1,746,618 research outputs found
HB 2667 Task Force report : procuring through small and local business
No full textThis archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF cover (viewed on August 22, 2014)The Task Force was created with the directive of studying public contract awards to minority-owned, woman-owned or emerging small businesses (MWESB) in the state of OregonMode of access: Internet from the Oregon Government Publications Collection.Text in Englis
Astronomische Nachrichten, nos 2667-2670
No full textRadau Rodolphe. Astronomische Nachrichten, nos 2667-2670. In: Bulletin astronomique, tome 2, 1885. pp. 354-356
BAY 58-2667 suppresses cardiomyocyte ROS.
No full text<p>The effects of <b>A</b> BAY 58-2667 and <b>B</b> BAY 41-2272 (both 0.1 µmol/L, n = 8 cardiomyocyte preparations) on cardiomyocyte superoxide generation, added 24 h prior to ET<sub>1</sub> (60 nmol/L, determined on lucigenin-enhanced chemiluminescence). Values are expressed as percentage of paired control myocytes and given as mean±SEM, where n = number of myocyte preparations. The ability of sGC ligands to enhance cardiomyocyte cGMP accumulation in the presence of the sGC-oxidizing agent ODQ (10 µmol/L) is also shown, for <b>C</b> BAY 58-2667 and <b>D</b> BAY 41-2272 (both 0.1 µmol/L, n = 6 cardiomyocyte preparations). ***P<0.001, <sup>δδ</sup>P<0.01, <sup>δ</sup>P<0.05 vs control; <sup>###</sup>P<0.001, <sup>#</sup>P<0.05 vs BAY 58-2667 alone (one-way repeated measures ANOVA with Student-Newman-Keuls <i>post-hoc</i> analysis).</p
IO Islamic 2667. Akbarnâma, History of the Emperor Akbar
No full textIO Islamic 2667. Akbarnâma, History of the Emperor Akbar</p
Block Card 2667 Goddard Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: English Cottage Style | 2667 Goddard Road (Toledo, Ohio) | Dwelling | Old Orchard Area (Toledo, Ohio) | Westgate Area (Toledo, Ohio) | Haughton Place Addition (Toledo, Ohio
The soluble guanylyl cyclase activator bay 58-2667 selectively limits cardiomyocyte hypertrophy
No full textAlthough evidence now suggests cGMP is a negative regulator of cardiac hypertrophy, the direct consequences of the soluble guanylyl cyclase (sGC) activator BAY 58-2667 on cardiac remodeling, independent of changes in hemodynamic load, has not been investigated. In the present study, we tested the hypothesis that the NO(•)-independent sGC activator BAY 58-2667 inhibits cardiomyocyte hypertrophy in vitro. Concomitant impact of BAY 58-2667 on cardiac fibroblast proliferation, and insights into potential mechanisms of action, were also sought. Results were compared to the sGC stimulator BAY 41-2272.Neonatal rat cardiomyocytes were incubated with endothelin-1 (ET(1), 60nmol/L) in the presence and absence of BAY 41-2272 and BAY 58-2667 (0.01-0.3 µmol/L). Hypertrophic responses and its triggers, as well as cGMP signaling, were determined. The impact of both sGC ligands on basal and stimulated cardiac fibroblast proliferation in vitro was also determined.We now demonstrate that BAY 58-2667 (0.01-0.3 µmol/L) elicited concentration-dependent antihypertrophic actions, inhibiting ET(1)-mediated increases in cardiomyocyte 2D area and de novo protein synthesis, as well as suppressing ET(1)-induced cardiomyocyte superoxide generation. This was accompanied by potent increases in cardiomyocyte cGMP accumulation and activity of its downstream signal, vasodilator-stimulated phosphoprotein (VASP), without elevating cardiomyocyte cAMP. In contrast, submicromolar concentrations of BAY 58-2667 had no effect on basal or stimulated cardiac fibroblast proliferation. Indeed, only at concentrations ≥10 µmol/L was inhibition of cardiac fibrosis seen in vitro. The effects of BAY 58-2667 in both cell types were mimicked by BAY 41-2272.Our results demonstrate that BAY 58-2667 elicits protective, cardiomyocyte-selective effects in vitro. These actions are associated with sGC activation and are evident in the absence of confounding hemodynamic factors, at low (submicromolar) concentrations. Thus this distinctive sGC ligand may potentially represent an alternative therapeutic approach for limiting myocardial hypertrophy
Author Self-Citation in the Turkish Otorhinolaryngology Literature
No full textObjective:To evaluate the prevalence and other characteristics of author self-citations in six Turkey-originated general otorhinolaryngology (ORL) journals of Turkish ORL literature.Methods:A total of 970 articles published in six Turkey-originated general ORL journals (ENT Updates, Journal of Ear Nose Throat and Head Neck Surgery, KBB-Forum, Praxis of Otorhinolaryngology, The Turkish Journal of Ear Nose and Throat, and Turkish Archives of Otorhinolaryngology) in 2016-2020 were analyzed for author self-citations. The association between author self-citations and journal types, study types, study topics, country of origin, and compatibility with the topic were also evaluated.Results:There were 265 author self-citations (0.273 per article) which corresponded to 1.36% of all citations. There was no significant difference between the journal types, study topics, and origin of the studies in terms of mean self-citation values per study, whereas case reports had significantly lower self-citations than review and original investigations. There were three citations (1.1%) that were irrelevant to the study topic.Conclusion:To the best of our knowledge, this is the first study that investigated the practice of author self-citation in Turkish ORL literature. Author self-citation rate in the Turkish-originated general ORL journals was found remarkably lower than the medical literature, whereas the self-citations were found compatible with the study topic to a very large extent. Members of the scientific community including authors, readers, and journal editors should be cautious regarding the unethical practices of self-citations
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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