1,725,774 research outputs found
Union Pacific (UP) 3656
No full textA photograph print showing Union Pacific (UP) 3656, 2-8-8-0 (compound), on eastbound freight extra, Laramie, WY
Block Card 3656 Rushland Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Modern Colonial Style | Dwelling | 3656 Rushland Avenue (Toledo, Ohio) | Extension of Forest View Addition (Toledo, Ohio) | Deveaux Area (Toledo, Ohio) | West Toledo (Toledo, Ohio
Block Card 3656 Torrance Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: dwelling | 3656 Torrance Drive | Hipped roof Ranch Style | Almeda Heights (Toledo, Ohio) | Willys Park area (Toledo, Ohio) | West Toledo (Toledo, Ohio
miR-3656 expression enhances the chemosensitivity of pancreatic cancer to gemcitabine through modulation of the RHOF/EMT axis
No full textAbstractThe highly refractory nature of pancreatic cancer (PC) to chemotherapeutic drugs is one of the key reasons contributing to the poor prognosis of this disease. MicroRNAs (miRNAs) are key regulators of gene expression and have been implicated in a variety of processes from cancer development through to drug resistance. Herein, through miRNA profiling of gemcitabine-resistant (GR) and parental PANC-1 cell lines, we found a consistent reduction of miR-3656 in GR PANC-1 cells. miR-3656 overexpression enhanced the antitumor effect of gemcitabine, whereas silencing of miR-3656 resulted in the opposite effect. By performing mechanistic studies using both in vitro and in vivo models, we found that miR-3656 could target RHOF, a member of the Rho subfamily of small GTPases, and regulate the EMT process. Moreover, enforced EMT progression via TWIST1 overexpression compromised the chemotherapy-enhancing effects of miR-3656. Finally, we found significantly lower levels of miR-3656 and higher levels of RHOF in PC tissues compared with adjacent noncancerous pancreatic tissues, and this was also associated with poor PC patients’ prognosis. Taken together, our results suggest that the miR-3656/RHOF/EMT axis is an important factor involved in regulating GR in PC, and highlights the potential of novel miR-3656-based clinical modalities as a therapeutic approach in PC patients.</jats:p
HI in the shell elliptical galaxy NGC 3656
No full textVery Large Array(7) neutral hydrogen observations of the shell elliptical galaxy NGC 3656 reveal an edge-on, warped minor-axis gaseous disk (M (H I) similar to 2 x 10(9) M-circle dot) extending 7 kpc. H I is also found outside the optical image, on two complexes to the northeast and northwest that seem to trace one or two tidal tails, or possibly an outer broken H I disk or ring. These complexes link with the outer edges of the inner disk and appear displaced with respect to the two optical tails in the galaxy. The disk kinematics is strongly lopsided, suggesting recent or ongoing accretion. Integral-field optical fiber spectroscopy at the region of the bright southern shell of NGC 3656 has provided a determination of the stellar velocities of the shell. The shell, at 9 kpc from the center, has traces of H I with velocities bracketing the stellar velocities, providing evidence for a dynamical association of H I and stars at the shell. Within the errors the stars have systemic velocity, suggesting a possible phase-wrapping origin for the shell. We probed a region of 40' x 40' (480 kpc x 480 kpc) x 1160 km s(-1) down to an H I mass sensitivity (6 sigma) of 3 x 10(7) M-circle dot and detect five dwarf galaxies with H I masses ranging from 2 x 10(8) to 2 x 10(9) M-circle dot, all within 180 kpc of NGC 3656 and all within the velocity range (450 km s(-1)) of the H I of NGC 3656. The dwarfs had been previously cataloged, but none had a known redshift. For the NGC 3656 group to be bound requires a total mass of (3-7.4) x 10(12) M-circle dot, yielding a mass-to-light ratio from 125 to 300. The overall H I picture presented by NGC 3656 supports the hypothesis of a disk-disk merger origin or possibly an ongoing process of multiple mergers with nearby dwarfs.</p
HI in the shell elliptical galaxy NGC 3656
No full textVery Large Array(7) neutral hydrogen observations of the shell elliptical galaxy NGC 3656 reveal an edge-on, warped minor-axis gaseous disk (M (H I) similar to 2 x 10(9) M-circle dot) extending 7 kpc. H I is also found outside the optical image, on two complexes to the northeast and northwest that seem to trace one or two tidal tails, or possibly an outer broken H I disk or ring. These complexes link with the outer edges of the inner disk and appear displaced with respect to the two optical tails in the galaxy. The disk kinematics is strongly lopsided, suggesting recent or ongoing accretion. Integral-field optical fiber spectroscopy at the region of the bright southern shell of NGC 3656 has provided a determination of the stellar velocities of the shell. The shell, at 9 kpc from the center, has traces of H I with velocities bracketing the stellar velocities, providing evidence for a dynamical association of H I and stars at the shell. Within the errors the stars have systemic velocity, suggesting a possible phase-wrapping origin for the shell. We probed a region of 40' x 40' (480 kpc x 480 kpc) x 1160 km s(-1) down to an H I mass sensitivity (6 sigma) of 3 x 10(7) M-circle dot and detect five dwarf galaxies with H I masses ranging from 2 x 10(8) to 2 x 10(9) M-circle dot, all within 180 kpc of NGC 3656 and all within the velocity range (450 km s(-1)) of the H I of NGC 3656. The dwarfs had been previously cataloged, but none had a known redshift. For the NGC 3656 group to be bound requires a total mass of (3-7.4) x 10(12) M-circle dot, yielding a mass-to-light ratio from 125 to 300. The overall H I picture presented by NGC 3656 supports the hypothesis of a disk-disk merger origin or possibly an ongoing process of multiple mergers with nearby dwarfs
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Woods, Edgar Hall, 1864-1939 (SC 3656)
Full text linkFinding aid and scan (Click on Additional Files below) for Manuscripts Small Collection 3656. Letter, 3 May 1915, from E. H. Woods of Woods Hall Ranch, Pageville, Kentucky and Malvina Plantation, Malvina, Mississippi, to Lester Carter, Knob Lick, Kentucky. Woods writes of his wish to have Carter paint a portrait from a photograph of a young boy on a pony, but regrets his inability to meet Carter’s price
- …
