1,724,911 research outputs found
Block Card 3436 Kirby Place
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: dwelling | 3436 Kirby Place (Toledo, Ohio) | Ranch Style (Toledo, Ohio) | John L. Gornys Stickney Avenue Addition (Toledo, Ohio) | North Toledo (Toledo, Ohio) | Stickney-Buckeye Area (Toledo, Ohio) | Stickney-Buckeye Area (Toledo, Ohio) | Buckeye Basin (Toledo, Ohio
Block Card 3436 Hughes Boulevard
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: attached garage | Ranch Style | 3436 Hughes Boulevard (Toledo, Ohio) | Dwelling | Dorrland Park Addition (Toledo, Ohio) | University Hills area (Toledo, Ohio
Block Card 3436 Woodley Court
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling | 3436 Woodley Court (Toledo, Ohio) | Ranch houses | Trail Acres (Toledo, Ohio) | Westgate Area (Toledo, Ohio) | West Toledo area (Toledo, Ohio
CSC-3436 switched tamoxifen-induced autophagy to apoptosis through the inhibition of AMPK/mTOR pathway
No full text[[abstract]]Background
Triple-negative breast cancer (TNBC) lacks specific therapeutic target and limits to chemotherapy and is essential to develop novel therapeutic regimens. Increasing studies indicated that tamoxifen, a selective estrogen receptor modulators (SERMs), has anti-tumor therapeutic effect in estrogen receptor α (ERα)-negative tumor. Here, we determined whether autophagy was activated by tamoxifen in TNBC cells. Moreover, CSC-3436 displayed strong and selective growth inhibition on cancer cells. Next, we investigated the anti-proliferation effect of combination of CSC-3436 plus tamoxifen on cell death in TNBC cells.
Results
Our study found that tamoxifen induces autophagy in TNBC cells. Endoplasmic reticulum stress and AMPK/mTOR contributed tamoxifen-induced autophagy. Interestingly, in combination treatment with CSC-3436 enhanced the anti-proliferative effect of tamoxifen. We found that CSC-3436 switched tamoxifen-induced autophagy to apoptosis via cleavage of ATG-5. Moreover, AMPK/mTOR pathway may involve in CSC-3436 switched tamoxifen-induced autophagy to apoptosis. The combination of tamoxifen and CSC-3436 produced stronger tumor growth inhibition compared with CSC-3436 or tamoxifen alone treatments in vivo.
Conclusion
These data indicated that CSC-3436 combined with tamoxifen may be a potential approach for treatment TNBC
[Veto of H. 3436, R-101]
Full text linkThis veto message from Governor Mark Sanford vetoes H. 3436, R-101, a bill to establish the Dorchester County Board of Elections and Registration and provide for its membership and governance, and to abolish the Dorchester County Election Commission and the Dorchester County Board of Voter Registration and devolve its powers and duties in the Board established in this act
[IO Islamic 3436] خمسۀ امير خسرو
No full textKhamsa-i-Amîr Khusrau.
This manuscript is now IO Islamic 1199 in the India Office collections.
[metadata: Hermann Ethé, Catalogue of Persian Manuscripts in the Library of the India Office, 2 vols. (Oxford: India Office, 1903): volume 1, number 3436 here with notations and hyperlinks].
1199
The same.
Contents:
1.Maṭla’-alanwâr, on fol. 1b.
2.Lailâ u Majnûn, on fol. 48b.
3.Shîrîn u Khusrau, on fol. 84b.
4.Â’îna-i-Iskandarî, on fol. 142b.
5.Hasht Bihisht, on fol. 202b.
A few pages a little injured, especially the last one. No date.
