1,734,734 research outputs found
Chicago & North Western (CNW) 2474
No full textA photograph print showing Chicago & Northwestern (CNW) 2474, 2-8-2 (class J-Alco
[IO Islamic 2474] بكاولى
No full textBakâwalî.
This manuscript is now IO Islamic 829 in the India Office collections.
[metadata: Hermann Ethé, Catalogue of Persian Manuscripts in the Library of the India Office, 2 vols. (Oxford: India Office, 1903): volume 1, number 2474 here with notations and hyperlinks].
829
Another copy of the same.
The beginning of this copy differs from that in the preceding one, but agrees in the main with that of the Berlin copy, viz. زينت ديباچه و سخن بنام سخن آفرين كه قفل گنجینۀ دلهارا بمفتاح الخ.
The author׳s name appears on fol. 6a, last line; the date, A.H. 1134, on fol. 8a, l. 9. The colophon partly torn away.
No. 2474, ff. 141, ll. 11; Nasta’lîḳ, mixed with Shikasta; several pages slightly injured; size, 87/8 in. by 55/8 in
Short Synthesis of <i>tert</i>-Butyl-Hydroxylated 3,5-Di-<i>tert</i>-butyl-4-hydroxybenzaldehyde: Synthesis of <i>tert</i>-Butyl-Hydroxylated S-2474
No full textWe have developed a very short synthesis of tert-butyl-hydroxylated di-tert-butyl-4-hydroxybenzaldehyde in
which the HBr-DMSO system is used as an effective oxidant
(overall yield of 45% for the entire four-step process from
2-tert-butyl-p-cresol). We also accomplished the synthesis of
a major metabolite of the antiarthritic drug candidate
S-2474
Marshall, Kenneth Alvin (SC 2474)
Full text linkFinding aid only for Manuscripts Small Collection 2474. Miscellaneous material collected by Kenneth Alvin Marshall of Bowling Green, Kentucky related to his work as a home builder. Also includes some information about the Bowling Green Chamber of Commerce from 1965; letterhead from the Marshall\u27s Wrestling Attractions operation, and some promotional material about fencing
Global Portrait of Protein Targets of Metabolites of the Neurotoxic Compound BIA 10–2474
No full textClinical
investigation of the fatty acid amide hydrolase (FAAH)
inhibitor BIA 10–2474 resulted in serious adverse neurological
events. Structurally unrelated FAAH inhibitors tested in humans have
not presented safety concerns, suggesting that BIA 10–2474
has off-target activities. A recent activity-based protein profiling
(ABPP) study revealed that BIA 10–2474 and one of its major
metabolites inhibit multiple members of the serine hydrolase class
to which FAAH belongs. Here, we extend these studies by performing
a proteome-wide analysis of covalent targets of BIA 10–2474
metabolites. Using alkynylated probes for click chemistry-ABPP in
human cells, we show that des-methylated metabolites of BIA 10–2474
covalently modify the conserved catalytic cysteine in aldehyde dehydrogenases,
including ALDH2, which has been implicated in protecting the brain
from oxidative stress-related damage. These findings indicate that
BIA 10–2474 and its metabolites have the potential to inhibit
multiple mechanistically distinct enzyme classes involved in nervous
system function
Block Card 2474 Lawton Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Cross gabled | 2474 Lawton Avenue (Toledo, Ohio) | Dwelling | Linden Heights Addition (Toledo, Ohio) | Auburndale Area (Toledo, Ohio) | Folk House Styl
Global Portrait of Protein Targets of Metabolites of the Neurotoxic Compound BIA 10–2474
No full textClinical
investigation of the fatty acid amide hydrolase (FAAH)
inhibitor BIA 10–2474 resulted in serious adverse neurological
events. Structurally unrelated FAAH inhibitors tested in humans have
not presented safety concerns, suggesting that BIA 10–2474
has off-target activities. A recent activity-based protein profiling
(ABPP) study revealed that BIA 10–2474 and one of its major
metabolites inhibit multiple members of the serine hydrolase class
to which FAAH belongs. Here, we extend these studies by performing
a proteome-wide analysis of covalent targets of BIA 10–2474
metabolites. Using alkynylated probes for click chemistry-ABPP in
human cells, we show that des-methylated metabolites of BIA 10–2474
covalently modify the conserved catalytic cysteine in aldehyde dehydrogenases,
including ALDH2, which has been implicated in protecting the brain
from oxidative stress-related damage. These findings indicate that
BIA 10–2474 and its metabolites have the potential to inhibit
multiple mechanistically distinct enzyme classes involved in nervous
system function
Other title: Written Testimony on House Bill 2474; Other title: House Bill 2474; Other title: HB 2474
No full text"March 1, 2018."; Testimony before the Kansas Legislature, Senate Judiciary Committee, presented by Elizabeth Saadi, PhD, State Registrar for Vital Records and Director, Bureau of Epidemiology and Public Health Informatics, Kansas Department of Health and Environment."Neutral, written testimony for House Bill 2474. ... KDHE supports the provisions of this bill which provides through legislation current practice for electronic filing of Kansas marriage events."
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