1,726,034 research outputs found
3489. Recueil de Dietrich de Niem
No full text3489. Recueil de Dietrich de Niem. In: Molinier Auguste. Les Sources de l'histoire de France - Des origines aux guerres d'Italie (1494). IV. Les Valois, 1328-1461. Paris : A. Picard et fils, 1904. p. 98
Bowling Green, Kentucky - Fire Department (SC 3489)
Full text linkFinding aid and full-text scan of documents (Click on Additional Files below) for Manuscripts Small Collection 3489. Compiled correspondence and documents related to the purchase of fire trucks for the cities of Bowling Green and Smiths Grove in Warren County, Kentucky. Most of the material was scanned and is only available in digital format, but a few original letters and documents were retained
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Abstract 3489: Profound cytotoxicity of the histone deacetylase inhibitor SAHA (Suberoylanilide Hydroxamic Acid) and TRAIL (Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand) combination in malignant pleural mesothelioma
No full textAbstract
Background: The majority of solid malignancies including malignant pleural mesothelioma (MPM) are refractory to TRAIL-mediated cytotoxicity. SAHA has mild antitumor activity against MPM in a phase I clinical trial. This study is designed to evaluate the cytotoxicity of the SAHA+TRAIL combination on a panel of 10 MPM cells and two normal cells (primary fibroblasts and endothelial cells).
Material and methods: Cytotoxicity and apoptosis mediated by TRAIL (0 - 100 ng/ml), SAHA (0.5 - 5.0 microM) or concurrent SAHA+TRAIL combinations are evaluated by MTT assay and AnnexinV-FITC. NF-kB transcriptional activity is measured by luciferase-based reporter plasmid and lucinometer.
Results: MPM cells exhibit a wide range of intrinsic susceptibility to TRAIL (2/10 sensitive: IC50 <50 ng/ml, 5/10 mildly sensitive: IC50: 150 to 2500 ng/ml, 3/10 resistant: IC50: infinity). Profound enhancement of cytotoxicity is observed following treatment with SAHA+TRAIL combinations in 7 MPM cells that exhibit some degrees of TRAIL sensitivity as indicated by 2-fold to >100-fold reduction of TRAIL IC50's. TRAIL-refractory cells H2373, Gats and H2052 are resistant to SAHA+TRAIL combinations. Supra-additive induction of treatment-specific apoptosis is observed in representative Gard and H513 MPM cells treated with this combination (Gard: TRAIL(20ng/ml): 18±5%, SAHA (1 microM): 3±2%, SAHA+TRAIL: 68±5%; H513: TRAIL: 30±5%, SAHA: 2±2%; SAHA+TRAIL: 80±4%, n=3). Combination-induced cytotoxicity and apoptosis is equally abrogated by either selective caspase 8 or caspase 9 inhibitor and thus implicating the essential role of the mitochondria-driven death signaling cascade. SAHA-dependent strong activation of NF-kB is completely abrogated by TRAIL and this is paralleled with caspase 8-mediated cleavage of RIP (receptor-interacting protein) to form the NF-kB dominant negative cRIP fragment in combination-treated cells. Induction of mild TRAIL sensitivity by the SMAC-mimetic drug SM164 in TRAIL-resistant cells H2373 or Gats greatly sensitizes them to SAHA+TRAIL cytotoxic effects. Most importantly, SAHA+TRAIL combinations with or without SM164 are not toxic to normal cells.
Conclusion: SAHA+TRAIL combination induces profound cytotocidal effect in MPM cells that is dependent on intrinsic death signaling pathway, RIP processing and modulation of NF-kB transcriptional activity. Ongoing investigations are undertaken to further elucidate the molecular basis of this salutary drug combination effects and to develop molecular strategy aiming at promoting SAHA+TRAIL cytotoxicity in TRAIL-resistant MPM cells.
Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3489.</jats:p
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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