1,789,127 research outputs found
Integrated Ocean Drilling Program Expedition 342 Preliminary Report. Paleogene Newfoundland Sediment Drifts, 1 June–30 July 2012
No full textIntegrated Ocean Drilling Program Expedition 342 was designed to recover Paleogene sedimentary sequences with unusually high deposition rates across a wide range of water depths (Sites U1403–U1411). The drilling area is positioned to capture sedimentary and geochemical records of ocean chemistry and overturning circulation beneath the flow of the Deep Western Boundary Current in the northwest Atlantic Ocean. In addition, two operational days were dedicated to a sea trial of the Motion Decoupled Hydraulic Delivery System developmental tool (Site U1402). The expedition was primarily targeted at reconstructing the Paleogene carbonate compensation depth (CCD) in the North Atlantic for reference to recently obtained high-fidelity records of the CCD in the equatorial Pacific. The site located in the deepest water (Site U1403) was at a paleodepth of ~4.5 km 50 m.y. ago, whereas the site located in the shallowest water (Site U1408) can be backtracked to a paleodepth of 2.5km at the same time. The combination of sites yields a record of the history of CCD change over a 2km depth range from the ocean abyss to middle range water depths. Notable findings include the discovery of intermittent calcareous sediments in the Cretaceous, Paleocene, and early to middle Eocene at 4.5 km paleodepth, suggesting a deep Atlantic CCD during these times. We find evidence of carbonate deposition events following the Cretaceous/Paleogene (K/Pg) boundary mass extinction, the Paleocene/Eocene Thermal Maximum, and the Eocene–Oligocene transition. These deposition events may reflect the rebalancing of ocean alkalinity after mass extinctions or abrupt global climate change. Intervals during which the CCD appears to have been markedly shallow in the North Atlantic include the Early Eocene Climatic Optimum, the late Eocene, and the middle Oligocene.A second major objective of Expedition 342 was to recover clay-rich sequences with well-preserved microfossils and high rates of accumulation in comparison to the modest rates of accumulation (~0.5–1 cm/k.y. in the Paleogene) typically encountered at pelagic sites. As anticipated, Expedition 342 recovered sequences with sedimentation rates of as much as 10 cm/k.y.—high enough to enable studies of the dynamics of past abrupt climate change, including both transitions into “greenhouse” and “icehouse” climate states, the full magnitudes of hyperthermal events, and rates of change in the CCD. We find that the thickest central parts of the various sediment drifts typically record similar depositional packages to those recovered in the thin “noses” and “tails” of these drifts, but these central parts are often massively expanded with clay, especially near the CCD. Times of rapid accumulation of drift deposits include the early Eocene to late middle Eocene, the late Eocene to early Oligocene, the late Oligocene and early Miocene, the later Miocene to probable late Pliocene, and the Pleistocene. Widespread hiatuses are present near the Paleocene/Eocene boundary into the middle early Eocene and the middle Oligocene. The Eocene/Oligocene boundary is a period of slow sedimentation at most sites but is expanded at Site U1411. A marked change in the geometry of drift formation is observed in the ?late Pliocene, as has been observed in drift deposits elsewhere.<br/
FIGURES 342–343. 342 in Hydraenidae of Madagascar (Insecta: Coleoptera)
No full textFIGURES 342–343. 342. Author collecting specimens of Sicilicula hygropetrica from a small rock pool being filled by a seep, adjacent to waterfall. 343. Ranomafana National Park, Setam Lodge sign with "artificial" hygropetric areas on stones; arrow indicates rock where seven specimens of Sicilicula n. sp. were collected (all females!). Photos. by Johannes Bergsten (342) and author (343).Published as part of Perkins, Philip D., 2017, Hydraenidae of Madagascar (Insecta: Coleoptera), pp. 1-264 in Zootaxa 4342 (1) on page 261, DOI: 10.11646/zootaxa.4342.1.1, http://zenodo.org/record/104106
Palynological Response to Middle Eocene Climate Variability in the North Atlantic Ocean: IODP Expedition 342, Newfoundland Ridge, Offshore Canada
No full text
Inhibition Zbtb7a by mmu-miR-342-3p via directly binding to its 3′UTR.
