1,751,012 research outputs found
Union Pacific (UP) 3523
No full textA photograph postcard showing Union Pacific (UP) 3523, 2-8-8-0, on eastbound freight extra with loco 3805 pushing, Quartz, OR, 64 cars, 30 mph
Abstract 3523: Arginyltransferase1 as a novel suppressor of prostate cancer metastasis
No full textAbstract
Arginylation is a post-translational modification wholly mediated by Arginyltransferase 1 (Ate1). Our studies have shown that Ate1 and arginylation are upregulated during stress conditions. In addition, it was recently shown that Ate1-deficient fibroblasts demonstrate cancer-like characteristics including genomic instability and mutagenesis. While Ate1’s role in cancer is poorly understood, our preliminary studies suggest that Ate1 is an important regulator of metastasis and cancer progression in prostate cancer models. In this study, our data suggests that Ate1 is essential for normal cell stress response in conditions including cellular oxidant, apoptosis inducing drugs, and radiation. Further, we show that a loss of Ate1 in LnCaP prostate cancer cells increases anchorage-independent growth in the soft-agar assay, and that a loss of Ate1 in PC-3 prostate cancer cells increases matrigel invasion in the Boyden chamber assay. To text how Ate1 affects metastasis in vivo, PC-3 cells with Ate1 or control shRNA were orthotopically implanted into the prostates of immunocompromised mice to observe metastasis. While very little metastasis was observed in PC-3 control cells, PC-3 cells with reduced Ate1 achieved much higher levels of metastasis. In conclusion, our data suggests that the loss of Ate1 in prostate cancer promotes cancer progression phenotypes and cell survival. In future studies, we will examine if Ate1 levels in human prostate cancers in prostate cancer prognosis.
Citation Format: Michael Birnbaum, Akhilesh Kumar, William Morgan, Fangliang Zhang. Arginyltransferase1 as a novel suppressor of prostate cancer metastasis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3523. doi:10.1158/1538-7445.AM2017-3523</jats:p
Block Card 3523 Helene Court
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch Style | 3523 Helene Court (Toledo, Ohio) | Dwelling | Wajer-Brooks Addition | Trilby Are
Phocoenoides dalli (Dall's porpoise) - CVM-3523
No full textPhocoenoides dalli (Dall's porpoise) - CVM-3523 - female - unknown length - Pelvic location - Vancouver Museu
Block Card 3523 Oakway Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Cottage style | Dwelling | Beverly Place Addition (Toledo, Ohio) | South Toledo Area (Toledo, Ohio) | 3523 Oakway Drive (Toledo, Ohio
Block Card 3523 Burton Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: dwelling | 3523 Burton Avenue (Toledo, Ohio) | Side Gabled | Craftsman Style | Almeda Heights Second Addition (Toledo, Ohio) | Willys Park area (Toledo, Ohio) | West Toledo (Toledo, Ohio) | Folk House Styl
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Croghan, George, 1852-1911 (SC 3523)
Get PDFFinding aid and scan (Click on Additional Files below) for Manuscripts Small Collection 3523. “The Mammoth Cave Controversy,” a notice by George Croghan of Michigan Bar, Sacramento County, California and a beneficiary of the Mammoth Cave Estate, a trust administered for the heirs of Dr. John Croghan, the Cave’s last private owner. He details numerous grievances against the Estate’s board of trustees: unfilled vacancies, negligent administration, lack of accounting, self-dealing, and falsification of records. He seeks public support for his current pursuit of legal and other remedies
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