alteration in cell proliferation, rather than changes in cell apoptosis. MiR-3666 was found to bind to the 3'-UTR of MET mRNA to inhibit its translation in TC cells. Conclusion: Reduced miR-3666 levels in TC tissue may promotes TC growth, possibly through MET-mediated cell proliferation
miR-3666 inhibits lung cancer cell proliferation, migration and invasion by targeting BPTF
No full textOur previous study suggested that BPTF overexpression was observed in lung adenocarcinoma, and closely associated with advanced clinical stage, more metastatic lymph nodes, present distant metastasis, low histological grade and poor prognosis. Down-regulation of BPTF inhibited lung adenocarcinoma cells proliferation and promoted lung adenocarcinoma cells apoptosis. The purpose of this study is to identify valuable microRNAs (miRNAs), which target BPTF to modulate lung adenocarcinoma cells proliferation. In our results, we found that miR-3666 was notably reduced in lung adenocarcinoma tissues and cell lines. By using miR-3666 mimics, cells proliferation, migration, and invasion were suppressed by miR-3666 overexpression, while were enhanced by reduction of miR-3666. Moreover, bioinformatics analysis using Targetscan database and miRanda software suggested a putative targeting site in BPTF 3â -UTR. Furthermore, we verified that miR-3666 directly targeted to 3â -UTR of BPTF by luciferase reporter assay. Overexpression of miR-3666 negatively regulated protein expression of BPTF by western blot. Finally, PI3K/AKT and EMT was demonstrated to be inhibited by miR-3666 overexpression in lung cancer cells. In conclusion, our data indicate that miR-3666 might play an essential role in cell proliferation, migration and invasion by targeting BPTF and partly inhibited PI3K/AKT and EMT signaling pathways in human lung cancers.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author
Marsh, Frederick W L, On B-3666
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/401591Surname: MARSH. Given Name(s) or Initials: FREDERICK W L. Military Service Number or Last Known Location: ON B-3666. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 57134.221237
Item: [2016.0049.33884] "Marsh, Frederick W L, On B-3666
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Upper (a) and lower (b) right toothrow of <i>M</i>. <i>albicaudatus</i> (DNMNH-3666).
No full textUpper (a) and lower (b) right toothrow of M. albicaudatus (DNMNH-3666).</p
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Lincoln Income Life Insurance Company - Louisville, Kentucky (SC 3666)
No full textFinding aid only for Manuscripts Small Collection 3666. Magazine-style supplement to the Louisville Courier-Journal, 13 March 1966, profiling the personnel and operations of the Lincoln Income Life Insurance Company. The well-illustrated publication highlights the company’s new home office building, the Lincoln Tower, designed by Taliesin Associated Architects, and includes a color rendering of the building on the cover
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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