1,724,380 research outputs found
MiR-3662 suppresses hepatocellular carcinoma growth through inhibition of HIF-1α-mediated Warburg effect
No full textAbstractGlucose metabolic reprogramming from oxidative to aerobic glycolysis, referred as the Warburg effect, is a hallmark of tumor cells. Accumulating evidence suggests that a subset of microRNAs play pivotal roles in modulating such reprogramming of glucose metabolism in cancer cells. miR-3662 has been implicated previously in both pro-tumorigenic and anti-tumorigenic effects in several types of cancer. The expression level of miR-3662 is downregulated in acute myeloid leukemia, whereas increased miR-3662 expression is observed in lung adenocarcinoma. However, the roles and underlying mechanisms of miR-3662 in hepatocellular carcinoma (HCC) metabolic reprogramming remain unclear. Our present study revealed that miR-3662 was frequently downregulated in HCC tissues and cell lines. The low expression level of miR-3662 was associated with tumor size, tumor multiplicity, Edmondson grade, and tumor-node-metastasis stage. Gain-of-function and loss-of-function assays showed that miR-3662 dampened glycolysis by reducing lactate production, glucose consumption, cellular glucose-6-phosphate level, ATP generation, and extracellular acidification rate, and increasing oxygen consumption rate in HCC cells after treatment with the hypoxia mimetic CoCl2. Moreover, miR-3662 suppressed cell growth in vitro and in vivo, and induced G1/S cell cycle arrest. miR-3662 inhibited the activation of ERK and JNK signaling pathways in HCC. By combined computational and experimental approaches, hypoxia-inducible factor-1α (HIF-1α) was determined as a direct target of miR-3662. After treatment with the hypoxia mimetic CoCl2, miR-3662 regulated the Warburg effect and HCC progression via decreasing HIF-1α expression. Our findings uncover a mechanistic role for miR-3662/HIF-1α axis in HCC metabolic reprogramming, providing a potential therapeutic strategy in liver cancer.</jats:p
Block Card 3662 Almeda Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: dwelling | 3662 Almeda Drive (Toledo, Ohio) | Colonial Revival Style | Almeda Heights (Toledo, Ohio) | Willys Park area (Toledo, Ohio) | West Toledo (Toledo, Ohio
Block Card 3662 Perlawn Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 3662 Perlawn Drive (Toledo, Ohio) | Dwelling | Heatherlawn Heights (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
Maudie - Letter to (SC 3662)
Get PDFFinding aid and scan (Click on Additional Files below) for Manuscripts Small Collection 3662. Letter, 26 March 1892, to Maudie at school, from her father “Geo W B” in Moark, Arkansas. He hopes she is learning and behaving, promises to “catch a big fish” for her homecoming, and tells her that her “Red bird” sings every morning
Block Card 3662 Kenwood Boulevard
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 3662 Kenwood Boulevard (Toledo, Ohio) | attached garage | Old Orchard Addition, Third Extension (Toledo, Ohio) | Westgate Area (Toledo, Ohio
Block Card 3662 Treelawn Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 3662 Treelawn Drive (Toledo, Ohio) | Dwelling | Heatherway Plat (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Calathea sp. from Colombia collected by A. Camargo, E. Álvarez, F. Toro #3662
No full textFile Name: TOLI-23727-ZAR-05-Sot-Reb-EAD-3662.jpg
CÓDIGO FOTO: TOLI-23727-ZAR-05-Sot-Reb-EAD-3662-
Fotografía: SI
Nº TOLI: TOLI-23727
PARCELA: ZAR-05
CÓDIGO: Sot-Reb-EAD-3662
Nº COLECTA: 3662
NUEVOS COLECTORES: Alejandro Camargo, Felipe Toro & Esteban Alvarez
COLECTORES: A. Camargo, E. Álvarez, F. Toro
Nº MUESTRAS MONTADAS: 1
Homologación: No homologado
Nueva fecha del evento : 30/11/2018.
Fecha del evento: 15/10/2006.
Proyecto : Recursos Botánicos Disponibles en Línea (BRAVO) para la flora Colombiana
Hábitat: Bosque húmedo tropical (bh-T)
Comentario del evento: Bosque de tierra firme
Continente: SA
Pais: Colombia
Estado/Provincia: Amazonas
Municipio: Leticia
Localidad: Resguardo Indígena Ticuna-Huitoto Km 6-11.
Elevación minima en metros: 200
Elevación maxima en metros: 300
Latitud: -4.004
Longitud original: -69.896
datum geodésico: WGS 84
Latitud decimal: -4.004
Longitud decimal: -69.896
Identificado por: Diego Suescún
Fecha de identificación: 15/02/2019.
Nombre cientifico: Calathea sp.
Reino: Plantae
Filo: Magnoliophyta
Clase: Equisetopsida
Orden: Zingiberales
Familia nueva: Marantaceae
Género nuevo: Calathea
especie nueva: sp.
: Marantaceae
genero herbario: Calathea
especie herbario: sp.
Especie de herbario para TNRS: Calathea sp.
Especie corregida herbario y desde TNRS: Calathea indet
Familia corregida desde TNRS: Marantaceae
: 2815</p
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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