1,724,473 research outputs found
Company 3272 - Publications 3
No full textThe Drysdale Dispatch, newsletter of Company 3272, Clarkia, Idaho. Contents, staff, and an article on attitude, appear on this page
Company 3272 - Publications 4
No full textThe Drysdale Dispatch, newsletter of Company 3272, Clarkia, Idaho. Projects page describes the work being done by the camp personnel
Company 3272 - Publications 1
No full textThe Emerald Extra of the Drysdale Dispatch, a newsletter for Company 3272, F-189, Clarkia, Idaho. Front page cartoon refers to the groups arrival in Idaho
Company 3272 - Publications 2
No full textThe Drysdale Dispatch, newsletter of Company 3272, Clarkia, Idaho. This page has an article on a new winter camp and comments from the Captain
P.Mich.inv. 3272: Receipt for Embole from Aphrodito
No full textEdition of P.Mich. inv. 3272, a nearly complete sixth-century receipt for embo/e from Aphrodito
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
IO Islamic 3272. Rauḍat-alṣafa. A Complete Copy of Mîr-khwând's
No full textIO Islamic 3272. Rauḍat-alṣafa. A Complete Copy of Mîr-khwând’s</p
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Structure-based optimization and binding assays for discovery of tau PET radiotracers: Synthesis and in vivo evaluation of [11C]Z-3272
Full text linkHuman tau protein has six isoforms, differing in the number of microtubule-binding repeats. Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are primarily 4-repeat (4R)-tauopathies, and Alzheimer’s disease (AD) and chronic traumatic encephalopathy (CTE) are mixed 3R/4R-tau. Here, a promising lead compound for positron emission tomography (PET) imaging of non-AD tauopathies (Z5873993272; (methyl-1-(5-(7-hydroxynaphthalen-2-yl)pyridin-2-yl)piperidine-4-carboxylate; Z-3272), was identified as a potential 4R-tau binding ligand through computational structure-based optimization from the 2D structure of known 4R-tau ligands, followed by iterative competition binding assays. Homologous binding assays in post-mortem AD, PSP, and CBD brain with [3H]Z-3272 provided Kd (nM) values (n = 3) of AD = 1.2 ± 0.1, PSP = 2.7 ± 0.9, and CBD = 1.7 ± 0.1. [11C]Z-3272 was synthesized by 11C-methylation, by reaction of [11C]CH3I with 1-(5-(7-hydroxynaphthalen-2-yl)pyridin-2-yl)piperidine-4-carboxylic acid with NaHCO3 in DMF at 70 ºC for 3 min. The crude product was purified by semi-preparative HPLC and formulated in saline, with an overall synthesis time of 35 min from end of bombardment. [11C]Z-3272 was isolated with a non-decay corrected radiochemical yield of 4 ± 1% (n = 4), high radiochemical purity (>95%), and high molar activity (149 ± 55.5 GBq/μmol). PET imaging following bolus injection of [11C]Z-3272 in rats showed high initial brain radioactivity (>2.3 standardized uptake values (SUV)) with moderate washout (~0.7 SUV at 60 min), however, ex vivo studies revealed the rapid formation of troublesome brain penetrant radiometabolites. Medicinal chemistry optimization is underway to improve binding affinity, selectivity, and metabolic stability.The presentation of the authors' names and (or) special characters in the title of the pdf file of the accepted manuscript may differ slightly from what is displayed on the item page. The information in the pdf file of the accepted manuscript reflects the original submission by the author
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