1,725,527 research outputs found
3591 North Bear Canyon Road, Miguel Estate
No full textBlueprints of the Mr. and Mrs. John Miguel Estate at 3591 North Bear Canyon Road
Illinois Central Railroad Company (SC 3591)
Get PDFFinding aid and scan (Click on Additional Files below) for Manuscripts Small Collection 3591. Bill of lading issued by the Illinois Central Railroad Company for goods shipped to the McClure Brothers store in Millerstown, Kentucky. The reverse shows a map of the railroad’s routes through the Midwest and South
Additional file 1 of FTO-mediated m6A demethylation of pri-miR-3591 alleviates osteoarthritis progression
No full textAdditional file 1: Supplementary Figure 1. FTO knockdown aggravated LPS-induced chondrocyte damage in vitro. Supplementary Figure 2. miR-3591-5p overexpression aggravated LPS-induced chondrocytes damage by inhibiting PRKAA2. Supplementary Table 1. The sequences of shRNAs, miR-3591-5p inhibitor/mimics, and their negative control in this study. Supplementary Table 2. Primers used for RT-qPCR and other assays in this study
FTO-mediated m6A demethylation of pri-miR-3591 alleviates osteoarthritis progression
No full textAbstract Objectives Increasing evidence have demonstrated the N6-methyladenosine (m6A) plays critical roles in osteoarthritis (OA) progression, but the role of m6A in OA has not been completely illuminated. Herein, we investigated the function and underlying mechanism of m6A demethylase fat mass and obesity-associated protein (FTO) in OA progression. Materials and methods The FTO expression was detected in mice OA cartilage tissues and lipopolysaccharide (LPS)-stimulated chondrocytes. Gain-of-function assays was used to evaluate the role of FTO in OA cartilage injury in vitro and in vivo. The miRNA-sequencing, RNA-binding protein immunoprecipitation (RIP), luciferase reporter assay, and in vitro pri-miRNA processing assays were conducted to confirm that FTO modulated the pri-miR-3591 process in an m6A-dependent manner and then the binding sites of miR-3591-5p with PRKAA2. Results FTO was outstandingly downregulated in LPS-stimulated chondrocytes and OA cartilage tissues. FTO overexpression enhanced the proliferation, suppressed apoptosis, and decreased degradation of extracellular matrix in LPS-induced chondrocytes, whereas FTO knockdown contributed to the opposite effects. In vivo animal experiments showed that FTO overexpression markedly alleviated OA mice cartilage injury. Mechanically, FTO-mediated m6A demethylation of pri-miR-3591 leaded to a maturation block of miR-3591-5p, which relieved the inhibitory effect of miR-3591-5p on PRKAA2 and then promoted the increase of PRKAA2, thereby alleviating OA cartilage damage. Conclusions Our results attested that FTO alleviated the OA cartilage damage by mediating FTO/miR-3591-5p/PRKAA2 axis, which provided fresh insights into the therapeutic strategies for OA
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Heteropsis sp.1 from Colombia collected by E. Álvarez, A. Camargo, F. Toro #3591
No full textFile Name: TOLI-26454-ZAR-05-Sot-alt-EAD-3591.jpg
CÓDIGO FOTO: TOLI-26454-ZAR-05-Sot-alt-EAD-3591-
Fotografía: SI
Nº TOLI: TOLI-26454
PARCELA: ZAR-05
CÓDIGO: Sot-alt-EAD-3591
Nº COLECTA: 3591
NUEVOS COLECTORES: Alejandro Camargo, Felipe Toro & Esteban Alvarez
COLECTORES: E. Álvarez, A. Camargo, F. Toro
Nº MUESTRAS MONTADAS: 1
Homologación: No homologado
Nueva fecha del evento : 30/11/2018.
Fecha del evento: 15/10/2006.
Proyecto : Recursos Botánicos Disponibles en Línea (BRAVO) para la flora Colombiana
Continente: SA
Pais: Colombia
Estado/Provincia: Amazonas
Municipio: Leticia
Localidad: Resguardo Indígena Ticuna-Huitoto Km 6-11.
Elevación minima en metros: 200
Elevación maxima en metros: 300
Latitud: -4.004
Longitud original: -69.896
datum geodésico: WGS 84
Latitud decimal: -4.004
Longitud decimal: -69.896
Identificado por: Diego Suescún
Fecha de identificación: 15/02/2019.
Nombre cientifico: Heteropsis sp.1
Reino: Plantae
Filo: Magnoliophyta
Clase: Equisetopsida
Orden: Alismatales
Familia nueva: Araceae
Género nuevo: Heteropsis
especie nueva: sp.
: Araceae
genero herbario: Heteropsis
especie herbario: sp.
Especie de herbario para TNRS: Heteropsis sp.
Especie corregida herbario y desde TNRS: Heteropsis indet
Familia corregida desde TNRS: Araceae
: 5434</p
Heteropsis sp.1 from Colombia collected by E. Álvarez, A. Camargo, F. Toro #3591
No full textFile Name: TOLI-26454-ZAR-05-Sot-alt-EAD-3591.jpg
CÓDIGO FOTO: TOLI-26454-ZAR-05-Sot-alt-EAD-3591-
Fotografía: SI
Nº TOLI: TOLI-26454
PARCELA: ZAR-05
CÓDIGO: Sot-alt-EAD-3591
Nº COLECTA: 3591
NUEVOS COLECTORES: Alejandro Camargo, Felipe Toro & Esteban Alvarez
COLECTORES: E. Álvarez, A. Camargo, F. Toro
Nº MUESTRAS MONTADAS: 1
Homologación: No homologado
Nueva fecha del evento : 30/11/2018.
Fecha del evento: 15/10/2006.
Proyecto : Recursos Botánicos Disponibles en Línea (BRAVO) para la flora Colombiana
Continente: SA
Pais: Colombia
Estado/Provincia: Amazonas
Municipio: Leticia
Localidad: Resguardo Indígena Ticuna-Huitoto Km 6-11.
Elevación minima en metros: 200
Elevación maxima en metros: 300
Latitud: -4.004
Longitud original: -69.896
datum geodésico: WGS 84
Latitud decimal: -4.004
Longitud decimal: -69.896
Identificado por: Diego Suescún
Fecha de identificación: 15/02/2019.
Nombre cientifico: Heteropsis sp.1
Reino: Plantae
Filo: Magnoliophyta
Clase: Equisetopsida
Orden: Alismatales
Familia nueva: Araceae
Género nuevo: Heteropsis
especie nueva: sp.
: Araceae
genero herbario: Heteropsis
especie herbario: sp.
Especie de herbario para TNRS: Heteropsis sp.
Especie corregida herbario y desde TNRS: Heteropsis indet
Familia corregida desde TNRS: Araceae
: 543
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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