1,789,939 research outputs found
Core-section summary from IODP Hole 338-C0022B
No full textCore-section summary from IODP Hole 338-C0022
Core-section summary from IODP Hole 338-C0021B
No full textCore-section summary from IODP Hole 338-C0021
LIPIcs, Volume 338, SEA 2025, Complete Volume
No full textLIPIcs, Volume 338, SEA 2025, Complete Volum
Participant 338 Community Conversations Essay
No full textIn this essay, Participant 338 discusses challenges with financial instability and social isolation during the COVID-19 pandemic. The participant is surprised about how simple and common actions like sneezing or coughing have become taboo. They express that they are afraid of contracting the coronavirus and losing everything they have worked hard for.New Jersey Department of Healt
Bulletin No. 338 - Wyoming Hybrid Corn Performance Trials 1951-1954
No full textBulletin No. 338 - Wyoming Hybrid Corn Performance Trials 1951-195
Mythical and ritual fragment - CTH 338
No full textNotes on mythical and ritual fragment in the CTH 338. Emmanuel Laroche translated this text as "Fragment mythique et rituel," and classified the concordances in the category of Anatolian mythology in mythological texts (Catalogue des textes Hittites, No. 338).Paper (1 sheet
Supplementary Figure 1 from miR-338-3p Suppresses Gastric Cancer Progression through a PTEN-AKT Axis by Targeting P-REX2a
No full textPDF file - 1425K, Figure S1. miR-338-3p is re-expression in BGC823 cells after transfection with pre-miR-338-3p vector.</p
Circ_0003747 promotes thyroid cancer progression by sponging miR-338-3p to upregulate PLCD3 expression
No full textThe circular RNAs (circRNAs) involved in competitive endogenous RNA (ceRNA) mechanism are critical modulators affecting pathogenesis of thyroid carcinoma (TC). The study’s goal was to investigate the effects of circ 0003747 on the biological progression of papillary thyroid cancer (PTC). Normal thyroid cells Nthy-ori3–1 and TC derived cell lines were used in our study. Sanger sequencing and RNase R treatment were utilized for validating the circular structure of circ_0003747. In our work, circ_0003747 was found to be highly expressed in TC cells. Circ_0003747 knockdown reduced TC cell viability, proliferation, migration, and invasion while increasing cell apoptosis. Circ_0003747 targeted and negatively regulated miR-338-3p expression. Besides, miR-338-3p interacted with PLCD3 to repress its expression. Overexpression of miR-338-3p inhibited TC cell progression, and PLCD3 reversed these effects. Furthermore, PLCD3 overexpression reversed the effects of circ_0003747 knockdown on TC cells. Additionally, the knockdown of circ_0003747 remarkably suppressed tumour size and growth, restrained PLCD3 expression and promoted miR-338-3p expression in nude mice. In conclusion, circ_0003747 facilitated the biological progression of TC by modulating the miR-338-3p/PLCD3 axis, and it may be a new target for TC treatment.
Abbreviations: TC: Thyroid carcinoma; PTC: Papillary thyroid carcinoma; CircRNAs: Circular RNAs; MiRNA: MicroRNA; EMT: Epithelial-mesenchymal transition; HCC: Hepatocellular carcinoma; PLCD3: Phospholipase C Delta 3; CeRNA: Competitive endogenous RNA</p
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