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Block Card 3609 Beverly Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Split-Level Style | 3609 Beverly Drive (Toledo, Ohio) | Dwelling | Hietts Beverly Boulevard Addition (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
Memo re: American Airlines Board Option Docket No. 3609
No full textMemo from American Airlines Board Action Docker No. 3609
3609. Archives de la chambre des comptes de Blois
No full text3609. Archives de la chambre des comptes de Blois. In: Molinier Auguste. Les Sources de l'histoire de France - Des origines aux guerres d'Italie (1494). IV. Les Valois, 1328-1461. Paris : A. Picard et fils, 1904. p. 131
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
The amoebal MAP kinase response to Legionella pneumophila is regulated by DupA
Full text linkThe amoeba Dictyostelium discoideum can support replication of Legionella pneumophila. Here we identify the dupA gene, encoding a putative tyrosine kinase/dual-specificity phosphatase, in a screen for D. discoideum mutants altered in allowing L. pneumophila intracellular replication. Inactivation of dupA resulted in depressed L. pneumophila growth and sustained hyperphosphorylation of the amoebal MAP kinase ERK1, consistent with loss of a phosphatase activity. Bacterial challenge of wild-type amoebae induced dupA expression and resulted in transiently increased ERK1 phosphorylation, suggesting that dupA and ERK1 are part of a response to bacteria. Indeed, over 500 of the genes misregulated in the dupA(-) mutant were regulated in response to L. pneumophila infection, including some thought to have immune-like functions. MAP kinase phosphatases are known to be highly upregulated in macrophages challenged with L. pneumophila. Thus, DupA may regulate a MAP kinase response to bacteria that is conserved from amoebae to mammals
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High miR-3609 expression is associated with better prognosis in TNBC based on mining using systematic integrated public sequencing data
Full text linkMicroRNAs (miRNAs/miRs) are small endogenous RNAs that regulate gene expression post-transcriptionally. Abnormal miR-3609 expression is associated with the occurrence of pancreatic cancer, glioma and other diseases, such as polycystic ovary syndrome. However, the prognostic potential of miR-3609 has been reported in breast cancer. Thus, the present study aimed to investigate the differential expression and prognostic value of miR-3609 in patients with breast cancer from the UALCAN, cBioportal and Kaplan-Meier Plotter databases, respectively. Furthermore, the co-expression genes of miR-3609 in breast cancer were investigated using data from the LinkedOmics database, and functional enrichment analysis was performed using the LinkInterpreter module in LinkedOmics. The co-expression gene network was constructed using the Search Tool for the Retrieval of Interacting Genes/Proteins database, and the cytoHubba plug-in was used to identify the hub genes, which were visualized using Cytoscape software. The prognoses of the hub genes were performed using the Kaplan-Meier Plotter database. The Cell Counting Kit-8 and cell cycle assays were performed to confirm the functions of miR-3609 mimics transfection in MDA-MB-231 cells. Survival analysis using the Kaplan-Meier Plotter database demonstrated that high miR-3609 expression in triple-negative breast cancer (TNBC) was associated with a better prognosis. Furthermore, the experimental results indicated that high miR-3609 expression inhibited the proliferation of TNBC cells and induced cell cycle arrest of TNBC cells in the G
0
/G
1
phase. Taken together, the results of the present study suggest that miR-3609 plays a vital role in mediating cell cycle arrest and inhibiting the proliferation of TNBC cells
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Identificació dels gens regulats pel microARN miR-3609, associat a pronòstic funcional de l’ictus isquèmic d’etiologia criptogènica
No full text[cat] L'ictus és la segona causa principal de discapacitat i mort arreu del món, amb una
incidència creixent a causa del canvi demogràfic i l'augment de les malalties
cardiovasculars. Recentment, s'ha identificat que el miR-3609 està associat amb un
pronòstic funcional favorable en l’ictus isquèmic d’etiologia criptogènica. L'objectiu
principal d’aquest treball de fi de màster ha estat identificar els gens diana regulats per
aquest miRNA. Per aconseguir-ho, s’han realitzat estudis de transfecció gènica emprant
molècules sintètiques mimètiques i inhibidores del miR-3609 endogen en cèl·lules
endotelials microvasculars cerebrals humanes immortalitzades (hCMEC/d3).
Posteriorment, s’ha estudiat el perfil d’expressió gènica mitjançant l’anàlisi de l’ARNm
i de la proteïna en condicions de normòxia i hipòxia. Els resultats assenyalen el gen
CRYAB, que codifica per la xaperona αB-cristal·lina, com a gen diana del miR-3609.
Aquesta proteïna podria actuar en resposta a la hipòxia per induir un estat proinflamatori
en les cèl·lules endotelials cerebrals. A més, s’ha observat que el miR-3609 regula
CRYAB, inhibint la seva expressió en condicions d’hipòxia prolongada. Això suggereix
que el miR-3609 podria ser una diana terapèutica en el futur per millorar el pronòstic
funcional de pacients joves que hagin patit un ictus d’etiologia criptogènica[eng] Stroke is the second leading cause of disability and death worldwide, with a growing
incidence due to demographic changes and the increase in cardiovascular diseases.
Recently, miR-3609 has been identified as being associated with a favorable functional
prognosis in cryptogenic ischemic stroke. The main objective of this master's thesis was
to identify the target genes regulated by this miRNA. To achieve this, transfection
experiments to introduce synthetic mimetic and inhibitory molecules of endogenous miR3609 into immortalized human brain microvascular endothelial cells (hCMEC/d3) were
performed. Subsequently, the gene expression profile was studied through mRNA and
protein analysis under normoxic and hypoxic conditions. The results indicate that CRYAB
gene, which encodes the αB-crystallin chaperone, is a target gene of miR-3609. This
protein may respond to hypoxia by inducing a pro-inflammatory state in brain endothelial
cells. Additionally, miR-3609 was observed to regulate CRYAB by inhibiting its
expression under prolonged hypoxic conditions. This suggests that miR-3609 could be a
therapeutic target in the future to improve the functional prognosis of young patients who
have suffered a cryptogenic strok
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