1,726,698 research outputs found
Excerpt about the NWA 2968 meteorite
No full textTitle: "Northwest Africa 2968: A Dunite from 4 Vesta
Block Card 2968 Sylvania Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: 20th Century Commercial Style | 2968 Sylvania Avenue (Toledo, Ohio) | commercial buildings | Deveaux Area (Toledo, Ohio
Payne, William Samuel, 1941-2015 (SC 2968)
Full text linkFinding aid only for Manuscripts Small Collection 2968. Letters of William Samuel Payne to Cora Jane Spiller, Bowling Green, Kentucky, mostly with news of his cousin, Louise (Natcher) Murphy, a novelist and the daughter of Kentucky Congressman William H. Natcher
HB 2968 legislative report
No full textThis archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF cover (viewed on July 26, 2016)."House Bill 2968 (2015) directed the Chief Education Officer to convene a work group to produce this report on how State School Fund (SSF) expenditures relate to the educational attainments of students from families in poverty"--Page 4.Includes bibliographical references (page 17).Mode of access: Internet from the Oregon Government Publications Collection.Text in English
A RNA antagonist of hypoxia-inducible factor-1alpha, EZN-2968, inhibits tumor cell growth
No full textUdgivelsesdato: 2008-NovHypoxia-inducible factor-1 (HIF-1) is a transcription factor that plays a critical role in angiogenesis, survival, metastasis, drug resistance, and glucose metabolism. Elevated expression of the alpha-subunit of HIF-1 (HIF-1alpha), which occurs in response to hypoxia or activation of growth factor pathways, is associated with poor prognosis in many types of cancer. Therefore, down-regulation of HIF-1alpha protein by RNA antagonists may control cancer growth. EZN-2968 is a RNA antagonist composed of third-generation oligonucleotide, locked nucleic acid, technology that specifically binds and inhibits the expression of HIF-1alpha mRNA. In vitro, in human prostate (15PC3, PC3, and DU145) and glioblastoma (U373) cells, EZN-2968 induced a potent, selective, and durable antagonism of HIF-1 mRNA and protein expression (IC(50), 1-5 nmol/L) under normoxic and hypoxic conditions associated with inhibition of tumor cell growth. Additionally, down-regulation of HIF-1alpha protein by EZN-2968 led to reduction of its transcriptional targets and of human umbilical vein endothelial cell tube formation. In vivo, administration of EZN-2968 to normal mice led to specific, dose-dependent, and highly potent down-regulation of endogenous HIF-1alpha and vascular endothelial growth factor in the liver. The effect can last for days after administration of single dose of EZN-2968 and is associated with long residence time of locked nucleic acid in certain tissues. In efficacy studies, tumor reduction was found in nude mice implanted with DU145 cells treated with EZN-2968. Ongoing phase I studies of EZN-2968 in patients with advanced malignancies will determine optimal dose and schedule for the phase II program
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Proposed buildings on Block no 2968 Port Alfred for F.H. Schoeder, Esqr.
No full textProposed buildings on Block no 2968 Port Alfred for F.H. Schoeder, Esqr
Main effects and interactions among three risk perceptions in predicting protection motivation (<i>n</i> = 2968).
No full textMain effects and interactions among three risk perceptions in predicting protection motivation (n = 2968).</p
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