1,724,478 research outputs found
Abstract 3266: Oral rinse point of care test to predict head and neck cancer
No full textAbstract
Background: Head and neck squamous cell carcinoma (HNSCC) is the 6th most common cause of cancer mortality throughout the world affecting some 50,000 people in the US and 600,000 worldwide each year. The ability to detect the disease in a potentially malignant phase and earlier stage could have significant impact on overall outcome. Previous studies have demonstrated that a combined salivary CD44, a tumor-initiating marker, and total protein assay was able to aid in the diagnosis of HNSCC. We sought to understand the performance characteristics of these biomarkers in a prospective population using a qualitative, point-of-care assay (POC) which consists of a cassette with a colorimetric read-out based on a pre-determined threshold for both CD44 and total protein. We also performed results from same samples with a quantitative lab-based test.
Methods: Saline oral rinse specimens (~5ml) from 134 patients (84 HNSCC cases; 50 controls) were obtained from biorepositories. Samples were thawed, gently swirled, placed in a standard collection cup. 600ul were removed for lab assay prior to POC test. The tapered end of the POC cassette was submerged in rinse for 20’; levels of CD44 and total protein (TP) were evaluated by two operators. POC test results were compared between operators and with lab test results using Cohen’s kappa coefficient and McNemar’s test, sensitivity(Se), specificity(Sp), NPV and PPV.
Results: 95% HNSCC patients (cases) were mean 60 years of age, 60% male, 97% white and 74% smokers vs. 43 years, 28%, 96% and 0% respectively, for controls. POC was positive with either CD44 or TP above threshold. Weighted kappa yielded 75% and 72% for CD44 and TP respectively between operators. With a prevalence of 9.27: POC: NPV 94%, PPV 10%; variable TP cut-off produced Se71-84% and Sp30%-50%. McNemar and Kappa for both lab CD44 and TP vs POC indicated moderate agreement; independently both POC and lab produced NPV >90%.
Conclusions: Concordance of the POC assay between operators and moderate agreement with a quantitative lab assay provides supportive evidence for clinical application of the POC assay as an aid in the diagnosis for HNSCC. Additional studies are underway to confirm these observations.
Citation Format: Michael J. Donovan, Kris Curtis, Greg Ginn, Elizabeth J. Franzmann. Oral rinse point of care test to predict head and neck cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3266. doi:10.1158/1538-7445.AM2017-3266</jats:p
Santa Fe (ATSF) 3266
No full textA photograph print showing Santa Fe 3266, 2-8-2 (BLW), class 3160, Topeka, KS
Astronomische Nachrichten, nos 3266-3273
No full textR. Astronomische Nachrichten, nos 3266-3273. In: Bulletin astronomique, tome 12, 1895. pp. 183-192
Block Card 3266 Winston Boulevard
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Split-Level Style | 3266 Winston Boulevard (Toledo, Ohio) | Dwelling | Heather Downs Second Addition (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
Vooroordelen van Nederlanders tegenover joden
Full text linkContains fulltext :
3266.pdf (Publisher’s version ) (Open Access
Thomson, Patrick Henry, 1819-1901 (SC 3266)
Full text linkFinding aid only for Manuscripts Small Collection 3266. Farm journal kept by Patrick Henry Thomson of Hurricane Hall, Fayette County, Kentucky. He records daily temperatures and farm operations, and makes occasional mention of his and wife Julia\u27s activities. A loose item dated 10 November 1852 gives him notice of a meeting in regards to the recent fire at the county courthouse
Low velocity impact response and post impact compression behaviour of ES<sup>TM</sup>-fabric/3266 composites
No full textA novel kind of lattice-distributed ESTM-fabrics (ES-L) and random-distributed ESTM-fabrics (ES-R) were developed by using polyethersulfone (PES) and U3160 according to ex-situ toughening technology. ESTM-fabrics reinforced 3266 moderate temperature curing epoxy resin composites (ESTM-fabric/3266) were prepared through RTM process. Impact resistance and residual strength of ESTM-fabric/3266 were studied and the ex-situ toughening mechanism was analyzed by fluorescence microscope and SEM. The untoughened U3160 fabrics reinforced 3266 moderate temperature curing epoxy resin composites were studied to compare performance of composites as well. The result of low velocity impact testing shows that the toughened ESTM-fabric/3266 composites exhibit the higher delamination damage threshold load, the lower projected delaminated areas, the slower damage development, compared to U3160/3266 composites without toughener PES (ES-U).The major failure mode is intralaminar crack (transverse matrix cracking), debonding between fibre and matrix in fiber-bundle regions as well as local ply breakage along with ply-matrix debonding.The ES-L allows an increase of 37% in CAI compared to ES-U. Microstructural observation of damage zone reveals that ES-R composite has a homogeneous distribution of phase inversion in the interlaminar regions while ES-L composite exhibits a hard phase composing of the 3266 epoxy resin continuous matrix and a soft phase composing of the nodular structure of BMI in the 3266 epoxy resin continuous matrix. The excellent impact resistance and damage tolerance of ES-L composite are due to synergistic effects of hard phase and soft phase, which can release the stress concentration,give the extra strain energy dissipated and subsequently terminate crack via crack blunting mechanism
- …
