1,726,338 research outputs found
Astronomische nachrichten, nos 2763-2769
No full textR. R. Astronomische nachrichten, nos 2763-2769. In: Bulletin astronomique, tome 4, 1887. pp. 81-88
Smith Family (SC 2763)
Get PDFFinding aid only for Manuscripts Small Collection 2763. History and genealogical data on the Smith family of Butler and Ohio counties in Kentucky and related families. Includes data on Thomas and Vicy (Weeks) Smith, the great-grandparents of Wyatt Earp
Block Card 2763 Chestnut Street
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Gabled Ell | dwelling | 2763 Chestnut Street (Toledo, Ohio) | Extension of Elm Street Addition (Toledo, Ohio) | North Toledo (Toledo, Ohio
The radioactive Substances (Irradiated Material) Exemption (Scotland)Order 1962
Get PDFERAF: A6.SI.1962.2763(S.123 )STATUTORY INSTRUMENTS 1962 No. 2763 (S. 123) ATOMIC ENERGY AND RADIOACTIVE SUBSTANCES The Radioactive Substances (Irradiated Material) Exemption (Scotland) Order 196
2763. Richardus de Sancto Germano, Chronica regni Siciliae (1189-1243)
No full text2763. Richardus de Sancto Germano, Chronica regni Siciliae (1189-1243). In: Molinier Auguste. Les Sources de l'histoire de France - Des origines aux guerres d'Italie (1494). III. Les Capétiens, 1180-1328. Paris : A. Picard et fils, 1903. pp. 165-166
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
2763. Richardus de Sancto Germano, Chronica regni Siciliae (1189-1243)
No full text2763. Richardus de Sancto Germano, Chronica regni Siciliae (1189-1243). In: Molinier Auguste. Les Sources de l'histoire de France - Des origines aux guerres d'Italie (1494). III. Les Capétiens, 1180-1328. Paris : A. Picard et fils, 1903. pp. 165-166
The Oral Ferroportin Inhibitor VIT-2763 Improves Erythropoiesis without Interfering with Iron Chelation Therapy in a Mouse Model of β-Thalassemia
No full textIn β-thalassemia, ineffective erythropoiesis leads to anemia and systemic iron overload. The management of iron overload by chelation therapy is a standard of care. However, iron chelation does not improve the ineffective erythropoiesis. We recently showed that the oral ferroportin inhibitor VIT-2763 ameliorates anemia and erythropoiesis in the Hbbth3/+ mouse model of β-thalassemia. In this study, we investigated whether concurrent use of the iron chelator deferasirox (DFX) and the ferroportin inhibitor VIT-2763 causes any pharmacodynamic interactions in the Hbbth3/+ mouse model of β-thalassemia. Mice were treated with VIT-2763 or DFX alone or with the combination of both drugs once daily for three weeks. VIT-2763 alone or in combination with DFX improved anemia and erythropoiesis. VIT-2763 alone decreased serum iron and transferrin saturation (TSAT) but was not able to reduce the liver iron concentration. While DFX alone had no effect on TSAT and erythropoiesis, it significantly reduced the liver iron concentration alone and in the presence of VIT-2763. Our results clearly show that VIT-2763 does not interfere with the iron chelation efficacy of DFX. Furthermore, VIT-2763 retains its beneficial effects on improving ineffective erythropoiesis when combined with DFX in the Hbbth3/+ mouse model. In conclusion, co-administration of the oral ferroportin inhibitor VIT-2763 and the iron chelator DFX is feasible and might offer an opportunity to improve both ineffective erythropoiesis and iron overload in β-thalassemia
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