No full text(A) Schematic representation of a putative binding site of mmu-miR-342-3p in the 3’UTR of Zbtb7a (up) and the dual-Glo Luciferase assay for the interaction between mmu-miR-342-3p-Mimics and Zbtb7a (down). The miRNA ‘seed’ sequences are indicated in bold in black. WT: WT- Zbtb7a or Mut- Zbtb7a construct was co-transfected into 293T cells with either mimic negative control (mimic NC) or mmu-miR-342-3p mimic (miR-342-3p mimic) and luciferase activities were measured after 24 h transfection. (B) The expression of mmu-miR-342-3p in the HSCs from E. multilocularis-infected mice transfected with inhibitor negative control (NC) or mmu-miR-342-3p inhibitor (Inhibitor) by RT-qPCR. (C) The expression of Zbtb7a at mRNA and protein levels in the HSCs from E. multilocularis-infected mice transfected with mmu-miR-342-3p inhibitor (Inhibitor). (D) The expression of zbtb7a in primary HSCs from E. multilocularis-infected mice at 30-, 60-, and 90-day post-infection (dpi). (E) Correlation between the expression of Zbtb7a and mmu-miR-342-3p. (n = 9, Spearman’s correlation analysis; r, correlation coefficient) Data for final statistical analysis were taken from 3 independent experiments. **p p < 0.001.</p
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Participant 342 Community Conversations Interview
No full textIn this interview, Participant 342 describes their experience as a small business owner and president of a community service organization during the COVID-19 pandemic. The participant says they were able to mobilize their community to sew masks and donate to healthcare providers, long-term care facilities, and residents of their township. They also sewed scrubs at the request of a healthcare provider. The participant shares that this common purpose created unity within the community and a sense of accomplishment and service during the pandemic.New Jersey Department of Healt
The effect of down-regulated mmu-miR-342-3p on HSC activation during <i>E</i>. <i>multilocularis</i> infection.
No full text(A) The expression of mmu-miR-342-3p in the HSCs from E. multilocularis-infected mice after transfecting with inhibitor negative control (NC) or mmu-miR-342-3p inhibitor (inhibitor). (B) Effects of downregulated mmu-miR-342-3p on the expression of HSC activation marker (α-Sma and Vimentin) and quiescent marker Gfap in the HSCs from E. multilocularis-infected mice. (C) The mmu-miR-342-3p expression was significantly downregulated in the mouse livers by CS-mmu-miR-342-3p inhibitor nanoparticles (CSNP-Inhibitor) compared with that of CS-inhibitor negative control nanoparticles (CSNP-NC). (D) The Zbtb7a expression both at mRNA and protein levels were significant upregulated in the livers of E. multilocularis-infected mice by injecting with CS-mmu-miR-342-3p inhibitor nanoparticles. (F) Effect of mmu-miR-342-3p on the expression of α-Sma, Col1α1, Vimentin, and TGF-β in the in the livers of E. multilocularis-infected mice by injecting with CS-mmu-miR-342-3p inhibitor nanoparticles. Data for final statistical analysis were taken from 3 independent experiments. ***p < 0.001.</p
miR-342-5p inhibits osteosarcoma cell growth, migration, invasion, and sensitivity to Doxorubicin through targeting Wnt7b
No full textOsteosarcoma (OS) accounts for 9 percent of cancer-related deaths in young people. The PI3K/Akt signaling, a well-known carcinogenic signaling pathway in human cancer, cooperates with other signaling pathways such as Wnt signaling to promote cancer progression. Wnt7b, as a transforming member of the Wnt family, could activate mTORC1 through PI3K-AKT signaling and is upregulated in OS. In the present study, we found that miR-342-5p inhibits Wnt7b expression via direct binding to Wnt7b 3′-UTR. miR-342-5p overexpression remarkably suppressed the viability and invasion while enhanced the apoptosis of OS cells; meanwhile, Wnt7b, β-catenin, c-myc, and cyclin D1 proteins were reduced while E-cadherin protein showed to be increased. Consistent with its expression pattern, Wnt7b exerted oncogenic effects on OS cells. Wnt7b could significantly attenuate the impacts of miR-342-5p. In conclusion, we demonstrated a miR-342-5p/Wnt7b axis that regulates the capacity of OS cells to proliferate and to invade through Wnt/β-catenin signaling. The miR-342-5p/Wnt7b axis might be novel targets for OS targeted therapy, which needs further in vivo and clinical investigations.</p
- …