No. 3436, olim 7. J. 2, ff. 248, 4 coll., each ll. 19; clear and distinct Nasta’lîḳ; an illuminated frontispiece at the beginning of each mathnawî; size, 113/8 by 65/8 in
Block Card 3436 W. Central Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Cinema 1 & 2 (Toledo, Ohio) | Postmodern Style | 3436 W. Central Avenue (Toledo, Ohio) | motion picture theaters | Westgate Area (Toledo, Ohio) | lost architectur
CSC-3436 Synergizes with Tamoxifen against Triple-negative Breast Cancer Cells
No full text乳癌為國人女性死因第四名，目前乳癌治療依據患者雌激素接受體(Estrogen Receptor, ER)、黄體素接受體(Progesterone Receptor, PR)及人類第二型類上皮生長因子接受體(Human Epidermal Growth Factor Receptor Type-2, HER-2)等腫瘤標記進行個人化醫療。然而三陰性乳癌(Triple-Negative Breast Cancer, TNBC)因無特定受體表現，因此不適用荷爾蒙治療及標靶治療，目前臨床上並無特定治療藥物。Tamoxifen為最廣泛使用於治療雌激素受體陽性乳癌患者之藥物。本研究探討2-Phenylnaphthyridin-4-Ones (2-PN)衍生物CSC-3436是否可增加Tamoxifen對三陰性乳癌細胞的毒殺作用。結果發現CSC-3436顯著性抑制三陰性乳癌MDA-MB-231、BT-20及BT-549細胞株細胞存活率及增生能力，與Tamoxifen協同治療可以增強其抗癌作用，作用機轉主要透過誘導癌細胞凋亡。我們也發現CSC-3436化合物同時具有阻止乳癌細胞轉移、抑制上皮至間質細胞轉換(Epithelial-Mesenchymal Transition, EMT)、降低轉化生長因子β受體(Transforming Growth Factor Beta Receptor-II, TGFβR-II)及下游p-Samd訊息傳遞等作用。實驗證實CSC-3436可透過誘導癌細胞進行細胞凋亡來與Tamoxifen協同治療三陰性乳癌細胞。Breast cancer is the fourth leading cause of death of female in Taiwan, The current treatment of patients with breast cancer target estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor type II (HER-2) receptor type and other tumor markers for personalized medicine. However, triple negative breast cancer (TNBC) is a non-specific receptor expression and is therefore not suitable for use of hormone therapy and targeted therapy, currently there is no specific clinical treatment. Tamoxifen is one of the most widely used chemotherapeutic agents for the treatment of estrogen receptor (ER)-positive breast cancer patients. The main mechanism of tamoxifen has been demonstrated to induce apoptosis and reduce cell proliferation in tumor cells via inhibition of ER signaling. In this study, we used CSC-3436, a derivatives of 2-phenylnaphthyridin-4-ones (2-PN) to address the hypothesis that the CSC-3436 will sensitize TNBC cells to tamoxifen. The results showed that CSC-3436 reduced cell viability and cell proliferation in TNBC, MDA-MB-231, BT-20 and BT-549 cell lines. CSC-3436 enhanced the anticancer effect of tamoxifen through inducing apoptosis in TNBC cells. We also found that CSC-3436 inhibited TNBC cells metastasis, Epithelial-Mesenchymal Transition (EMT), and reduced the transforming growth factor beta receptor-II (TGFβR-II), as well as downstream p-Samd signal transduction and other effects. CSC-3436 synergized with Tamoxifen against TNBC cells through the induction of apoptosis.致謝 I
中文摘要 III
英文摘要 IV
目次 V
圖表目次 VII
縮寫表 IX
第一章 前言 1
第一節 乳癌（Breast Cancer） 1
第二節 三陰性乳癌（Triple-Negative Breast Cancer） 4
第三節 細胞凋亡（Apoptosis） 6
第四節 上皮及間質細胞轉換（Epithelial-Mesenchymal Transition） 8
第五節 乙型轉化生長因子(Transforming growth factor-β, TGF-β） 12
第六節 CSC-3436化合物介紹 15
第七節 研究動機 17
第二章 材料與方法 18
第一節 材料來源 18
第二節 實驗方法 23
第三章 研究結果 38
第一節 CSC-3436對三陰性乳腺癌細胞之存活率測定 38
第二節 CSC-3436與Tamoxifen對三陰性乳腺癌細胞之協同作用 40
第三節 CSC-3436與Tamoxifen協同治療對三陰性乳癌細胞增生之影響 42
第四節 利用西方墨點法觀察細胞凋亡指標PARP蛋白之表現 44
第五節 CSC-3436是否影響黏附因子E-cadherin表達 45
第六節 CSC-3436是否抑制上皮及間質細胞轉換 52
第七節 CSC-3436抑制乙型轉化生長因子受體 58
第四章 討論 62
第五章 結論 64
第六章 參考文獻 6
Spiller, Cora Jane (Morningstar), 1928-2020 - Collector (SC 3436)
Full text linkFinding aid and full-text scan (Click on Additional Files below) for Manuscripts Small Collection 3436. Bible records and photographs from various families, including Gates, Ballenger, Hines, Nicholls, Gossom, Duncan and Spiller, chiefly of Kentucky. Includes a few other items found in the Bibles such as genealogical notes and obituaries
- …
