1,724,518 research outputs found
New Evidence on the returns of information systems
Get PDF"January 1994." "Revised June, 1993 and October, 1993; revision of Sloan School WP #3571-93"--Added t.p.Includes bibliographical references (p. 38-40).Supported in part by the MIT Center for Coordination Science (CCS), the MIT Industrial Performance Center (IPC), and the MIT International Financial Services Research Center (IFSRC)by Erik Brynjolfsson [and] Lorin Hitt
Block Card 3571 Schneider Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 3571 Schneider Road (Toledo, Ohio) | Dwelling | Glen Arbor (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
Abstract 3571: The Thioredoxin Reductase Inhibitor Chaetocin has Potent Antineoplastic Effects in Solid Tumors
No full textAbstract
Background: We had previously reported that the natural product chaetocin has potent and selective in vitro, ex vivo and in vivo anti-myeloma activity attributable to the imposition of cellular oxidative stress (ROS) in part mediated via competitive inhibition of the redox enzyme thioredoxin reductase. Having also observed chaetocin-induced cytotoxicity in solid tumor cell lines, we now extend prior work to characterize the effects of chaetocin in solid tumor cell lines and in human umbilical vein endothelial cells (HUVECs). Methods: The effects of chaetocin in solid tumor cell lines were assessed using colony forming assays, trypan blue exclusion assays, apoptosis and autophagy assays, electron microscopy, transcriptional profiling, and the National Cancer Institute 60 cell line screen. Results: Chaetocin demonstrated potent anti-cancer activity in all assessed solid tumor cell lines with IC50 values between 2-10 nM (24 h exposures, colony forming assays). While apoptosis was induced in a cell line-dependant fashion, it was not required for chaetocin-induced cytotoxicity, as ZVAD-fmk prevented apoptosis but not cell death. Markers of autophagy were not altered by chaetocin treatment. Interestingly, results form the NCI 60 cell line screen showed that hematological cell lines were generally more resistant to chaetocin than solid tumor lines despite our prior report indicating the activity of chaetocin in myeloma. Transcriptional profiling results were consistent with those anticipated from an agent producing cell death via imposition of cellular ROS, with heme oxidase-1 prominently induced along with other transcripts in pathways related to inflammatory response and cell death. Results from OxyBlot protein oxidation kit analyses (Millipore, Billerica, MA) confirmed a generalized increase in the carbonyl modification of proteins, a hallmark of cellular oxidative damage, in response to chaetocin treatment. Experiments using Rho0 mitochondrial inactive cells indicated that cellular ROS is induced by chaetocin independent of respiratory functional mitochondria. Chaetocin was also shown to block the interleukin-, fibroblast growth factor- or EGM2 media-induced proliferation of HUVEC cells at low-nanomolar concentrations. Conclusions: Chaetocin has wide-ranging antineoplastic activity across not only hematological, but also solid tumor, cell lines and displays evidence of antiangiogentic activity in HUVEC proliferation assays. Overall, chaetocin appears to be an attractive agent for further development as a candidate anti-cancer therapeutic in a variety of neoplasms. Supported in part by CA125750.
Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3571.</jats:p
Webster, Pauline (Martin) Tabor, 1905-1992 (SC 3571)
Get PDFFinding aid only for Manuscripts Small Collection 3571. Audiocassette recording of Bowling Green, Kentucky madam Pauline Tabor Webster’s appearance on The Dick Cavett Show on 8 March 1972
Linked collectors and determiners for: Equinodermos de la Colección de Referencia de Biología Marina de la Universidad del Valle (CRBMeq-UV).
No full textNatural history specimen data linked to collectors and determiners held within, "Equinodermos de la Colección de Referencia de Biología Marina de la Universidad del Valle (CRBMeq-UV)". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/03a84058-3571-46c8-837f-efd412152734">https://bionomia.net/dataset/03a84058-3571-46c8-837f-efd412152734</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/03a84058-3571-46c8-837f-efd412152734">https://gbif.org/dataset/03a84058-3571-46c8-837f-efd412152734</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: Equinodermos de la Colección de Referencia de Biología Marina de la Universidad del Valle (CRBMeq-UV).
No full textNatural history specimen data linked to collectors and determiners held within, "Equinodermos de la Colección de Referencia de Biología Marina de la Universidad del Valle (CRBMeq-UV)". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/03a84058-3571-46c8-837f-efd412152734">https://bionomia.net/dataset/03a84058-3571-46c8-837f-efd412152734</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/03a84058-3571-46c8-837f-efd412152734">https://gbif.org/dataset/03a84058-3571-46c8-837f-efd412152734</a>. Formatted as a Frictionless Data package
3571. Godefroy (Denis), Histoire du roy Charles VI, Paris, 1653
No full text3571. Godefroy (Denis), Histoire du roy Charles VI, Paris, 1653. In: Molinier Auguste. Les Sources de l'histoire de France - Des origines aux guerres d'Italie (1494). IV. Les Valois, 1328-1461. Paris : A. Picard et fils, 1904. p. 117
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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