1,804,996 research outputs found
Integrated Ocean Drilling Program Expedition 327 Preliminary Report: Juan de Fuca Ridge-Flank Hydrogeology The hydrogeologic architecture of basaltic oceanic crust: compartmentalization, anisotropy, microbiology, and crustal-scale properties on the eastern flank of Juan de Fuca Ridge, eastern Pacific Ocean, 5 July–5 September 2010
No full textIntegrated Ocean Drilling Program (IODP) Expedition 327 and related experiments focus on understanding fluid–rock interactions in young, upper ocean crust on the eastern flank of the Juan de Fuca Ridge, delineating the magnitude and distribution of hydrologic properties; the extent to which crustal compartments are connected or isolated (laterally and with depth); the rates and spatial extent of ridge-flank fluid circulation; and links between ridge-flank circulation, crustal alteration, and geomicrobial processes. Expedition 327 built on the achievements of IODP Expedition 301 and subsequent submersible and remotely operated vehicle (ROV) expeditions. Both drilling expeditions installed subseafloor borehole observatories ("CORKs") in basement holes to allow borehole conditions to recover to a more natural state after the dissipation of disturbances caused by drilling, casing, and other operations; provide a long-term monitoring and sampling presence for determining fluid pressure, temperature, composition, and microbiology; and facilitate the completion of active experiments to resolve crustal hydrogeologic conditions and processes.During Expedition 327, two basement holes were cored and drilled at Site U1362. Hole U1362A was cored and drilled to 528 meters below seafloor (mbsf) (292 meters subbasement [msb]), subjected to geophysical logging and hydrologic testing, and instrumented with a multilevel CORK observatory. Hole U1362B was drilled to 359 mbsf (117 msb), subjected to a 24 h pumping and tracer injection experiment, and instrumented with a single-level CORK observatory. Both CORK observatories include monitoring of pressure and temperature and downhole fluid and microbiology sampling. Wellhead samplers will be added and a long-term cross-hole test will be initiated during a postdrilling ROV expedition scheduled for Summer 2011. In addition, part of an instrument string deployed in Hole U1301B during Expedition 301 was recovered, and a replacement string of thermal sensors was installed. Finally, a program of shallow sediment coring was completed adjacent to Grizzly Bare outcrop, a suspected site of regional hydrothermal recharge. Thermal measurements and analyses of pore fluid and microbiological samples from a series of holes aligned radially from the outcrop edge will elucidate rates of fluid transport and evolution during the initial stages of ridge-flank hydrothermal circulation
Proceedings of the Integrated Ocean Drilling Program Expedition, Volume 327: Superfast Spreading Rate Crust 4. Juan de Fuca Ridge-Flank Hydrogeology, Expedition 327 of the riserless drilling platform from and to Victoria, British Columbia (Canada)Sites U1362, U1301, 1027, and U1363, 5 July–5 September 2010
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
LIPIcs, Volume 327, STACS 2025, Complete Volume
No full textLIPIcs, Volume 327, STACS 2025, Complete Volum
A miR-327–FGF10–FGFR2-mediated autocrine signaling mechanism controls white fat browning
No full textAbstractUnderstanding the molecular mechanisms regulating beige adipocyte formation may lead to the development of new therapies to combat obesity. Here, we report a miRNA-based autocrine regulatory pathway that controls differentiation of preadipocytes into beige adipocytes. We identify miR-327 as one of the most downregulated miRNAs targeting growth factors in the stromal-vascular fraction (SVF) under conditions that promote white adipose tissue (WAT) browning in mice. Gain- and loss-of-function experiments reveal that miR-327 targets FGF10 to prevent beige adipocyte differentiation. Pharmacological and physiological β-adrenergic stimulation upregulates FGF10 levels and promotes preadipocyte differentiation into beige adipocytes. In vivo local delivery of miR-327 to WATs significantly compromises the beige phenotype and thermogenesis. Contrarily, systemic inhibition of miR-327 in mice induces browning and increases whole-body metabolic rate under thermoneutral conditions. Our data provide mechanistic insight into an autocrine regulatory signaling loop that regulates beige adipocyte formation and suggests that the miR-327–FGF10–FGFR2 signaling axis may be a therapeutic targets for treatment of obesity and metabolic diseases.</jats:p
Resolución UNRN N° 327/2009. Designa docente interino.
No full textFil: Universidad Nacional de Río Negro (U). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución UNRN N° 327/2009. Designa docente interino.fals
Mapping the Discipline of the Olympic Games An Author-Cocitation Analysis
Get PDFThe authors conducted an author cocitation analysis on prominent authors writing about the Olympics during the 1990s. Author cocitation is an established bibliometric technique that can be used to measure the relative similarities of topics written about by the cited authors. This enables a visual representation of the “intellectual space” of the discipline, in this case the Olympics, to be created for the period under review. So core and peripheral research areas are identified, along with their major contributors. The representation appears as a two-dimensional cluster-enhanced map. Subject expertise was then applied to the results to place labels on the generated clusters of authors and their topics
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