1,733,984 research outputs found
รายงานการประชุมสภาสถาบันบัณฑิตพัฒนบริหารศาสตร์ ครั้งที่ 1-3 พ.ศ. 2509
No full textรายงานการประชุม สภาสถาบันบัณฑิตพัฒนบริหารศาสตร์ ครั้ง 1/2509 วันที่ 27 เมษายน 2509 ณ ทำเนียบรัฐบา
Santa Fe (ATSF) 2509
No full textA photograph postcard showing Santa Fe (ATSF) 2509, 2-8-0, on northbound extra near Lugert, OK, climbing a 1% grade with 24 cars. This is on a relocation around Lake Altus, built by the U.S. Bureau of Reclamation. "This locomotive was originally New York Central, then Orient, until the latter was purchased by ATSF
3D Model of Coprolite (Cod. CL-001-078-3-2509)
No full textCÓDIGO DE LA PIEZA: CL-001-078-3-2509
CATEGORÍA: Fósil
CLASIFICACIÓN: Coprolito
ADQUISICIÓN: Donación
FECHA DE REGISTRO: 22-09-2022ITEM CODE: CL-001-078-3-2509
CATEGORY: Fossil
CLASSIFICATION: Coprolite
ACQUISITION: Donation
REGISTRATION DATE: 22-09-202
Block Card 2509 Goddard Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Garrison Colonial Style | 2509 Goddard Road (Toledo, Ohio) | Dwelling | Barton Place Addition (Toledo, Ohio) | Old Orchard Area (Toledo, Ohio
Block Card 2509 Stickney Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Gable front houses | Folk House Style | 2509 Stickney Avenue (Toledo, Ohio) | Extension of Mulberry Addition (Toledo, Ohio) | North Toledo (Toledo, Ohio
Block Card 2509 Lexington Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: box bay | Folk House Style | Dwelling | Goodale Park Addition (Toledo, Ohio) | Auburndale Area (Toledo, Ohio) | 2509 Lexington Avenue (Toledo, Ohio
Antiviral Properties of the LSD1 Inhibitor SP-2509
No full textLysine-specific demethylase 1 (LSD1) targets cellular proteins, including histone H3, p53, E2F, and Dnmt1, and is involved in the regulation of gene expression, DNA replication, the cell cycle, and the DNA damage response. LSD1 catalyzes demethylation of histone H3K9 associated with herpes simplex virus 1 (HSV-1) immediate early (IE) promoters and is necessary for IE gene expression, viral DNA replication, and reactivation from latency. We previously found that LSD1 associates with HSV-1 replication forks and replicating viral DNA, suggesting that it may play a direct role in viral replication or coupled processes. We investigated the effects of the LSD1 inhibitor SP-2509 on the HSV-1 life cycle. Unlike previously investigated LSD1 inhibitors tranylcypromine (TCP) and OG-L002, which covalently attach to the LSD1 cofactor flavin adenine dinucleotide (FAD) to inhibit demethylase activity, SP-2509 has previously been shown to inhibit LSD1 protein-protein interactions. We found that SP-2509 does not inhibit HSV-1 IE gene expression or transcription factor and RNA polymerase II (Pol II) association with viral DNA prior to the onset of replication. However, SP-2509 does inhibit viral DNA replication, late gene expression, and virus production. We used EdC labeling of nascent viral DNA to image aberrant viral replication compartments that form in the presence of SP-2509. Treatment resulted in the formation of small replication foci that colocalize with replication proteins but are defective for Pol II recruitment. Taken together, these data highlight a potential new role for LSD1 in the regulation of HSV-1 DNA replication and gene expression after the onset of DNA replication. Treatment of HSV-1-infected cells with SP-2509 blocked viral DNA replication, gene expression after the onset of DNA replication, and virus production. These data support a potential new role for LSD1 in the regulation of viral DNA replication and successive steps in the virus life cycle, and further highlight the promising potential to utilize LSD1 inhibition as an antiviral approach
Astrophysical Parameters of the Open Cluster NGC 2509
No full textThis study presents structural and fundamental astrophysical parameters of poorly studied open cluster NGC 2509. We used the third photometric and astrometric data release of the Gaia (Gaia DR3) to perform analyses. By taking into account the Gaia DR3 astrometric data, we calculated the membership probabilities of the stars in the region of NGC 2509. As a result of the membership analysis, 244 stars with membership probabilities P 50% were determined as the physical members of the cluster. The colour excess, distance and age were obtained simultaneously by fitting solar metallicity PARSEC isochrones to G×GBP-GRP colour-magnitude diagram. We considered the most likely cluster member stars during the fitting procedure and calculated the colour excess, distance and age of the NGC 2509 as E(GBP-GRP) = 0.100±0.184 mag, d = 2518±667 pc and t = 1.5±0.1 Gyr, respectively
House Located at 2509 14th Street, Ybor City
No full textA house with a fenced yard located at 2509 14th Street in Ybor City.https://digitalcommons.usf.edu/pizzo_images/1002/thumbnail.jp
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