1,804,711 research outputs found
The Beginning of Process: 1 of 366 prints taken from the same plate and The End of Process: 366 of 366 prints taken from the same plate
No full textPrints numbers 1 and 366 from the series 366:366 (finally) were exhibited in the All the Small Things exhibition, Artcore, Derby, September 2021.
For the leap year of 2016 I exhaled on an etching plate every day. 366 breaths layered on the same surface, in the same place, and at roughly the same time. The accumulative breaths charted the process of isolating and capturing those layered singular exhalations, and over the next 4 years the act was reversed through printmaking methods. ‘366:366 (finally)’ was a work in and indebted to process; a series of prints made from the etched plate to match the number of breaths which scored its image
Feature: Angela Bartram - 366:366 (eventually; animated; finally), 2016-2020
No full textFor the leap year of 2016 I exhaled on an etching plate every day, at roughly 8pm. 366 breaths layered on the same surface, in the same place, and at roughly the same time. Each breath took about four seconds to lay on an A5 zinc etching plate. So, roughly 1464 seconds in total, or just over twenty-four minutes, or a third of an hour…that is a lot of breath. I had worked with the mouth as an instrument for drawing and object making in performances and other ways for years, and this work is part of that practice. The mouth, what some theorists would term a vulnerable orifice, made useful and invulnerable (perhaps) through creative process. But surely this was doomed to failure, for how could breathing produce an image in this way? Really, I didn’t care. For this was an exploration of repetition within process, the mundane within the order of making
Wickerhamomyces anomalus NRRL Y-366-8 Genome sequencing
No full textWickerhamomyces anomalus NRRL Y-366-8 Genome sequencin
Resolución UNRN N° 366/2009. Contratar personal temporario
No full textFil: Universidad Nacional de Río Negro (U). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución UNRN N° 366/2009. Contratar personal temporariofals
Gemeindenachrichten Ottensheim 2014 / 366 (2014 / 366)
No full textGEMEINDENACHRICHTEN OTTENSHEIM 2014 / 366
Gemeindenachrichten Ottensheim (-)
Gemeindenachrichten Ottensheim 2014 / 366 (2014 / 366) ([1]
Participant 366 Community Conversations Interview
No full textIn this interview, Participant 366 shares their experience as a student during the COVID-19 pandemic. The participant discusses challenges with remote learning and social isolation. The participant says they experienced technologic difficulties, especially in the beginning of the pandemic. They share that they have been able to stay in touch with friends using technology. The participant expresses that they are looking forward to being in-person again, and are surprised others not taking the pandemic seriously enough. They are appreciative of having the time and opportunity to immerse themselves in their hobbies.New Jersey Department of Healt
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Bulletin No. 366 - Indian Ranching on the Wind River Reservation, Wyoming
No full textBulletin No. 366 - Indian Ranching on the Wind River Reservation, Wyomin
Molecular dynamics investigations of structural and functional changes in Bcl-2 induced by the novel antagonist BDA-366
No full textApoptosis is a fundamental biological phenomenon, in which anti- or proapoptotic proteins of the Bcl-2 family regulate a committed step. Overexpression of Bcl-2, the prototypical antiapoptotic protein in this family, is associated with therapy resistance in various human cancers. Accordingly, Bcl-2 inhibitors intended for cancer therapy have been developed, typically against the BH3 domain. Recent experimental evidences have shown that the antiapoptotic function of Bcl-2 is not immutable, and that BDA-366, a novel antagonist of the BH4 domain, converts Bcl-2 from a survival molecule to an inducer of cell death. In this study, the underlying mechanisms of this functional conversion were investigated by accelerated molecular dynamics simulation. Results revealed that Pro127 and Trp30 in the BH4 domain rotate to stabilize BDA-366 via π-π interactions, and trigger a series of significant conformational changes of the α3 helix. This rearrangement blocks the hydrophobic binding site (HBS) in the BH3 domain and further prevents binding of BH3-only proteins, which consequently allows the BH3-only proteins to activate the proapoptotic proteins. Analysis of binding free energy confirmed that BDA-366 cross-inhibits BH3-only proteins, implying negative cooperative effects across separate binding sites. The newly identified blocked conformation of the HBS along with the open to closed transition pathway revealed by this study advances the understanding of the Bcl-2 transition from antiapoptotic to proapoptotic function, and yielded new structural insights for novel drug design against the BH4 domain. Communicated by Ramaswamy H. Sarma The ability of the small molecule BDA-366 to convert Bcl-2 from an antiapoptotic to a proapoptotic molecule was investigated by accelerated molecular dynamics simulation. Results show that BDA-366 blocks or reduces the affinity of Bcl-2 for BH3-only proteins like Bid via negative cooperative effects, thereby releasing such proteins and unleashing their proapoptotic effects.</p
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