1,724,509 research outputs found
Block Card 3236 Cambridge Street
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: multi-family | American four and a half square | Dwelling | 3236 CAmbridge Street (Toledo, Ohio) | Cottage Park Addition (Toledo, Ohio) | Toledo Olde Towne (Toledo, Ohio) | North Toledo (Toledo, Ohio
Block Card 3236 Schneider Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: 3236 Schneider Road (Toledo, Ohio) | Dwelling | Heather Estates (Toledo, Ohio) | South Toledo Area (Toledo, Ohio) | American four and a half squar
Block Card 3236 Gracewood Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch Style | Dwelling | 3236 Gracewood Road (Toledo, Ohio) | Elmhurst Park Addition (Toledo, Ohio) | Deveaux Area (Toledo, Ohio) | West Toledo (Toledo, Ohio
Block Card 3236 Astor Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 3236 Astor Avenue (Toledo, Ohio) | Dwelling | Replat of Vanderbilt Terrace (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
Southern Pacific (SP) 3123, 1742, 2445 & 3236
No full textA photograph postcard showing the Southern Pacific (SP) 3123, 4-6-2 (P-12), and 1742, (2-6-0 (M-6), and 2445, 4-6-2 (P-5), and 3236, 2-8-2 (MK-4) on 2nd section of freight train 824 out of Los Angeles, CA, 90 cars, up 1% grade
The binary white dwarf LHS 3236
Get PDFThe white dwarf LHS 3236 (WD1639+153) is shown to be a double-degenerate binary, with each component having a high mass. Astrometry at the U.S. Naval Observatory gives a parallax and distance of 30.86 ± 0.25 pc and a tangential velocity of 98 km s-1, an
Ratliff, Charles, 1854-1940 (SC 3236)
Get PDFFinding aid and scan (Click on Additional Files below) for Manuscripts Small Collection 3236. Letter, 30 July 1889, of Charles Ratliff, Princeton, Kentucky, on his letterhead as a dealer in building material, hardware, saddlery, roofing, etc., advising of the sale of his quarry property and assuring the recipient that the new owners will promptly supply stone
A novel compound ARN-3236 inhibits salt-inducible kinase 2 and sensitizes ovarian cancer cell lines and xenografts to paclitaxel.
No full textPurpose
Salt-inducible kinase 2 (SIK2) is a centrosome kinase required for mitotic spindle formation and a potential target for ovarian cancer therapy. Here, we examine the effects of a novel small-molecule SIK2 inhibitor, ARN-3236, on sensitivity to paclitaxel in ovarian cancer.
Experimental Design
Results
SIK2 is overexpressed in approximately 30% of high-grade serous ovarian cancers. ARN-3236 inhibited the growth of 10 ovarian cancer cell lines at an IC50 of 0.8 to 2.6 mmol/L, where the IC50 of ARN-3236 was inversely correlated with endogenous SIK2 expression (Pearson r = -0.642, P = 0.03). ARN-3236 enhanced sensitivity to paclitaxel in 8 of 10 cell lines, as well as in SKOv3ip (P = 0.028) and OVCAR8 xenografts. In at least three cell lines, a synergistic interaction was observed. ARN-3236 uncoupled the centrosome from the nucleus in interphase, blocked centrosome separation in mitosis, caused prometaphase arrest, and induced apoptotic cell death and tetraploidy. ARN-3236 also inhibited AKT phosphorylation and attenuated survivin expression.
Conclusions
ARN-3236 is the first orally available inhibitor of SIK2 to be evaluated against ovarian cancer in preclinical models and shows promise in inhibiting ovarian cancer growth and enhancing paclitaxel chemosensitivity.</p
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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