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Block Card 3268 Monroe Street
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: False front | 3268 Monroe Street (Toledo, Ohio) | commercial buildings | W.P. Anderson Company Addition | Auburndale Area (Toledo, Ohio
[IO Islamic 3268] انوار سهيلى
No full text<ul>
<li><strong>Anwâr-i-Suhailî.</strong></li>
<li><strong>This manuscript is now IO Islamic 760 in the India Office collections.</strong></li>
<li><strong>[metadata:</strong> <a href="https://en.wikipedia.org/wiki/Carl_Hermann_Eth%C3%A9"><strong>Hermann Ethé</strong></a><strong><em>, </em></strong><a href="http://doi.org/10.5281/zenodo.1323681"><strong><em>Catalogue of Persian Manuscripts in the Library of the India Office,</em></strong> </a><a href="http://doi.org/10.5281/zenodo.1323681"><strong>2 vols. (Oxford: India Office, 1903): volume 1,</strong></a> <strong>number 3268 here with notations and hyperlinks].</strong></li>
</ul>
<p>760</p>
<p>The same.</p>
<p>Dated the 7th of Rajab, A.H. 1168 (A.D. 1755, April 19).</p>
<p>No. 3268, olim 9. J. 3, ff. 314, ll. 17; very unequal Shikasta, probably written by different hands; size, 12 in. by 7<sup>5/8</sup> in.</p>
<p> </p>
Taylor Family Houses - Warren County, Kentucky (SC 3268)
Full text linkFinding aid only for Manuscripts Small Collection 3268. Collection of genealogical and historic research on four Taylor family houses located in Warren County, Kentucky. Includes data on original owners and residents, deeds, and photographs
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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Abstract 3268: A novel signaling axis of APE1-redox-sensitive SOX9 activation underlying reflux-condition-associated chemoresistance in esophageal adenocarcinoma
No full textAbstract Chronic gastroesophageal reflux disease (GERD), characterized by the reflux of acidic bile salts (ABS) into the esophagus, stands as the primary risk factor for esophageal adenocarcinoma (EAC). EAC, known for its aggressive nature and limited response to therapy, exhibits a disheartening 5-year survival rate of less than 20%. Overcoming drug resistance remains a pressing challenge in achieving optimal therapeutic outcomes for EAC patients. Previous studies from our team have unveiled that exposure to ABS leads to the overexpression of Apurinic/apyrimidinic endonuclease (APE1), which orchestrates various oncogenic pathways in EAC cells. In this study, we delve into the influence of ABS in driving APE1-redox-mediated activation of the SOX9 pathway, thus contributing to the chemoresistance observed in EAC. To identify the enrichment of the SOX9 pathway and the heightened downstream target genes in EAC, we analyzed RNA sequencing data and public databases. Cell models, patient tissue arrays, pL2-IL1β transgenic mice, and de-identified xenografts derived from EAC patients (PDXs) were employed to investigate the signaling axis of APE1-redox-SOX9 in oxaliplatin resistance of EAC. Our analysis of public databases unveiled a significant enrichment of the SOX9 pathway in EAC patients. RNA sequencing data from EAC cells exposed to ABS, with or without APE1-knockdown, suggested APE1's involvement in the GERD-activated SOX9 signaling pathway. Immunohistochemistry staining of human patient tissue arrays, along with immunofluorescent staining of L2-IL1ß transgenic mice, confirmed the co-overexpression of APE1, SOX9, and ALDH1A1 in EAC. Furthermore, APE1 silencing led to the downregulation of SOX9 and exhibited synergistic effects with oxaliplatin in chemo-resistant EAC cells. Mechanistically, we uncovered that APE1's redox function is crucial for AKT-GSK3ß-mediated SOX9 stability. Treatment with the APE1-redox-specific inhibitor, APX2009, sensitized patient-derived xenograft (PDX) tumors to oxaliplatin by repressing SOX9-regulated chemoresistance genes. This study sheds light on a novel signaling axis involving APE1-redox-AKT-GSK3ß-SOX9 in Barrett’s carcinogenesis. The pharmacological inhibition of APE1-redox function presents itself as a promising therapeutic approach to target the previously intractable SOX9 signals, potentially overcoming chemoresistance in EAC. Citation Format: Heng Lu, Lei Chen, Farah Ballout, Dunfa Peng, Zheng Chen, Jianwen Que, Steven Chen, Oliver Gene McDonald, Alexander Zaika, Wael El-Rifai. A novel signaling axis of APE1-redox-sensitive SOX9 activation underlying reflux-condition-associated chemoresistance in esophageal adenocarcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 3268
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
The globular cluster systems of NGC 3258 and NGC 3268 in the Antlia cluster
Full text linkThe Antlia galaxy cluster is the third nearest galaxy cluster after Virgo and Fornax. We used the wide-field MOSAIC camera of the 4-m CTIO telescope to search in the brightest cluster galaxies for globular cluster systems, which were detected in the two larger ellipticals - NGC 3258 and NGC 3268. These galaxies each contain several thousand clusters; NGC 3258 more than NGC 3268. The color distributions of the globular cluster systems are clearly bimodal. The peak colors agree with those of other ellipticals. The radial number density profiles of the globular cluster systems are indistinguishable for the two galaxies and no difference in the distribution of red and blue clusters - as observed in other elliptical galaxies - can be seen. The light profile of NGC 3268 appears to be similar to that of NGC 1399, the central galaxy of the Fornax cluster. NGC 3258 has a light profile which is steeper at large radii. Both galaxies exhibit color gradients, becoming bluer outwards. In NGC 3268, the color and morphology in the inner 3″ indicate the presence of an inner dusty disk. The globular cluster systems closely trace the galaxy light in the studied radial regime. The elongation of the cluster systems of both galaxies is approximately aligned at large radii with the connecting axis of the two galaxies. We find specific frequencies within a radial range of 4′ of SN - 3.0 ± 2.0 for NGC 3268 and SN = 6.0 ± 2.5 for NGC 3258. As a byproduct resulting from surveying our wide-field frames, we describe a strange absorption feature in the Antlia spiral galaxy NGC 3269, which we argue might be a tiny galactic dust cloud projected onto NGC 3269.Facultad de Ciencias Astronómicas y Geofísica
Adjusted Odds Ratios (aOR): Factors associated with institutional delivery <i>(N = 3268)</i>.
No full textAdjusted Odds Ratios (aOR): Factors associated with institutional delivery (N = 3268).</p
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